Preclinical evaluation of FAP-2286 for fibroblast activation protein targeted radionuclide imaging and therapy [PDF]
European Journal of Nuclear Medicine and Molecular Imaging, 2022 Fibroblast activation protein (FAP) is a membrane-bound protease that has limited expression in normal adult tissues but is highly expressed in the tumor microenvironment of many solid cancers.
Dirk Zboralski +20 more
openalex +2 more sources
Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging. [PDF]
Front Oncol, 2017 Tumors are often characterized by hypoxia, vascular abnormalities, low extracellular pH, increased interstitial fluid pressure, altered choline-phospholipid metabolism, and aerobic glycolysis (Warburg effect).
Ramamonjisoa N, Ackerstaff E.
europepmc +2 more sources
Preclinical imaging methods for assessing the safety and efficacy of regenerative medicine therapies. [PDF]
NPJ Regen Med, 2017 Regenerative medicine therapies hold enormous potential for a variety of currently incurable conditions with high unmet clinical need. Most progress in this field to date has been achieved with cell-based regenerative medicine therapies, with over a ...
Scarfe L +39 more
europepmc +2 more sources
Comparison of illumination geometry for lifetime-based measurements in whole-body preclinical imaging. [PDF]
J Biophotonics, 2018 Macroscopic fluorescence lifetime imaging (MFLI) has been proved to be an accurate tool to quantify Förster resonance energy transfer (FRET) lifetime‐based assessment of receptor‐ligand engagement in vitro and in vivo.
Sinsuebphon N +4 more
europepmc +2 more sources
Preclinical Imaging of Prostate Cancer. [PDF]
Semin Nucl Med, 2023 Prostate cancer remains a major cause of mortality and morbidity, affecting millions of men, with a large percentage expected to develop the disease as they reach advanced ages. Treatment and management advances have been dramatic over the past 50 years or so, and one aspect of these improvements is reflected in the multiple advances in diagnostic ...
Olkowski C +4 more
europepmc +3 more sources
Lymphoma: current status of clinical and preclinical imaging with radiolabeled antibodies. [PDF]
Eur J Nucl Med Mol Imaging, 2017 England CG, Rui L, Cai W.
europepmc +2 more sources
Laser-Ablated Gold Nanoparticles as Tunable Contrast Agents for Preclinical Imaging. [PDF]
Nanomaterials (Basel)Finogenova Y +9 more
europepmc +3 more sources
DNA nanomaterials for preclinical imaging and drug delivery. [PDF]
J Control Release, 2016 Jiang D, England CG, Cai W.
europepmc +2 more sources
Clinical and Preclinical Imaging of Hepatosplenic Schistosomiasis. [PDF]
Trends in Parasitology, 2019 Schistosomiasis, a neglected tropical disease, is a major cause of chronic morbidity and disability, and premature death. The hepatosplenic form of schistosomiasis is characterized by hepatosplenomegaly, liver fibrosis, portal hypertension, and esophageal varices, whose rupture may cause bleeding and death.
Brice Masi +3 more
semanticscholar +4 more sources
Multimodality imaging in vivo for preclinical assessment of tumor-targeted doxorubicin nanoparticles. [PDF]
, 2012 This study presents a new multimodal imaging approach that includes high-frequency ultrasound, fluorescence intensity, confocal, and spectral imaging to improve the preclinical evaluation of new therapeutics in vivo.
Chu, David +7 more
core +10 more sources