Results 41 to 50 of about 2,901 (211)

Enhancement of Mechanical Properties of Zein-Based Nanofibers by Incorporation of Millet Gliadin

Foods
In this work, a novel reinforcing filler, millet gliadin (MG), was used for the improvement of the mechanical properties of zein nanofibers. The structural and physicochemical properties of MG were compared with those of zein, and the influence of MG on ...
Shumin Wang, Pengjie Wang, Siyuan Liu, Ran Wang, Yixuan Li, Xiaoyu Wang, Fazheng Ren, Jie Luo, Bing Fang   +8 more
doaj   +1 more source

Precision nutrition for cardiometabolic diseases

Nature Medicine
Precision nutrition is a vibrant and rapidly evolving field of scientific research and innovation with the potential to deliver health, societal and economic benefits by improving healthcare delivery and policies. Advances in deep phenotyping technologies, digital tools and artificial intelligence have made possible early proof-of-concept research that
Guasch-Ferré, Marta, Wittenbecher, Clemens, Palmnas, Marie, Ben-Yacov, Orly, Dahm, Christina C., Fall, Tove, Heitmann, Berit L., Licht, Tine Rask, Löf, Marie, Loos, Ruth, Patel, Chirag, Quarta, Carmelo, Redman, Leanne M., Segal, Eran, Segata, Nicola, Snyder, Michael, Sun, Qi, Tobias, Deirdre, Hu, Frank B., Franks, Paul, Landberg, Rikard, Sargent, Jennifer, Merino, Jordi, Blaak, Ellen   +23 more
openaire   +5 more sources

Dietary Oncopharmacognosy as a Crosswalk between Precision Oncology and Precision Nutrition

Nutrients, 2023
While diet and nutrition are modifiable risk factors for many chronic and infectious diseases, their role in cancer prevention and control remains under investigation. The lack of clarity of some diet–cancer relationships reflects the ongoing debate about the relative contribution of genetic factors, environmental exposures, and replicative errors in ...
Henry J. Thompson, Tymofiy Lutsiv, John N. McGinley, Hisham Hussan, Mary C. Playdon   +4 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Aptamer functionalized nucleic acid nano drug for targeted synergistic therapy for colon cancer

Journal of Nanobiotechnology, 2023
Due to its complicated pathophysiology, propensity for metastasis, and poor prognosis, colon cancer is challenging to treat and must be managed with a combination of therapy.
Liye Zhu, Jieyu Yuhan, Hao Yu, Boyang Zhang, Longjiao Zhu, Xiaoyun He, Kunlun Huang, Wentao Xu   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Interaction between hyaluronic acid and phospholipid bilayer and its influence on stability and bioavailability of luteolin-loaded liposomes

Food Chemistry: X
The poor solubility of luteolin limits its food applications, and while liposomes offer a potential delivery solution, their phospholipid bilayer membranes are unstable.
Le Cheng, Ming Zhang, Lin Dong, Yifei Wang, Jianguo Dong, Fang Wu, Chenyan Zheng, Yumeng Ma, Zihan Wang, Ran Wang, Yixuan Li, Bing Fang   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source