Results 101 to 110 of about 99,959 (290)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Characterizing receiver clock behaviors onboard Low Earth Orbiters: A case study of GRACE satellites
Geodesy and Geodynamics, 2019 Accurate estimation of clocks, for example for the Gravity Recovery And Climate Experiment (GRACE) twin-satellites, is a critical part of precise orbit determination (POD) that ensures temporal gravity inversion. Characterizing the periodic variations of
Tzu-Pang Tseng, C.K. Shum, Ting-Yi Yang
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Effect of lunar gravity models on Chang'E-2 orbit determination using VLBI tracking data
Geodesy and Geodynamics, 2016 The precise orbit determination of Chang'E-2 is the most important issue for successful mission and scientific applications, while the lunar gravity field model with big uncertainties has large effect on Chang'E-2 orbit determination.
Erhu Wei +3 more
doaj +1 more source
The Geoscience Laser Altimetry/Ranging System (GLARS) [PDF]
The Geoscience Laser Altimetry Ranging System (GLARS) is a highly precise distance measurement system to be used for making extremely accurate geodetic observations from a space platform.
Abshire, J. B. +4 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A Study into the Method of Precise Orbit Determination of a HEO Orbiter by GPS and Accelerometer [PDF]
In the present day, orbit determination by Global Positioning System (GPS) is not unusual. Especially for low-cost small satellites, position determination by an on-board GPS receiver provides a cheap, reliable and precise method.
Hashida, Yoshi +2 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Kinematic and reduced-dynamic precise orbit determination of low earth orbiters [PDF]
Advances in Geosciences, 2003 Various methods for kinematic and reduced-dynamic precise orbit determination (POD) of Low Earth Orbiters (LEO) were developed based on zero- and double-differencing of GPS carrier-phase measurements with and without ambiguity resolution.
D. Švehla, M. Rothacher
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source