Results 111 to 120 of about 2,642,880 (286)
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Application of variance component estimation to precise orbit determination for ERS-2
, 2001 Variance component estimation (VCE) is applied to precise orbit determination (POD) of the ERS-2 satellite. Twenty 5-day long arcs in the early three months in 1998 were calculated using the SLR and PRARE data.
Zhang, FP +4 more
core
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
Kinematic and reduced-dynamic precise orbit determination of low earth orbiters [PDF]
Advances in Geosciences, 2003 Various methods for kinematic and reduced-dynamic precise orbit determination (POD) of Low Earth Orbiters (LEO) were developed based on zero- and double-differencing of GPS carrier-phase measurements with and without ambiguity resolution.
D. Švehla, M. Rothacher
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Realtime Precise Orbit Determination Technology for LEO Mega-Constellation
天地一体化信息网络Supported by GNSS, it analyzed the advantages and disadvantages of solving LEO satellite orbit on the ground or onboard the satellites.The high-fidelity non-conservative force models were applied to the real-time orbit determination algorithm.To separate
Zhen LI, Chuang SHI
doaj +2 more sources
Orbit Determination via a Deeply- Coupled UKF/GNSS Filter [PDF]
فصلنامه علوم و فناوری فضایی, 2016 This paper is dedicated to determining the orbit of a satellite by using Unscented Kalman Filter (UKF), in which, a GNSS is used as the observation sensor.
MohammadAli Amiri Atashgah +2 more
doaj
Orbit determination of FedSat based on GPS receiver position solutions – first results [PDF]
, 2003 On 14th December 2002, the Australian small satellite FedSat was launched with a Japanese HII-A rocket into an 800 km sun-synchronous orbit with an inclination of 98.6 degrees.
Enderle, Werner +2 more
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source