Results 61 to 70 of about 2,901 (211)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Applying Artificial Intelligence and machine learning in precision nutrition

Nature Communications
A key feature of the Precision Nutrition and Health approach is the ability to tailor interventions to individual variability using multimodal data from large-scale biobanks and cohorts. Artificial intelligence (AI) and machine learning (ML) models offer
Paraskevi Massara, Jonathan Kirkland, Ioanna Pagani, Samantha L. Huey, Haym Hirsh, Daniel McDonald, Lucas Patel, Julia L. Finkelstein, Marie Gantz, Fei Wang, David Erickson, Martin T. Wells, Olivier Elemento, Rob Knight, Saurabh Mehta   +14 more
doaj   +1 more source

Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics

Lifestyle Genomics
Background: Precision nutrition is based on the integration of individual’s phenotypical and biological characteristics including genetic variants, epigenetic marks, gut microbiota profiles, and metabolite fingerprints as well as medical ...
Omar Ramos-Lopez, Taís Silveira Assmann, Elcy Yaned Astudillo Muñoz, Luis Baquerizo-Sedano, Elisa Barrón-Cabrera, Claudio Adrián Bernal, Josefina Bressan, Amanda Cuevas-Sierra, Alberto Dávalos, Ulises De la Cruz-Mosso, Ana Laura De la Garza, Daniel A. De Luis, Rocío I. Díaz de la Garza, Karina Dos Santos, Roxana Carla Fernández-Condori, Alfredo Fernández-Quintela, Diego F. Garcia Diaz, Karina Gonzalez-Becerra, Eliane Lopes Rosado, María-Carmen López de Las Hazas, Bertha Araceli Marín Alejandre, Alberto Angel Martin, Erika Martinez-Lopez, Diego Martínez-Urbistondo, Fermin I. Milagro, Helen Hermana M. Hermsdorff, Begoña Muguerza, Carolina F. Nicoletti, Ana Maria Obregón Rivas, Isela Parra-Rojas, Maria Puy Portillo, José L. Santos, Thais Steemburgo, Maria Elizabeth Tejero, Anny Cristina Terán, Victor Treviño, Bárbara Vizmanos, J. Alfredo Martinez   +37 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mechanisms of constipation alleviation by Lacticaseibacillus paracasei BGI-N2: insights from genes to phenotypes

BMC Microbiology
The global prevalence of constipation has been increasing in recent years, posing an urgent need for safer and more effective therapeutic strategies. Given the favorable safety profile and beneficial effects on gut health, probiotics have emerged as a ...
Xing Rao, Qiang Luo, Wanting Wei, Benliang Wei, Xinyu Yang, Yanhong Liu, Yangfeng Wen, Zhihui Ma, Zhinan Wu, Haifeng Zhang, Liang Xiao, Yiyi Zhong, Yuanqiang Zou   +12 more
doaj   +1 more source

Alleviation of allergic rhinitis symptoms in an animal model by Lactiplantibacillus plantarum BGI-N6

Frontiers in Immunology
Allergic rhinitis (AR) is a chronic inflammatory disease with rising global prevalence and a substantial public health burden. Current treatments have limited efficacy and tolerability, highlighting the need for new strategies.
Sihang Cai, Sihang Cai, Xiaowei Xu, Xiaofan Sun, Qiang Luo, Weijian Chen, Xihe Wang, Jielei Zhu, Yanhong Liu, Liang Xiao, Haifeng Zhang, Yuanqiang Zou, Yuanqiang Zou, Yiyi Zhong   +13 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source