Results 91 to 100 of about 6,422,598 (270)

Preclinical Imaging: an Essential Ally in Modern Biosciences [PDF]

open access: yesMolecular Diagnosis & Therapy, 2013
Translational research is changing the practice of modern medicine and the way in which health problems are approached and solved. The use of small-animal models in basic and preclinical sciences is a major keystone for these kinds of research and development strategies, representing a bridge between discoveries at the molecular level and clinical ...
Sara Ferreira   +11 more
openaire   +5 more sources

Normal aging and Alzheimer's disease : hippocampal and episodic memory differences [PDF]

open access: yes, 2016
Alzheimer’s Disease (AD) and normal aging (NA) are characterized by structural brain changes as well as cognitive changes that appear over the lifespan.
Marnell, Ashley Michele
core   +1 more source

Optical Imaging Modalities: Principles and Applications in Preclinical Research and Clinical Settings

open access: yesJournal of Nuclear Medicine, 2020
With the ability to noninvasively image and monitor molecular processes within tumors, molecular imaging represents a fundamental tool for cancer scientists. In the current review, we describe emergent optical technologies for molecular imaging.
Giacomo Pirovano   +3 more
semanticscholar   +1 more source

Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study

open access: yesDiagnostics, 2023
Hyperoxic BOLD-MRI targeting tumor hypoxia may provide imaging biomarkers that represent breast cancer molecular subtypes without the use of injected contrast agents.
Silvester J. Bartsch   +6 more
doaj   +1 more source

Preclinical Stage Alzheimer's Disease Detection Using Magnetic Resonance Image Scans [PDF]

open access: yesarXiv, 2020
Alzheimer's disease is one of the diseases that mostly affects older people without being a part of aging. The most common symptoms include problems with communicating and abstract thinking, as well as disorientation. It is important to detect Alzheimer's disease in early stages so that cognitive functioning would be improved by medication and training.
arxiv  

Accomplishments and challenges in stem cell imaging in vivo. [PDF]

open access: yes, 2019
Stem cell therapies have demonstrated promising preclinical results, but very few applications have reached the clinic owing to safety and efficacy concerns.
Bose, Rajendran JC, Mattrey, Robert F
core  

Using the A/T/N framework to examine driving in preclinical Alzheimer’s disease [PDF]

open access: yes, 2018
The A/T/N classification system is the foundation of the 2018 NIA-AA Research Framework and is intended to guide the Alzheimer disease (AD) research agenda for the next 5–10 years.
Ances, Beau M   +9 more
core   +3 more sources

Spectral Imaging in Preclinical Research and Clinical Pathology [PDF]

open access: yes, 2013
Spectral imaging methods are attracting increased interest from researchers and practitioners in basic science, preclinical and clinical arenas. A combination of better labeling reagents and better optics creates opportunities to detect and measure multiple parameters at the molecular and cellular level.
Levenson, Richard   +2 more
openaire   +5 more sources

Acidic ascites inhibits ovarian cancer cell proliferation and correlates with the metabolomic, lipidomic and inflammatory phenotype of human patients

open access: yesJournal of Translational Medicine, 2022
Background The poor prognosis of ovarian cancer patients is strongly related to peritoneal metastasis with the production of malignant ascites. However, it remains largely unclear how ascites in the peritoneal cavity influences tumor metabolism and ...
Qianlu Yang   +11 more
doaj   +1 more source

Small animal whole body imaging with metamaterial-inspired RF coil [PDF]

open access: yes, 2017
Preclinical magnetic resonance imaging often requires the entire body of an animal to be imaged with sufficient quality. This is usually performed by combining regions scanned with small coils with high sensitivity or long scans using large coils with low sensitivity. Here, a metamaterial-inspired design employing of a parallel array of wires operating
arxiv   +1 more source

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