Results 41 to 50 of about 101,159 (258)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Association of marine PUFAs intakes with cardiovascular disease, all-cause mortality, and cardiovascular mortality in American adult male patients with dyslipidemia: the U.S. National Health and Nutrition Examination Survey, 2001 to 2016

Nutrition Journal, 2023
Background The relationship between marine polyunsaturated fatty acid (PUFA) intake and cardiovascular disease and mortality in dyslipidemic patients is unclear.
Xuanfeng Tang, Xinyi Lv, Ruohua Wang, Xiaoqing Li, Wenyu Xu, Nan Wang, Shuran Ma, He Huang, Yucun Niu, Xiangju Kong   +9 more
doaj   +1 more source

Estimating Amino Acid Requirements in Real-Time for Precision-Fed Pigs: The Challenge of Variability among Individuals

Animals, 2021
This study aimed to measure protein deposition (PD) in pigs fed with daily tailored diets where either dietary lysine (Lys) or threonine (Thr) were provided at independent levels (ignoring an ideal ratio).
Aline Remus, Luciano Hauschild, Marie-Pierre Létourneau-Montminy, Candido Pomar   +3 more
doaj   +1 more source

Dietary Oncopharmacognosy as a Crosswalk between Precision Oncology and Precision Nutrition

Nutrients, 2023
While diet and nutrition are modifiable risk factors for many chronic and infectious diseases, their role in cancer prevention and control remains under investigation. The lack of clarity of some diet–cancer relationships reflects the ongoing debate about the relative contribution of genetic factors, environmental exposures, and replicative errors in ...
Henry J. Thompson, Tymofiy Lutsiv, John N. McGinley, Hisham Hussan, Mary C. Playdon   +4 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Precision nutrition for cardiometabolic diseases

Nature Medicine
Precision nutrition is a vibrant and rapidly evolving field of scientific research and innovation with the potential to deliver health, societal and economic benefits by improving healthcare delivery and policies. Advances in deep phenotyping technologies, digital tools and artificial intelligence have made possible early proof-of-concept research that
Guasch-Ferré, Marta, Wittenbecher, Clemens, Palmnas, Marie, Ben-Yacov, Orly, Dahm, Christina C., Fall, Tove, Heitmann, Berit L., Licht, Tine Rask, Löf, Marie, Loos, Ruth, Patel, Chirag, Quarta, Carmelo, Redman, Leanne M., Segal, Eran, Segata, Nicola, Snyder, Michael, Sun, Qi, Tobias, Deirdre, Hu, Frank B., Franks, Paul, Landberg, Rikard, Sargent, Jennifer, Merino, Jordi, Blaak, Ellen   +23 more
openaire   +5 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Interaction between hyaluronic acid and phospholipid bilayer and its influence on stability and bioavailability of luteolin-loaded liposomes

Food Chemistry: X
The poor solubility of luteolin limits its food applications, and while liposomes offer a potential delivery solution, their phospholipid bilayer membranes are unstable.
Le Cheng, Ming Zhang, Lin Dong, Yifei Wang, Jianguo Dong, Fang Wu, Chenyan Zheng, Yumeng Ma, Zihan Wang, Ran Wang, Yixuan Li, Bing Fang   +11 more
doaj   +1 more source