Results 81 to 90 of about 543,221 (233)
Precision medicine and lymphoma [PDF]
Current Opinion in Hematology, 2018 Purpose of review The treatment of the germinal center lymphomas, diffuse large B cell (DLBCL) and follicular lymphoma, has changed little beyond the introduction of immunochemotherapies. However, there exists a substantial group of patients within both diseases for which improvements in care will involve appropriate tailoring ...
Heward, JA +4 more
openaire +4 more sources
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Precision Medicine for Frontotemporal Dementia
Frontiers in Psychiatry, 2019 Frontotemporal dementia (FTD) is a common young-onset dementia presenting with heterogeneous and distinct syndromes. It is characterized by progressive deficits in behavior, language, and executive function.
Mu-N Liu +8 more
doaj +1 more source
Medical Micro/Nanorobots in Precision Medicine
Advanced Science, 2020 Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization of these robotic platforms has led to numerous applications that leverages precision medicine.
Fernando Soto +3 more
doaj +1 more source
Advances in precision medicine: tailoring individualised therapies [PDF]
, 2017 The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer.
Brown, James A.L. +3 more
core +2 more sources
The R.O.A.D. to precision medicine
npj Digital MedicineAbstractWe propose a novel framework that addresses the deficiencies of Randomized clinical trial data subgroup analysis while it transforms ObservAtional Data to be used as if they were randomized, thus paving the road for precision medicine. Our approach counters the effects of unobserved confounding in observational data through a two-step process ...
Dimitris Bertsimas +2 more
openaire +4 more sources
How “precise” is precision medicine in hematology?
Haematologica, 2016 Massive parallel sequencing, the foundation of next generation sequencing (NGS), allows us to sequence the entire exome (the coding sequences of the genome) of leukemia or lymphoma cells, and can be combined with RNA-Seq to evaluate the transcriptome.
GAMBACORTI PASSERINI, CARLO +1 more
openaire +4 more sources
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Transdisciplinary Perspectives on Precision Medicine
Health Equity, 2021 Purpose: The Precision Medicine Health Disparities Collaborative fosters collaboration between researchers with diverse backgrounds in precision medicine and health disparities research, to include training at the interface between genomics and health ...
doaj +1 more source