Results 51 to 60 of about 101,159 (258)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Regulatory mechanisms of hepatocyte PCSK9 expression: translating mechanistic insights into potential nutraceuticals

Chinese Medicine
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a critical regulator of cholesterol metabolism in hepatocytes with profound implications for cardiovascular health. This review explores the intricate regulatory network that controls hepatic PCSK9
Seon Kyeong Park, Jin-Taek Hwang, Hyo-Kyoung Choi, Jangho Lee   +3 more
doaj   +1 more source

Effects of Reduced Crude Protein Diets with Graded Methionine Supplementation on Growth Performance, Nitrogen Utilization, and Serum Metabolomic Profiles in Growing–Finishing Pigs

Animals
This study evaluated reduced dietary crude protein (CP) with graded methionine (Met) supplementation in growing and finishing pigs. In each phase, 48 crossbred barrows were assigned to four treatments with four replicate pens per treatment and three pigs
Seong Hoon Shim, Su Hyun An, Minji Kim, Jinyoung Jeong, Hwan Ku Kang   +4 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics

Lifestyle Genomics
Background: Precision nutrition is based on the integration of individual’s phenotypical and biological characteristics including genetic variants, epigenetic marks, gut microbiota profiles, and metabolite fingerprints as well as medical ...
Omar Ramos-Lopez, Taís Silveira Assmann, Elcy Yaned Astudillo Muñoz, Luis Baquerizo-Sedano, Elisa Barrón-Cabrera, Claudio Adrián Bernal, Josefina Bressan, Amanda Cuevas-Sierra, Alberto Dávalos, Ulises De la Cruz-Mosso, Ana Laura De la Garza, Daniel A. De Luis, Rocío I. Díaz de la Garza, Karina Dos Santos, Roxana Carla Fernández-Condori, Alfredo Fernández-Quintela, Diego F. Garcia Diaz, Karina Gonzalez-Becerra, Eliane Lopes Rosado, María-Carmen López de Las Hazas, Bertha Araceli Marín Alejandre, Alberto Angel Martin, Erika Martinez-Lopez, Diego Martínez-Urbistondo, Fermin I. Milagro, Helen Hermana M. Hermsdorff, Begoña Muguerza, Carolina F. Nicoletti, Ana Maria Obregón Rivas, Isela Parra-Rojas, Maria Puy Portillo, José L. Santos, Thais Steemburgo, Maria Elizabeth Tejero, Anny Cristina Terán, Victor Treviño, Bárbara Vizmanos, J. Alfredo Martinez   +37 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Modelling for Precision Nutrition

Journal of Applied Poultry Research, 1997
Abstract This paper discusses the theories behind (and economic implication of) least-cost and maximum-profit feed formulation models. The importance of properly representing biological phenomena in economic models in precisely determining nutrient levels is discussed in the context of maximizing profits for broiler-producing enterprises.
Gene M. Pesti, Bill R. Miller
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source