Results 91 to 100 of about 2,384 (248)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
First In-orbit Experience of TerraSAR-X Flight Dynamics Operations
, 2007 TerraSAR-X is an advanced synthetic aperture radar satellite system for scientific and commercial applications that is realized in a public-private partnership between the German Aerospace Center (DLR) and the Astrium GmbH.
Kiehling, Reinhard +11 more
core
Flight Dynamics Operations of the TanDEM-X Formation
, 2012 Since end of 2010 the German TerraSAR-X and TanDEM-X satellites are routinely operated as the first configurable single-pass Synthetic Aperture Radar interferometer in space. The two 1340 kg satellites fly in a 514 km sun-synchronous orbit.
Aida, Saika +4 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Precise Orbit Determination of GPS Satellites Using Phase Observables [PDF]
Journal of Astronomy and Space Sciences, 1997 The accuracy of user position by GPS is heavily dependent upon the accuracy of satellite position which is usually transmitted to GPS users in radio signals.
Myung-Kook Jee +2 more
doaj
OPERATIONAL ASPECTS OF ORBIT DETERMINATION WITH GPS FOR SMALL SATELLITES WITH A SAR PAYLOAD.
, 2005 Scientific small satellite missions for remote sensing with Synthetic Aperture Radar (SAR) payloads or high accuracy optical sensors, pose very strict requirements on the accuracy of the reconstructed satellite positions, velocities and accelerations ...
Zehetbauer, Tino +2 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
GPS Based Reduced-Dynamic Orbit Determination for Low Earth Orbiters with Ambiguity Fixing
International Journal of Aerospace Engineering, 2015 With the ever-increasing number of satellites in Low Earth Orbit (LEO) for scientific missions, the precise determination of the position and velocity of the satellite is a necessity.
Yang Yang, Xiaokui Yue, Jianping Yuan
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source