Results 11 to 20 of about 1,040,826 (380)

Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. [PDF]

Clin Cancer Res, 2023
Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA.   +26 more
europepmc   +4 more sources

Preclinical pharmacodynamic evaluation of antibiotic nitroxoline for anticancer drug repurposing

Oncology Letters, 2016
The established urinary antibiotic nitroxoline has recently regained considerable attention, due to its potent activities in inhibiting angiogenesis, inducing apoptosis and blocking cancer cell invasion.
Qi Zhang, Shanshan Wang, Dexuan Yang, Kevin Pan, Linna Li, S. Yuan   +5 more
semanticscholar   +5 more sources

Comparative evaluation of recommendations for preclinical studies of transporter-mediated drug–drug interactions

Регуляторные исследования и экспертиза лекарственных средств, 2023
Scientific relevance. Sound recommendations for preclinical studies of transporter- mediated pharmacokinetic interactions of medicinal products can help increase the likelihood of identifying potentially nephrotoxic and hepatotoxic medicinal products at ...
V. A. Evteev, N. D. Bunyatyan, E. Yu. Demchenkova, A. B. Prokofiev   +3 more
doaj   +2 more sources

Preclinical Data on Efficacy of 10 Drug-Radiation Combinations: Evaluations, Concerns, and Recommendations

Translational Oncology, 2016
Clinical testing of new therapeutic interventions requires comprehensive, high-quality preclinical data. Concerns regarding quality of preclinical data have been raised in recent reports. This report examines the data on the interaction of 10 drugs with radiation and provides recommendations for improving the quality, reproducibility, and utility of ...
Helen B. Stone, Eric J. Bernhard, C. Norman Coleman, James A. Deye, Jacek Capala, James B. Mitchell, J. Martin Brown   +6 more
openalex   +4 more sources

Attenuating the experimental autoimmune encephalomyelitis model improves preclinical evaluation of candidate multiple sclerosis therapeutics [PDF]

Animal Models and Experimental Medicine
Background Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS), exhibiting hallmarks of both inflammation and neurodegeneration and with limited treatment options.
Vernise J. T. Lim, Melanie J. Murphy, W. Stephen Penrose, Coral Warr, M. Cristina Keightley, Jacqueline M. Orian   +5 more
doaj   +2 more sources

Preclinical evaluation of thermoreversible triamcinolone acetonide hydrogels for drug delivery to the inner ear

International Journal of Pharmaceutics, 2014
Intratympanic glucocorticoid therapy aims to reduce the side effects associated with systemic long-time therapy of inner ear diseases or traumata after cochlear implantation. For that purpose, thermoreversible hydrogels being fluid at room temperature but solid at body temperature are known to be appropriate drug delivery systems. In this work, the two
E. Engleder, C. Honeder, Julia Klobasa, M. Wirth, C. Arnoldner, F. Gabor   +5 more
semanticscholar   +5 more sources

EVALUATION OF MICRODOSING STRATEGIES FOR STUDIES IN PRECLINICAL DRUG DEVELOPMENT: DEMONSTRATION OF LINEAR PHARMACOKINETICS IN DOGS OF A NUCLEOSIDE ANALOG OVER A 50-FOLD DOSE RANGE

Drug Metabolism And Disposition, 2004
Punam Sandhu, John S. Vogel, Mark J. Rose, Esther A. Ubick, Janice Brunner, Michael A. Wallace, Jennifer K. Adelsberger, Maribeth P. Baker, Paul T. Henderson, Paul G. Pearson, Thomas A. Baillie   +10 more
openalex   +3 more sources

Chemotherapeutic Drug Delivery Nanoplatform Development: From Physicochemical to Preclinical Evaluation

International Journal of Molecular Sciences
Through this study, the synergistic behavior of small-molecular-weight, amphiphilic surfactant molecules and the triblock copolymer Pluronic 188 was extensively evaluated based on their ability to formulate nanocarriers with novel properties for the delivery of class II and IV (biopharmaceutical classification system) chemotherapeutic compounds.
Orestis Kontogiannis, Dimitriοs Selianitis, Konstantinos Palikaras, Νatassa Pippa, Stergios Pispas, Efstathios Efstathopoulos, Maria Gazouli   +6 more
openalex   +3 more sources

Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles. [PDF]

, 2012
This study presents a new multimodal imaging approach that includes high-frequency ultrasound, fluorescence intensity, confocal, and spectral imaging to improve the preclinical evaluation of new therapeutics in vivo.
Chu, David, Farkas, Daniel L, Hwang, Jae Youn, Kang, Bong Jin, Lubow, David J, Medina-Kauwe, Lali K, Park, Jinhyoung, Shung, K Kirk   +7 more
core   +12 more sources

P2X7 Receptor Agonist 2′(3′)-O-(4-Benzoylbenzoyl)ATP Differently Modulates Cell Viability and Corticostriatal Synaptic Transmission in Experimental Models of Huntington’s Disease

Frontiers in Pharmacology, 2021
Huntington’s disease (HD) is a life-threatening neurodegenerative disorder. Altered levels and functions of the purinergic ionotropic P2X7 receptors (P2X7Rs) have been found in animal and cellular models of HD, suggesting their possible role in the ...
Alberto Martire, Rita Pepponi, Francesco Liguori, Cinzia Volonté, Cinzia Volonté, Patrizia Popoli   +5 more
doaj   +1 more source