Results 21 to 30 of about 1,227,969 (402)
Food and Agricultural Immunology, 2021 Emerging evidence indicates that blood–retinal barrier (BRB) damage is the main cause of diabetic retinopathy (DR), and the downregulation of tight proteins (TJs) located between endothelial cells and the activation of NLRP3 inflammasome-mediated ...
Jing Wei +8 more
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Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy
Scientific ReportsTrophoblast cell surface antigen 2 (TROP2), a transmembrane glycoprotein highly expressed in a variety of epithelial cancers, has been considered as a primary therapeutic target for the development of antibody–drug conjugates (ADCs).
Ting-Yu Chang +14 more
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Two preclinical tests to evaluate anticancer activity and to help validate drug candidates for clinical trials. [PDF]
, 2015 Current approaches to assessing preclinical anticancer activity do not reliably predict drug efficacy in cancer patients. Most of the compounds that show remarkable anticancer effects in preclinical models actually fail when tested in clinical trials. We
López Lázaro, Miguel
core +6 more sources
P046: Preclinical evaluation of novel repurposed drug combinations in Hodgkin lymphoma
HemaSphere, 2022 Mia Lohmann +10 more
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Cancer Medicine, 2023 Background Anti‐angiogenic therapy with bevacizumab (BEV), an anti‐VEGF antibody, plays a critical role in the treatment of ovarian cancer. However, despite an encouraging initial response, most tumors become resistant to BEV over time, and a new ...
Tianyue Zhai +6 more
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Frontiers in Pharmacology, 2022 Many medicinal plants species from European -such as Artemisia absinthium, Equisetum arvense, Lamium album, Malva sylvestris, Morus nigra, Passiflora incarnata, Frangula purshiana, and Salix alba- as well as Latin American traditions -such as Libidibia ...
Andre Luis Dias Araujo Mazzari +13 more
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Chinese Medicine, 2021 Background Lei-gong-gen formula granule (LFG) is a folk prescription derived from Zhuang nationality, the largest ethnic minority among 56 nationalities in China.
Qiaofeng Li +12 more
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Animal models of chemotherapy-induced cognitive decline in preclinical drug development
Psychopharmacology, 2021 Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog are the common terms for mental dysfunction in a cancer patient/survivor under the influence of chemotherapeutics.
Jeena John +4 more
semanticscholar +1 more source
IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation
Biomolecules & Biomedicine, 2022 Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, and 3D culture systems are gaining traction in this area, particularly in prostate cancer (PCa) research.
Yipeng Xu +8 more
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Drug-Eluting Stents in Preclinical Studies [PDF]
Circulation: Cardiovascular Interventions, 2008 Coronary drug-eluting stents are commonplace in clinical practice with acceptable safety and efficacy. Preclinical evaluation of novel drug-eluting stent technologies has great importance for understanding safety and possibly efficacy of these technologies, and well-defined preclinical testing methods clearly benefit multiple communities within the ...
Keith A. Robinson +11 more
openaire +3 more sources