Results 51 to 60 of about 2,901 (211)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Association of marine PUFAs intakes with cardiovascular disease, all-cause mortality, and cardiovascular mortality in American adult male patients with dyslipidemia: the U.S. National Health and Nutrition Examination Survey, 2001 to 2016

Nutrition Journal, 2023
Background The relationship between marine polyunsaturated fatty acid (PUFA) intake and cardiovascular disease and mortality in dyslipidemic patients is unclear.
Xuanfeng Tang, Xinyi Lv, Ruohua Wang, Xiaoqing Li, Wenyu Xu, Nan Wang, Shuran Ma, He Huang, Yucun Niu, Xiangju Kong   +9 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Regulatory mechanisms of hepatocyte PCSK9 expression: translating mechanistic insights into potential nutraceuticals

Chinese Medicine
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a critical regulator of cholesterol metabolism in hepatocytes with profound implications for cardiovascular health. This review explores the intricate regulatory network that controls hepatic PCSK9
Seon Kyeong Park, Jin-Taek Hwang, Hyo-Kyoung Choi, Jangho Lee   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Effects of Reduced Crude Protein Diets with Graded Methionine Supplementation on Growth Performance, Nitrogen Utilization, and Serum Metabolomic Profiles in Growing–Finishing Pigs

Animals
This study evaluated reduced dietary crude protein (CP) with graded methionine (Met) supplementation in growing and finishing pigs. In each phase, 48 crossbred barrows were assigned to four treatments with four replicate pens per treatment and three pigs
Seong Hoon Shim, Su Hyun An, Minji Kim, Jinyoung Jeong, Hwan Ku Kang   +4 more
doaj   +1 more source

Modelling for Precision Nutrition

Journal of Applied Poultry Research, 1997
Abstract This paper discusses the theories behind (and economic implication of) least-cost and maximum-profit feed formulation models. The importance of properly representing biological phenomena in economic models in precisely determining nutrient levels is discussed in the context of maximizing profits for broiler-producing enterprises.
Gene M. Pesti, Bill R. Miller
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

MiR-7 in neurological disorders: beyond metabolic dysregulation

Frontiers in Neuroscience
Brain health depends on the fine coordination of metabolic and neuronal pathways, and disturbances in this balance are recognized as major drivers of neurodegenerative, neurological, and neuropsychiatric disorders.
Cristina Puigdueta, Virginia Pardo-Marqués, Marta Torrecilla-Parra, Mario Fernández-de Frutos, José L. López-Aceituno, Carmen Zamora, Yaiza López-Manchedo, Rebeca Busto, Cristina M. Ramírez   +8 more
doaj   +1 more source