Results 281 to 290 of about 192,321 (310)

Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Nature Reviews Drug Discovery, 2019
Richard Weaver, B Kevin Park, Ursula Klingmüller   +2 more
exaly  

[Preclinical evaluation of anticancer drugs: a model remaining a model!].

Bulletin du cancer, 1998
Two criteria are firstly used in the selection of new anticancer agents:--originality of the mechanism of action and significant experimental antitumor activity in an in vivo animal model. Murine tumors grafted in syngenic mice and human tumor xenografts implanted in nude mice are old models which continue to be widely used.
openaire   +1 more source

Mitigating risk in academic preclinical drug discovery

Nature Reviews Drug Discovery, 2015
Michael A Walters, James Inglese, Jayme L Dahlin   +2 more
exaly  

Human malignant melanoma: preclinical and clinical drug evaluation.

Behring Institute Mitteilungen, 1984
A panel of 17 melanoma xenograft lines was exposed to various DNA reactive agents. Growth delay values were calculated from tumor volume responses of xenograft bearing mice and correlated with donor patient's response as determined by standard clinical criteria.
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Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets

Nature Reviews Drug Discovery, 2016
Patricio O'Donnell, Malcolm Robert Macleod, Dario Doller   +2 more
exaly  

[The problem of preclinical evaluation of psychotropic drugs].

Acta neurologica, 1970
M, Tansella, G, Dello Russo
openaire   +1 more source

[Place of in vitro models in preclinical evaluation of anticancer drugs].

Bulletin du cancer, 1996
In vitro models have been intensively developed for several years for selecting new anticancer agents. The National Cancer Institute has even chosen as a primary screen of new molecules a panel of 60 human tumor cell lines. However, it may seem hazardous to rely too much on in vitro models for the discovery and selection of new anticancer drugs: (1 ...
openaire   +1 more source

Insights from Preclinical Choice Models on Treating Drug Addiction

Trends in Pharmacological Sciences, 2017
S Stevens Negus, Matthew Banks
exaly  

Evaluation of Drug Candidates for Preclinical Development

2009
openaire   +1 more source

Biological basis of sex differences in drug abuse: preclinical and clinical studies

Psychopharmacology, 2002
Wendy Lynch, Megan E Roth, Carroll Marilyn E   +2 more
exaly