Results 101 to 110 of about 6,687 (290)

Precise relative orbit determination of twin GRACE satellites

Geo-spatial Information Science, 2010
When formation flying spacecrafts are used as platform to gain earth oriented observation, precise baselines between these spacecrafts are always essential. Gravity recovery and climate experiment (GRACE) mission is aimed at mapping the global gravity field and its variation.
Qile Zhao, Zhigang Hu, Jing Guo 0005, Min Li, Maorong Ge   +4 more
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Characterizing receiver clock behaviors onboard Low Earth Orbiters: A case study of GRACE satellites

Geodesy and Geodynamics, 2019
Accurate estimation of clocks, for example for the Gravity Recovery And Climate Experiment (GRACE) twin-satellites, is a critical part of precise orbit determination (POD) that ensures temporal gravity inversion. Characterizing the periodic variations of
Tzu-Pang Tseng, C.K. Shum, Ting-Yi Yang
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Precise Orbit Determination of Low Earth Satellites at AIUB using GPS and SLR [PDF]

, 2013
An ever increasing number of low Earth orbiting (LEO) satellites is, or will be, equipped with retro-reflectors for Satellite Laser Ranging (SLR) and on-board receivers to collect observations from Global Navigation Satellite Systems (GNSS) such as ...
Thaller, Daniela, Baumann, Christian, Dach, Rolf, Bock, Heike, Meyer, Ulrich, Jäggi, Adrian, Sosnica, Krzysztof Jakub   +6 more
core  

Geometrical and Kinematical Precise Orbit Determination of GOCE [PDF]

, 2010
The geometrical point-wise Low Earth Orbiters (LEO) positions can be derived by Global Navigation Satellite System (GNSS) analysis techniques. The different precise point positioning techniques based on GNSS observations will be designated as Geometrical
Shabanloui, Akbar
core   +2 more sources

Effect of lunar gravity models on Chang'E-2 orbit determination using VLBI tracking data

Geodesy and Geodynamics, 2016
The precise orbit determination of Chang'E-2 is the most important issue for successful mission and scientific applications, while the lunar gravity field model with big uncertainties has large effect on Chang'E-2 orbit determination.
Erhu Wei, Xuechuan Li, Shuanggen Jin, Jingnan Liu   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source