Results 31 to 40 of about 110,187 (260)

Intramolecular chalcogen bonding activated SuFEx click chemistry for efficient organic-inorganic linking

Nature Communications
SuFEx click chemistry demonstrates remarkable molecular assembly capabilities. However, the effective utilization of alkyl sulfonyl fluoride hubs in SuFEx chemistry, particularly in reactions with alcohols and primary amines, presents considerable ...
Minlong Wang, Jiaman Hou, Hainam Do, Chao Wang, Xiaohe Zhang, Ying Du, Qixin Dong, Lijun Wang, Ke Ni, Fazheng Ren, Jie An   +10 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Precision nutrition in the context of bariatric surgery

Reviews in Endocrine and Metabolic Disorders, 2023
AbstractBariatric surgery (BS) is the most effective long-term treatment for severe obesity. This review summarizes the main nutritional deficiencies before and after BS, as well as current dietary and supplementation recommendations to avoid them.
Maite Aguas-Ayesa, Patricia Yárnoz-Esquíroz, Laura Olazarán, Javier Gómez-Ambrosi, Gema Frühbeck   +4 more
openaire   +3 more sources

Single-cell CyTOF profiling reveals alterations in B, T and macrophage subsets during murine hepatic aging

Frontiers in Immunology
IntroductionPopulation aging is a global demographic shift closely associated with immune dysregulation, which significantly increases the risk of chronic liver diseases.
Zheng Ding, Bing Fang, Jing Peng, Siyu Wang, Siyu Wang, Xiaomin Tian, Guixi Chen, Yuqiu Wei, Yuebin Gao, Yixuan Li, Jiazeng Sun, Jiazeng Sun   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Precision nutrition for cardiometabolic diseases

Nature Medicine
Precision nutrition is a vibrant and rapidly evolving field of scientific research and innovation with the potential to deliver health, societal and economic benefits by improving healthcare delivery and policies. Advances in deep phenotyping technologies, digital tools and artificial intelligence have made possible early proof-of-concept research that
Guasch-Ferré, Marta, Wittenbecher, Clemens, Palmnas, Marie, Ben-Yacov, Orly, Dahm, Christina C., Fall, Tove, Heitmann, Berit L., Licht, Tine Rask, Löf, Marie, Loos, Ruth, Patel, Chirag, Quarta, Carmelo, Redman, Leanne M., Segal, Eran, Segata, Nicola, Snyder, Michael, Sun, Qi, Tobias, Deirdre, Hu, Frank B., Franks, Paul, Landberg, Rikard, Sargent, Jennifer, Merino, Jordi, Blaak, Ellen   +23 more
openaire   +5 more sources

Overview of foodborne hazards associated with inflammation and metabolic health

BMC Global and Public Health
Access to safe and nutritious food is key to ensuring health and well-being and is critical to meeting the United Nations’ Sustainable Development Goals.
Srishti Sinha, Laura S. Hackl, Samantha L. Huey, Elisabetta Lambertini, Stella Nordhagen, Anna M. Bennett, Nidhi Shrestha, Nathaniel L. Cole, Julia L. Finkelstein, Saurabh Mehta   +9 more
doaj   +1 more source

CAR-M Therapy: From Concept to Clinical Translation in Solid Tumors

Cells
While chimeric antigen receptor (CAR)-T-cell therapies have shown significant effectiveness in hematological malignancies, their efficacy in solid tumors remains limited by the hostile tumor microenvironment (TME) and antigen heterogeneity. Recently, CAR-
Chenxi Miao, Zhitao Chen, Juan Chen, Jiazeng Sun, Yanan Sun, Wenbiao Shi, Wentao Xu, Yixuan Li, Xingwang Zhao   +8 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Enhancement of Mechanical Properties of Zein-Based Nanofibers by Incorporation of Millet Gliadin

Foods
In this work, a novel reinforcing filler, millet gliadin (MG), was used for the improvement of the mechanical properties of zein nanofibers. The structural and physicochemical properties of MG were compared with those of zein, and the influence of MG on ...
Shumin Wang, Pengjie Wang, Siyuan Liu, Ran Wang, Yixuan Li, Xiaoyu Wang, Fazheng Ren, Jie Luo, Bing Fang   +8 more
doaj   +1 more source