Results 281 to 290 of about 8,733,364 (311)

Outcome of Combining Epigenetic Drugs With Other Treatments in the Clinic

Medical Epigenetics, 2016
Paromita Raha
exaly  

[The problem of preclinical evaluation of psychotropic drugs].

Acta neurologica, 1970
M, Tansella, G, Dello Russo
openaire   +1 more source

[Preclinical evaluation of anticancer drugs: a model remaining a model!].

Bulletin du cancer, 1998
Two criteria are firstly used in the selection of new anticancer agents:--originality of the mechanism of action and significant experimental antitumor activity in an in vivo animal model. Murine tumors grafted in syngenic mice and human tumor xenografts implanted in nude mice are old models which continue to be widely used.
openaire   +1 more source

Human malignant melanoma: preclinical and clinical drug evaluation.

Behring Institute Mitteilungen, 1984
A panel of 17 melanoma xenograft lines was exposed to various DNA reactive agents. Growth delay values were calculated from tumor volume responses of xenograft bearing mice and correlated with donor patient's response as determined by standard clinical criteria.
openaire   +1 more source

Angiogenesis Inhibitors: Current Strategies and Future Prospects

Ca-A Cancer Journal for Clinicians, 2010
Kristina M Cook, William Douglas Figg, Jr.   +1 more
exaly  

Evaluation of Drug Candidates for Preclinical Development

2009
openaire   +1 more source

[Place of in vitro models in preclinical evaluation of anticancer drugs].

Bulletin du cancer, 1996
In vitro models have been intensively developed for several years for selecting new anticancer agents. The National Cancer Institute has even chosen as a primary screen of new molecules a panel of 60 human tumor cell lines. However, it may seem hazardous to rely too much on in vitro models for the discovery and selection of new anticancer drugs: (1 ...
openaire   +1 more source

Mitigating Risk in Academic Preclinical Drug Discovery

Nature Reviews Drug Discovery, 2015
Michael A Walters, James Inglese, Jayme L Dahlin   +2 more
exaly  

Preventing Occupational Exposures to Antineoplastic Drugs in Health Care Settings

Ca-A Cancer Journal for Clinicians, 2006
Melissa McDiarmid, Thomas H Connor
exaly  

Preclinical evaluation on anticancer drug: Endocrine therapy drug

Annual Meeting of the Japanese Society of Toxicology, 2007
openaire   +1 more source