Results 21 to 30 of about 303,204 (352)

1st INCF Workshop on Genetic Animal Models for Brain Diseases [PDF]

, 2011
The INCF Secretariat organized a workshop to focus on the “role of neuroinformatics in the processes of building, evaluating, and using genetic animal models for brain diseases” in Stockholm, December 13–14, 2009.
Holm Graessner, Olaf Riess
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Computational Approaches in Preclinical Studies on Drug Discovery and Development

Frontiers in Chemistry, 2020
Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of drug development in the costly late stage, it has been widely recognized that drug ADMET properties should be considered as early as possible to reduce failure ...
Fengxu Wu, Fengxu Wu, Yuquan Zhou, Yuquan Zhou, Langhui Li, Langhui Li, Xianhuan Shen, Xianhuan Shen, Ganying Chen, Ganying Chen, Xiaoqing Wang, Xiaoqing Wang, Xianyang Liang, Xianyang Liang, Mengyuan Tan, Mengyuan Tan, Zunnan Huang, Zunnan Huang, Zunnan Huang   +18 more
doaj   +1 more source

Evaluation of melanin-targeted radiotherapy in combination with radiosensitizing drugs for the treatment of melanoma [PDF]

, 2014
The incidence of malignant melanoma is rising faster than that of any other cancer in the United States. An [131I]-labeled benzamide - [131I]MIP-1145 - selectively targets melanin, reduces melanoma tumor burden and increases survival in preclinical ...
Babich, John, Boyd, Marie, Hutchison, Sharon, Mairs, Robert, Rae, Colin, Tesson, Mathias   +5 more
core   +1 more source

Study on Research and Development Status and Application of 90Y Microspheres

Journal of Isotopes, 2022
With 90Y microspheres, radioactive microspheres are perfused to tumor feeding arteries through minimally invasive intervention, and then diffused and retained in small vessels of tumor terminals along with blood flow, so as to high selectively kill tumor
GAO Jie;LIU Xiaoming;ZHOU Wenhua;WANG Hongliang;ZHAO Xiaosheng;GE Qiang;LI Jianguo
doaj  

In vitro bactericidal activities of two novel dihydropyridine derivatives against Mycobacterium tuberculosis

Journal of Infection in Developing Countries, 2017
Introduction: Introducing new and effective antitubercular agents is important in tuberculosis control programs. In this study, the in vitro antitubercular activity of two novel 1,4-dihydropyridine derivatives (F-27, Cl-33) were screened against a total
Mehdi Zandhaghighi, Farzin Hadizadeh, Saman Soleimanpour, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Kiarash Ghazvini   +6 more
doaj   +1 more source

Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis

Microorganisms, 2022
Combination therapy has, to some extent, been successful in limiting the emergence of drug-resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting on different targets and metabolic pathways.
Hasmik Margaryan, Dimitrios D. Evangelopoulos, Leticia Muraro Wildner, Timothy D. McHugh   +3 more
doaj   +1 more source

Synergistic drug combinations from electronic health records and gene expression. [PDF]

, 2016
ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William, Daugherty, Aaron C, Desai, Manisha, Farrington, Carl, Gomez, Scarlett L, Hastie, Trevor, Kenkare, Pragati, Kurian, Allison W, Lim, Michael, Low, Yen S, Mathur, Maya, Radin, Andrew A, Schroeder, Elizabeth A, Seto, Tina, Shah, Nigam H, Sirota, Marina, Sledge, George W, Thompson, Caroline A, Weber, Susan, Yu, Peter P   +19 more
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Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876—A Less Toxic and More Potent Analogue of Bedaquiline

Molecules, 2020
Bedaquiline is a novel drug approved in 2012 by the FDA for treatment of drug-resistant tuberculosis (TB). Although it shows high efficacy towards drug-resistant forms of TB, its use has been limited by the potential for significant side effects.
Peter J. Choi, Daniel Conole, Hamish S. Sutherland, Adrian Blaser, Amy S.T. Tong, Christopher B. Cooper, Anna M. Upton, Brian D. Palmer, William A. Denny   +8 more
doaj   +1 more source

How to target apoptosis signaling pathways for the treatment of pediatric cancers [PDF]

, 2013
Apoptosis represents one of the most important forms of cell death in higher organisms and is typically dysregulated in human cancers, including pediatric tumors.
Fulda, Simone
core   +2 more sources

Novel strategy for rapid functional in vivo validation of oncogenic drivers in haematological malignancies [PDF]

, 2019
In cancer research, it remains challenging to functionally validate putative novel oncogenic drivers and to establish relevant preclinical models for evaluation of novel therapeutic strategies.
Berx, Geert, D'Hont, Jinke, Demoen, Lisa, Goossens, Steven, Haenebalcke, Lieven, Haigh, Jody J., Hochepied, Tino, Lammens, Tim, Lemeire, Kelly, Lintermans, Béatrice, Matthijssens, Filip, Pedro Pinto De Almeida, André, Pieters, Tim, Reunes, Lindy, T'Sas, Sara, Van Vlierberghe, Pieter, Vanrockeghem, Frédérique   +16 more
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