Results 91 to 100 of about 6,687 (290)

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

GNSS Satellite Orbit Validation Using Satellite Laser Ranging [PDF]

open access: yes, 2013
With a total of four new regional and global navigation sa tellite systems that have launched first satellites or even started an operational serv ice, the GNSS landscape has experienced major changes in recent years.
Steigenberger, Peter   +2 more
core  

Precise Orbit Determination of GPS Satellites Using Phase Observables [PDF]

open access: yesJournal of Astronomy and Space Sciences, 1997
The accuracy of user position by GPS is heavily dependent upon the accuracy of satellite position which is usually transmitted to GPS users in radio signals.
Myung-Kook Jee   +2 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Precise Orbit Determination for ALOS [PDF]

open access: yes, 2007
The Advanced Land Observing Satellite (ALOS) has been developed to contribute to the fields of mapping, precise regional land coverage observation, disaster monitoring, and resource surveying.
Katagiri, Seiji   +3 more
core   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

GPS Based Reduced-Dynamic Orbit Determination for Low Earth Orbiters with Ambiguity Fixing

open access: yesInternational Journal of Aerospace Engineering, 2015
With the ever-increasing number of satellites in Low Earth Orbit (LEO) for scientific missions, the precise determination of the position and velocity of the satellite is a necessity.
Yang Yang, Xiaokui Yue, Jianping Yuan
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Accuracy Assessment of SGP4 Orbit Information Conversion into Osculating Elements [PDF]

open access: yes, 2013
The SGP4 model is one of the analytical orbit models applied for the orbit prediction using TLE orbit information. For the orbit accuracy improvement, a model conversion was performed to apply a more precise model. Assuming that a TLE data set is the
Aida, Saika, Kirschner, Michael
core  

Home - About - Disclaimer - Privacy