Results 81 to 90 of about 4,218,282 (383)

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU

American Journal of Respiratory and Critical Care Medicine
Critical care uses syndromic definitions to describe patient groups for clinical practice and research. There is growing recognition that a “precision medicine” approach is required and that integrated biologic and physiologic data identify reproducible ...
Anthony C. Gordon, N. Alipanah-Lechner, L. D. Bos, J. Dianti, Janet Diaz, S. Finfer, Tomoko Fujii, E. Giamarellos‐Bourboulis, E. Goligher, M. N. Gong, E. Karakike, V. Liu, Nuttha Lumlertgul, John C Marshall, David K Menon, Nuala J. Meyer, E. Munroe, S. Myatra, M. Ostermann, Hallie C. Prescott, Adrienne G. Randolph, E. Schenck, Christopher W Seymour, M. Shankar-Hari, M. Singer, M. Smit, Aiko Tanaka, F. Taccone, B. T. Thompson, Lisa K Torres, T. van der Poll, Jean-Louis Vincent, Carolyn S Calfee   +32 more
semanticscholar   +1 more source

Precision Medicine for Endocrinology [PDF]

International Journal of Endocrinology and Metabolism, 2016
In the recent decades, major biotechnological ad- vances have been achieved following the sudden escala- tion of disease-related molecular information, with the potential for greatly advancing patient care. The hu- man genome was depicted in year 2000, followed by the completion of the human genome project in 2003. Sci- entists have ignited a firestorm
openaire   +3 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Enabling precision medicine in neonatology, an integrated repository for preterm birth research [PDF]

, 2018
Preterm birth, or the delivery of an infant prior to 37 weeks of gestation, is a significant cause of infant morbidity and mortality. In the last decade, the advent and continued development of molecular profiling technologies has enabled researchers to ...
Chubiz, Jessica, England, Sarah K., Macones, George   +2 more
core   +5 more sources

Drug screening on digital microfluidics for cancer precision medicine

Nature Communications
Drug screening based on in-vitro primary tumor cell culture has demonstrated potential in personalized cancer diagnosis. However, the limited number of tumor cells, especially from patients with early stage cancer, has hindered the widespread application
Jiao Zhai, Yingying Liu, Weiqing Ji, Xinru Huang, Ping Wang, Yunyi Li, Haoran Li, A. Wong, Xiong Zhou, Ping Chen, Lianhong Wang, Ning Yang, Chi Chen, Haitian Chen, Pui-in Mak, Chuxia Deng, Rui P. Martins, Mengsu Yang, Tsungyi Ho, Shuhong Yi, Hailong Yao, Yanwei Jia   +21 more
semanticscholar   +1 more source

Targeting mitochondrial metabolism for precision medicine in cancer

Cell Death and Differentiation, 2022
During decades, the research field of cancer metabolism was based on the Warburg effect, described almost one century ago. Lately, the key role of mitochondria in cancer development has been demonstrated.
Lourdes Sainero-Alcolado, J. Liaño-Pons, M. V. Ruiz-Pérez, Marie Arsenian-Henriksson   +3 more
semanticscholar   +1 more source

Genomics and precision medicine for clinicians and scientists in hypertension [PDF]

, 2017
No abstract ...
Delles, Christian, Dominiczak, Anna, Padmanabhan, Sandosh   +2 more
core   +1 more source

What Precisely Is Precision Medicine? [PDF]

Trends in Pharmacological Sciences, 2017
In some ways, precision has been a goal for medicine since its first inception. Swallow this herb for a headache, but rub that poultice on a sore foot. Different ailments, everyone realized, require tailored treatments to be effective. As understanding of biological complexity improved, especially with the breakthrough of genetic sequencing, we gained ...
openaire   +3 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source