Results 61 to 70 of about 110,187 (260)

MiR-7 in neurological disorders: beyond metabolic dysregulation

Frontiers in Neuroscience
Brain health depends on the fine coordination of metabolic and neuronal pathways, and disturbances in this balance are recognized as major drivers of neurodegenerative, neurological, and neuropsychiatric disorders.
Cristina Puigdueta, Virginia Pardo-Marqués, Marta Torrecilla-Parra, Mario Fernández-de Frutos, José L. López-Aceituno, Carmen Zamora, Yaiza López-Manchedo, Rebeca Busto, Cristina M. Ramírez   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Alleviation of allergic rhinitis symptoms in an animal model by Lactiplantibacillus plantarum BGI-N6

Frontiers in Immunology
Allergic rhinitis (AR) is a chronic inflammatory disease with rising global prevalence and a substantial public health burden. Current treatments have limited efficacy and tolerability, highlighting the need for new strategies.
Sihang Cai, Sihang Cai, Xiaowei Xu, Xiaofan Sun, Qiang Luo, Weijian Chen, Xihe Wang, Jielei Zhu, Yanhong Liu, Liang Xiao, Haifeng Zhang, Yuanqiang Zou, Yuanqiang Zou, Yiyi Zhong   +13 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Mechanisms of constipation alleviation by Lacticaseibacillus paracasei BGI-N2: insights from genes to phenotypes

BMC Microbiology
The global prevalence of constipation has been increasing in recent years, posing an urgent need for safer and more effective therapeutic strategies. Given the favorable safety profile and beneficial effects on gut health, probiotics have emerged as a ...
Xing Rao, Qiang Luo, Wanting Wei, Benliang Wei, Xinyu Yang, Yanhong Liu, Yangfeng Wen, Zhihui Ma, Zhinan Wu, Haifeng Zhang, Liang Xiao, Yiyi Zhong, Yuanqiang Zou   +12 more
doaj   +1 more source

Guidance and Position of RINN22 regarding Precision Nutrition and Nutriomics

Lifestyle Genomics
Background: Precision nutrition is based on the integration of individual’s phenotypical and biological characteristics including genetic variants, epigenetic marks, gut microbiota profiles, and metabolite fingerprints as well as medical ...
Omar Ramos-Lopez, Taís Silveira Assmann, Elcy Yaned Astudillo Muñoz, Luis Baquerizo-Sedano, Elisa Barrón-Cabrera, Claudio Adrián Bernal, Josefina Bressan, Amanda Cuevas-Sierra, Alberto Dávalos, Ulises De la Cruz-Mosso, Ana Laura De la Garza, Daniel A. De Luis, Rocío I. Díaz de la Garza, Karina Dos Santos, Roxana Carla Fernández-Condori, Alfredo Fernández-Quintela, Diego F. Garcia Diaz, Karina Gonzalez-Becerra, Eliane Lopes Rosado, María-Carmen López de Las Hazas, Bertha Araceli Marín Alejandre, Alberto Angel Martin, Erika Martinez-Lopez, Diego Martínez-Urbistondo, Fermin I. Milagro, Helen Hermana M. Hermsdorff, Begoña Muguerza, Carolina F. Nicoletti, Ana Maria Obregón Rivas, Isela Parra-Rojas, Maria Puy Portillo, José L. Santos, Thais Steemburgo, Maria Elizabeth Tejero, Anny Cristina Terán, Victor Treviño, Bárbara Vizmanos, J. Alfredo Martinez   +37 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source