Results 301 to 310 of about 303,204 (352)
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Technological Advances in Preclinical Drug Evaluation: The Role of -Omics Methods
Current Medicinal Chemistry, 2020Preclinical drug development is an essential step in the drug development process where the evaluation of new chemical entities occurs. In particular, preclinical drug development phases include deep analysis of drug candidates’ interactions with biomolecules/targets, their safety, toxicity, pharmacokinetics, metabolism by use of assays in vitro and ...
Kraljević Pavelić, Sandra +4 more
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NCI Specialized Procedures in Preclinical Drug Evaluations
2004Agents now come to the U.S. National Cancer Institute (NCI) from many sources for preclinical evaluation and/or potential development (1). In most cases, experimental agents have limited antiproliferative data against a broad spectrum of human cancers, and these agents usually are then tested in the NCI’ s in vitro anticancer drug screen. Data from the
Melinda G. Hollingshead +4 more
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EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms
Radiotherapy and Oncology, 2007Preclinical and clinical results indicate that the EGFR can mediate radioresistance in different solid human tumours. Combination of radiotherapy and EGFR inhibitors can improve local tumour control compared to irradiation alone and has been introduced into clinical radiotherapy practice.
Michael, Baumann +6 more
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Preclinical Models for Evaluating Topoisomerase I-Targeted Drugs
2005Type I and II DNA topoisomerases are the targets for numerous clinically efficacious antitumor agents. Over the last decade, considerable effort has been expended in developing camptothecin (CPT) derivatives that selectively target DNA topoisomerase I (TOP-I) (1).
Aarti S. Juvekar +3 more
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Preclinical Drug Evaluation with Human Melanoma Xenografts
1988In 1974 there was an increasing awareness at the National Cancer Institute of the U.S.A. that important drugs might have been missed by the conventional murine tumor screening system then employed. Differences in biochemistry and cell biology of murine vs. human tumors were increasingly well understood.
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The Scientific Basis of Drug-Drug Interactions: Mechanism and Preclinical Evaluation
Drug Information Journal, 1998Pharmacokinetic drug-drug interactions (PDDI), in which the pharmacokinetic clearance of one drug is altered by a coadministered drug, can be divided mechanistically into two general categories: 1. Inhibitory PDDI—the inhibition of the metabolic clearance of one drug by a coadministered drug, and 2.
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Preclinical Evaluation of Cudetaxestat for Potential Drug-Drug Interactions
B36. SPECTRUM OF FIBROTIC INTERSTITIAL LUNG DISEASES, 2022W. Yu +3 more
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ChemInform Abstract: Drug Safety Evaluation at the Preclinical Stage
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs
Pharmacology & Therapeutics, 1993Forty years after the first clinical report on the effectiveness of chlorpromazine in psychiatric patients, neuroleptic drugs are still the most widely used drugs in the treatment of schizophrenia. Indeed, there are no other drugs which have proven to be as effective in the treatment of this severe psychiatric disorder.
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Preclinical evaluation of drug effects on testicular functions
Pharmacology & Therapeutics, 1979F, Neumann, B, Schenck
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