Results 71 to 80 of about 1,176,394 (331)

Transdisciplinary Perspectives on Precision Medicine

Health Equity, 2021
Purpose: The Precision Medicine Health Disparities Collaborative fosters collaboration between researchers with diverse backgrounds in precision medicine and health disparities research, to include training at the interface between genomics and health ...
doaj   +1 more source

SAFS: A Deep Feature Selection Approach for Precision Medicine

, 2017
In this paper, we propose a new deep feature selection method based on deep architecture. Our method uses stacked auto-encoders for feature representation in higher-level abstraction.
Levy, Phillip, Li, Xiangrui, Nezhad, Milad Zafar, Yang, Kai, Zhu, Dongxiao   +4 more
core   +1 more source

Precision medicine for suicidality: from universality to subtypes and personalization [PDF]

, 2017
Suicide remains a clear, present and increasing public health problem, despite being a potentially preventable tragedy. Its incidence is particularly high in people with overt or un(der)diagnosed psychiatric disorders.
Ballew, A, Dainton, H L, Gelbart, T, Graham, D L, Jones, T J, Kurian, S M, Le-Niculescu, H, Levey, D F, Niculescu, A B, Niculescu, E M, Niezer, J O, Phalen, P L, Roseberry, K, Salomon, D R, Sandusky, G E, Schork, N J, Shekhar, A, Venugopal, V, Williams, A, Yard, M   +19 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Medical Micro/Nanorobots in Precision Medicine

Advanced Science, 2020
Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine.
Fernando Soto, Jie Wang, Rajib Ahmed, Utkan Demirci   +3 more
doaj   +1 more source

The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine. [PDF]

, 2020
This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data.
Bergan, Raymond, Dickson, Dane, Johnson, Jennifer, Kurzrock, Razelle, Owens, Rebecca, Subbiah, Vivek   +5 more
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Medicina de precisión, un avance necesario

Horizonte Médico, 2018
The scientific evidence is based among other points in clinical trials, whose traditional approach is to encompass to a population of people who are classified by groups or general situations but without greater rigor or individualization; who are given ...
Frank Lizaraso Caparó, Enrique Ruiz Mori   +1 more
doaj   +1 more source

Integrating biomedical research and electronic health records to create knowledge-based biologically meaningful machine-readable embeddings. [PDF]

, 2019
In order to advance precision medicine, detailed clinical features ought to be described in a way that leverages current knowledge. Although data collected from biomedical research is expanding at an almost exponential rate, our ability to transform that
Baranzini, Sergio E, Butte, Atul J, Nelson, Charlotte A   +2 more
core  

Precision Medicine in Internal Medicine

Annals of Internal Medicine, 2019
Medicine has long sought to match diagnostic and treatment approaches to the particular needs and risks of individual patients. The decreasing cost and increasing ease of genetic sequencing have propelled the rise of precision medicine. Precision medicine aims to use genetic and other information to provide care tailored to the individual patient, with
Krzysztof, Kiryluk, David B, Goldstein, John W, Rowe, Ali G, Gharavi, Ronald, Wapner, Wendy K, Chung   +5 more
openaire   +3 more sources