Results 31 to 40 of about 6,433,487 (363)
Molecules, 2023 In an effort to further understand the challenges facing in vivo imaging probe development for the N-methyl-D-aspartate (NMDA) receptor ion channel, we have evaluated the effect of glutamate on the Alzheimer’s disease (AD) brain.
Nehal M. Shah +6 more
doaj +1 more source
Development of [124/125I]IAZA as a New Proteinopathy Imaging Agent for Alzheimer’s Disease
Molecules, 2023 Radioiodinated imaging agents for Aβ amyloid plaque imaging in Alzheimer’s disease (AD) patients have not been actively pursued. Our previous studies employed the “diaza” derivatives [11C]TAZA and [18F]flotaza in order to develop successful positron ...
Thrisha T. Reddy +5 more
doaj +1 more source
In vivo molecular imaging in preclinical research
Laboratory Animal Research, 2022 AbstractIn vivo molecular imaging is a research field in which molecular biology and advanced imaging techniques are combined for imaging molecular-level biochemical and physiological changes that occur in a living body. For biomolecular imaging, the knowledge of molecular biology, cell biology, biochemistry, and physiology must be applied.
Su Jin Kim, Ho-Young Lee
openaire +3 more sources
Molecules, 2021 We report [18F]nifene binding to α4β2* nicotinic acetylcholinergic receptors (nAChRs) in Parkinson’s disease (PD). The study used transgenic Hualpha-Syn(A53T) PD mouse model of α-synucleinopathy for PET/CT studies in vivo and autoradiography in vitro ...
Anthony-David T. Campoy +5 more
doaj +1 more source
Molecules, 2023 Nicotinic acetylcholine receptors (nAChRs) are involved in various central nervous system functions and have also been implicated in several neurodegenerative disorders.
Karanveer Singh +5 more
doaj +1 more source
Why Preclinical Imaging and What Will Happen in the Future?
Frontiers in Biomedical Technologies, 2021 No ...
Razieh Solgi, Ehsan Sharif-Paghaleh
doaj +1 more source
Confocal 3D reflectance imaging through multimode fibers without wavefront shaping [PDF]
, 2021 Imaging through optical multimode fibers (MMFs) has the potential to enable hair-thin endoscopes that reduce the invasiveness of imaging deep inside tissues and organs. Current approaches predominantly require active wavefront shaping and fluorescent labeling, which limits their use to preclinical applications and frustrates imaging speed.
arxiv +1 more source
A Fast 0.5T Prepolarizer Module for Preclinical Magnetic Resonance Imaging [PDF]
IEEE Transactions on Magnetics, vol. 58, no. 2, pp. 1-8, Feb.
2022, Art no. 5100208, 2021 We present a magnet and high power electronics for Prepolarized Magnetic Resonance Imaging (PMRI) in a home-made, special-purpose preclinical system designed for simultaneous visualization of hard and soft biological tissues. PMRI boosts the signal-to-noise ratio (SNR) by means of a long and strong magnetic pulse which must be rapidly switched off ...
arxiv +1 more source
Synthesis, Preclinical Evaluation, and a Pilot Clinical PET Imaging Study of 68Ga-Labeled FAPI Dimer
Journal of Nuclear Medicine, 2021 Visual Abstract Cancer-associated fibroblasts (CAFs) are crucial components of the tumor microenvironment. Fibroblast activation protein (FAP) is overexpressed in CAFs. FAP-targeted molecular imaging agents, including the FAP inhibitors (FAPIs) 04 and 46,
Liang Zhao +10 more
semanticscholar +1 more source
Molecules, 2023 Aggregation of Tau protein into paired helical filaments causing neurofibrillary tangles (NFT) is a neuropathological feature in Alzheimer’s disease (AD).
Roz R. Limpengco +3 more
doaj +1 more source