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Introducing the microbiome into Precision Medicine [PDF]
, 2016 © The Author(s), 2016. This is the author's version of the work and is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Trends in Pharmacological Sciences 38 (2017): 81-91, doi:10.1016/j ...
Gilbert, Jack A., Kuntz, Thomas M.
core +1 more source
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Journal of Translational MedicineAdvancements in data acquisition and computational methods are generating a large amount of heterogeneous biomedical data from diagnostic domains such as clinical imaging, pathology, and next-generation sequencing (NGS), which help characterize ...
V. Brancato +9 more
semanticscholar +1 more source
Precision Medicine on the Effects of Microbiota on Head–Neck Diseases and Biomarkers Diagnosis
Journal of Personalized Medicine, 2023 Precision medicine using highly precise technologies and big data has produced personalised medicine with rapid and reliable diagnoses and targeted therapies. The most recent studies have directed precision medicine into the study of tumours.
A. Inchingolo +15 more
semanticscholar +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The Promise of Explainable AI in Digital Health for Precision Medicine: A Systematic Review
Journal of Personalized MedicineThis review synthesizes the literature on explaining machine-learning models for digital health data in precision medicine. As healthcare increasingly tailors treatments to individual characteristics, the integration of artificial intelligence with ...
Ben Allen
semanticscholar +1 more source
Precision medicine: affording the successes of science
npj Precision Oncology, 2023 Science has made remarkable advances in understanding the molecular basis of disease, generating new and effective rationally-designed treatments at an accelerating rate.
Christine Y. Lu +2 more
semanticscholar +1 more source
SUBIC: A Supervised Bi-Clustering Approach for Precision Medicine
, 2017 Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups.
Levy, Phillip +4 more
core +1 more source
Precision Medicine in Internal Medicine
Annals of Internal Medicine, 2019 Medicine has long sought to match diagnostic and treatment approaches to the particular needs and risks of individual patients. The decreasing cost and increasing ease of genetic sequencing have propelled the rise of precision medicine. Precision medicine aims to use genetic and other information to provide care tailored to the individual patient, with
Ronald J. Wapner +5 more
openaire +3 more sources
Precision Medicine Requires Precision Laboratories [PDF]
The Journal of Molecular Diagnostics, 2017 This commentary highlights the validation study by Lih et al that supports the use of precision medicine for improved clinical trials.
Mangalathu S. Rajeevan +2 more
openaire +3 more sources