Results 101 to 110 of about 4,218,282 (383)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Precision medicine and traditional chinese medicine of dialogue

BIO Web of Conferences, 2017
The precision medicine is more precise individualized medicine, based on the patient’s genes or physiological to formulate the specific treatment plan, for the realization of individualized treatment of various diseases to provide valuable information ...
Lou Xin, Bai Ming, Miao Mingsan
doaj   +1 more source

Coronary Physiology: Delivering Precision Medicine?

Reviews in Cardiovascular Medicine, 2022
Coronary physiological assessment is now widely used to assess epicardial coronary lesions in cath lab. Based on clinical evidence, fractional flow reserve (FFR) is the gold standard method to select whether epicardial coronary lesions need ...
Laura Maitre-Ballesteros, Laurent Riou, Stephanie Marliere, Marjorie Canu, Estelle Vautrin, Nicola Piliero, Oliviez Ormezzano, Helene Bouvaist, Alexis Broisat, Catherine Ghezzi, Daniel Fagret, Gérald Vanzetto, Loïc Djaïleb, Gilles Barone-Rochette   +13 more
doaj   +1 more source

Digital Twins’ Advancements and Applications in Healthcare, Towards Precision Medicine

Journal of Personalized Medicine
This review examines the significant influence of Digital Twins (DTs) and their variant, Digital Human Twins (DHTs), on the healthcare field. DTs represent virtual replicas that encapsulate both medical and physiological characteristics—such as tissues ...
Konstantinos Papachristou, P. Katsakiori, P. Papadimitroulas, L. Strigari, G. Kagadis   +4 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Precision Medicine for Frontotemporal Dementia

Frontiers in Psychiatry, 2019
Frontotemporal dementia (FTD) is a common young-onset dementia presenting with heterogeneous and distinct syndromes. It is characterized by progressive deficits in behavior, language, and executive function.
Mu-N Liu, Mu-N Liu, Mu-N Liu, Chi-Ieong Lau, Chi-Ieong Lau, Chi-Ieong Lau, Ching-Po Lin, Ching-Po Lin, Ching-Po Lin   +8 more
doaj   +1 more source

Complexity in cancer stem cells and tumor evolution: towards precision medicine [PDF]

, 2017
In this review, we discuss recent advances on the plasticity of cancer stem cells and highlight their relevance to understand the metastatic process and to guide therapeutic interventions.
La Porta, Caterina A. M., Zapperi, Stefano   +1 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Precision medicine and lymphoma [PDF]

Current Opinion in Hematology, 2018
Purpose of review The treatment of the germinal center lymphomas, diffuse large B cell (DLBCL) and follicular lymphoma, has changed little beyond the introduction of immunochemotherapies. However, there exists a substantial group of patients within both diseases for which improvements in care will involve appropriate tailoring ...
Heward, JA, Kumar, EA, Korfi, K, Okosun, J, Fitzgibbon, J   +4 more
openaire   +4 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source