Results 31 to 40 of about 6,725,081 (364)

Synthesis and Evaluation of Compound Targeting α7 and β2 Subunits in Nicotinic Acetylcholinergic Receptor

Molecules, 2023
Nicotinic acetylcholine receptors (nAChRs) are involved in various central nervous system functions and have also been implicated in several neurodegenerative disorders.
Karanveer Singh, Allyson Ngo, Oshini V. Keerthisinghe, Krystal K. Patel, Christopher Liang, Jogeshwar Mukherjee   +5 more
doaj   +1 more source

Phosphorylcholine-conjugated gold-molecular clusters improve signal for Lymph Node NIR-II fluorescence imaging in preclinical cancer models

Nature Communications, 2022
Sentinel lymph node imaging and biopsy is important to clinical assessment of cancer metastasis, and novel non-radioactive lymphographic tracers have been actively pursued over the years.
Ani Baghdasaryan, Feifei Wang, Fuqiang Ren, Zhuoran Ma, Jiachen Li, Xueting Zhou, Lilit Grigoryan, Chun Xu, Hongjie Dai   +8 more
semanticscholar   +1 more source

[¹⁸F]Nifene PET/CT Imaging in Mice: Improved Methods and Preliminary Studies of α4β2* Nicotinic Acetylcholinergic Receptors in Transgenic A53T Mouse Model of α-Synucleinopathy and Post-Mortem Human Parkinson’s Disease

Molecules, 2021
We report [18F]nifene binding to α4β2* nicotinic acetylcholinergic receptors (nAChRs) in Parkinson’s disease (PD). The study used transgenic Hualpha-Syn(A53T) PD mouse model of α-synucleinopathy for PET/CT studies in vivo and autoradiography in vitro ...
Anthony-David T. Campoy, Christopher Liang, Reisha M. Ladwa, Krystal K. Patel, Ishani H. Patel, Jogeshwar Mukherjee   +5 more
doaj   +1 more source

Quantification of white matter cellularity and damage in preclinical and early symptomatic Alzheimer\u27s disease [PDF]

, 2019
Interest in understanding the roles of white matter (WM) inflammation and damage in the pathophysiology of Alzheimer disease (AD) has been growing significantly in recent years.
Ances, Beau M, Benzinger, Tammie L.S., Blazey, Tyler, Cairns, Nigel J, Chen, Charlie, Cruchaga, Carlos, Fagan, Anne M, Gordon, Brian A, Liu, Jingxia, Morris, John C, Shimony, Joshua S, Su, Yi, Sutphen, Courtney L, Wang, Qing, Wang, Yong   +14 more
core   +2 more sources

Stem Cell Imaging: Tools to Improve Cell Delivery and Viability. [PDF]

, 2016
Stem cell therapy (SCT) has shown very promising preclinical results in a variety of regenerative medicine applications. Nevertheless, the complete utility of this technology remains unrealized. Imaging is a potent tool used in multiple stages of SCT and
Jokerst, Jesse V, Wang, Junxin
core   +3 more sources

Striatal and prefrontal D2R and SERT distributions contrastingly correlate with default-mode connectivity

NeuroImage, 2021
Although brain research has taken important strides in recent decades, the interaction and coupling of its different physiological levels is still not elucidated.
Tudor M. Ionescu, Mario Amend, Rakibul Hafiz, Bharat B. Biswal, Andreas Maurer, Bernd J. Pichler, Hans F. Wehrl, Kristina Herfert   +7 more
doaj   +1 more source

Why Preclinical Imaging and What Will Happen in the Future?

Frontiers in Biomedical Technologies, 2021
No ...
Razieh Solgi, Ehsan Sharif-Paghaleh
doaj   +1 more source

Iterative CT reconstruction using shearlet-based regularization [PDF]

, 2012
In computerized tomography, it is important to reduce the image noise without increasing the acquisition dose. Extensive research has been done into total variation minimization for image denoising and sparse-view reconstruction. However, TV minimization
Goossens, Bart, Pizurica, Aleksandra, Staelens, Steven, Van Holen, Roel, Vandeghinste, Bert, Vandenberghe, Stefaan, Vanhove, Christian   +6 more
core   +1 more source

Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]

, 2020
Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy, Bridoux, Jessica, Broisat, Alexis, Caveliers, Vicky, Cleeren, Frederik, Debie, Pieterjan, Descamps, Benedicte, Devoogdt, Nick, Hernot, Sophie, Neyt, Sara, Vanhove, Christian, Xavier, Catarina   +11 more
core   +2 more sources

4th Internatinal TPCF Preclinical Imaging Symposium

Frontiers in Biomedical Technologies, 2021
Due to the huge costs and time spent for development of new drugs (around almost $ 1 billion (USD) and 12 Years), investing on the preclinical phase of drug development could be regarded as a great investment for de-risking the clinical phases ...
4th Internatinal TPCF Preclinical Imaging
doaj