Results 11 to 20 of about 1,227,969 (402)

Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation

Pharmaceutics, 2022
Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Comprehensive testing for proarrhythmic risks of drugs has been applied in
Xiaoli Tang, Zengwu Wang, Shengshou Hu, Bingying Zhou   +3 more
doaj   +2 more sources

Computational Approaches in Preclinical Studies on Drug Discovery and Development

Frontiers in Chemistry, 2020
Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of drug development in the costly late stage, it has been widely recognized that drug ADMET properties should be considered as early as possible to reduce failure ...
Fengxu Wu, Fengxu Wu, Yuquan Zhou, Yuquan Zhou, Langhui Li, Langhui Li, Xianhuan Shen, Xianhuan Shen, Ganying Chen, Ganying Chen, Xiaoqing Wang, Xiaoqing Wang, Xianyang Liang, Xianyang Liang, Mengyuan Tan, Mengyuan Tan, Zunnan Huang, Zunnan Huang, Zunnan Huang   +18 more
doaj   +2 more sources

Application of Genomics in Preclinical Drug Safety Evaluation [PDF]

Basic & Clinical Pharmacology & Toxicology, 2006
Abstract: Understanding the response of biological systems to xenobiotics is fundamental to the evaluation of drug safety. Toxicologists have traditionally gathered pathological, morphological, chemical and biochemical information from in vivo studies of preclinical species in order to assess drug safety and to determine how new drugs can be safely ...
Michael K. McMillian, Peter Lord, Alex Nie   +2 more
openaire   +4 more sources

Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer drug repurposing

Oncology Letters, 2016
The established urinary antibiotic nitroxoline has recently regained considerable attention, due to its potent activities in inhibiting angiogenesis, inducing apoptosis and blocking cancer cell invasion. These features make nitroxoline an excellent candidate for anticancer drug repurposing.
Shoujun Yuan, Kevin Pan, Qian Zhang, Linna Li, Shanshan Wang, Dexuan Yang   +5 more
openaire   +5 more sources

Ex vivomicro-computed tomography analysis of bleomycin-induced lung fibrosis for preclinical drug evaluation [PDF]

European Respiratory Journal, 2013
Research into the pathogenesis underlying the development of idiopathic pulmonary fibrosis is hampered by a repertoire of animal models that fail to recapitulate all the features of the human disease.
Chris J. Scotton, Brian Hayes, Robert Alexander, Arnab Datta, Ellen Forty, Paul F. Mercer, Andy Blanchard, Rachel C. Chambers   +7 more
openalex   +2 more sources

Establishment and characterization of an orthotopic patient-derived Group 3 medulloblastoma model for preclinical drug evaluation. [PDF]

Sci Rep, 2017
Medulloblastomas comprise a heterogeneous group of tumours and can be subdivided into four molecular subgroups (WNT, SHH, Group 3 and Group 4) with distinct prognosis, biological behaviour and implications for targeted therapies.
Sandén E, Dyberg C, Krona C, Gallo-Oller G, Olsen TK, Enríquez Pérez J, Wickström M, Estekizadeh A, Kool M, Visse E, Ekström TJ, Siesjö P, Johnsen JI, Darabi A.   +13 more
europepmc   +2 more sources

Advancing preclinical drug evaluation through automated 3D imaging for high-throughput screening with kidney organoids. [PDF]

Biofabrication
High-throughput drug screening is crucial for advancing healthcare through drug discovery. However, a significant limitation arises from available in vitro models using conventional 2D cell culture, which lack the proper phenotypes and architectures ...
Oishi H, Tabibzadeh N, Morizane R.
europepmc   +2 more sources

Preclinical evaluation of thermoreversible triamcinolone acetonide hydrogels for drug delivery to the inner ear

International Journal of Pharmaceutics, 2014
Intratympanic glucocorticoid therapy aims to reduce the side effects associated with systemic long-time therapy of inner ear diseases or traumata after cochlear implantation. For that purpose, thermoreversible hydrogels being fluid at room temperature but solid at body temperature are known to be appropriate drug delivery systems. In this work, the two
Engleder, Elisabeth, Honeder, Clemens, Klobasa, Julia, Wirth, Michael, Arnoldner, Christoph, Gabor, Franz   +5 more
openaire   +5 more sources

EVALUATION OF MICRODOSING STRATEGIES FOR STUDIES IN PRECLINICAL DRUG DEVELOPMENT: DEMONSTRATION OF LINEAR PHARMACOKINETICS IN DOGS OF A NUCLEOSIDE ANALOG OVER A 50-FOLD DOSE RANGE

Drug Metabolism And Disposition, 2004
Punam Sandhu, John S. Vogel, Mark J. Rose, Esther A. Ubick, Janice Brunner, Michael A. Wallace, Jennifer K. Adelsberger, Maribeth P. Baker, Paul T. Henderson, Paul G. Pearson, Thomas A. Baillie   +10 more
openalex   +3 more sources

Disease modeling and drug screening using human airway organoids: a systematic review [PDF]

Organoid, 2021
Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Do Hyun Kim, Sung Won Kim
doaj   +1 more source