Results 31 to 40 of about 2,901 (211)

Precision Nutrition for Cardiovascular Disease Prevention

Lifestyle Genomics, 2023
Background: Cardiovascular diseases (CVDs) are the leading cause of death globally, making their prevention a major challenge for modern society.
Louis-Charles Desjardins, Marie-Claude Vohl   +1 more
doaj   +1 more source

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono, Yoshifumi Moriyama, Koji Ohashi, Naoya Otaka, Minako Tatsumi, Toyoaki Murohara, Noriyuki Ouchi, Satoru Oshima   +7 more
wiley   +1 more source

Intramolecular chalcogen bonding activated SuFEx click chemistry for efficient organic-inorganic linking

Nature Communications
SuFEx click chemistry demonstrates remarkable molecular assembly capabilities. However, the effective utilization of alkyl sulfonyl fluoride hubs in SuFEx chemistry, particularly in reactions with alcohols and primary amines, presents considerable ...
Minlong Wang, Jiaman Hou, Hainam Do, Chao Wang, Xiaohe Zhang, Ying Du, Qixin Dong, Lijun Wang, Ke Ni, Fazheng Ren, Jie An   +10 more
doaj   +1 more source

CAR-M Therapy: From Concept to Clinical Translation in Solid Tumors

Cells
While chimeric antigen receptor (CAR)-T-cell therapies have shown significant effectiveness in hematological malignancies, their efficacy in solid tumors remains limited by the hostile tumor microenvironment (TME) and antigen heterogeneity. Recently, CAR-
Chenxi Miao, Zhitao Chen, Juan Chen, Jiazeng Sun, Yanan Sun, Wenbiao Shi, Wentao Xu, Yixuan Li, Xingwang Zhao   +8 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Overview of foodborne hazards associated with inflammation and metabolic health

BMC Global and Public Health
Access to safe and nutritious food is key to ensuring health and well-being and is critical to meeting the United Nations’ Sustainable Development Goals.
Srishti Sinha, Laura S. Hackl, Samantha L. Huey, Elisabetta Lambertini, Stella Nordhagen, Anna M. Bennett, Nidhi Shrestha, Nathaniel L. Cole, Julia L. Finkelstein, Saurabh Mehta   +9 more
doaj   +1 more source

Precision Nutrition for Public Health

Nutrients
Public health—understood as both a science and a practice aimed at preventing disease, prolonging life, and promoting health—has become one of the most critical domains of institutional action, shaped by both nation-states and international organizations [...]
Sabina Lachowicz-Wiśniewska, Agata Kotowska   +1 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science
Oral delivery of bioactive proteins remains a challenging area, as it demands effective gastric protection and intestinal site‐specific release. We design two intestinal site‐specific microgels via Fe3+‐COO− coordination or STMP‐conjugated cross‐linking ...
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
doaj   +1 more source