Results 81 to 90 of about 6,433,487 (363)

Impact of molecular imaging in preclinical cancer research [PDF]

BMC Proceedings, 2013
Development and progression of any cancer disease are the result of various alterations at the cellular and molecular level. This comprises changes in expression of genes, display of surface molecules, composition of extracellular matrix, and homing of circulating cells to the tumor site.
Holger Kalthoff, Carola Heneweer
openaire   +3 more sources

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

[¹²⁵I]IPC-Lecanemab: Synthesis and Evaluation of Aβ-Plaque-Binding Antibody and Comparison with Small-Molecule [¹⁸F]Flotaza and [¹²⁵I]IBETA in Postmortem Human Alzheimer’s Disease

Neurology International
Therapeutic antibodies for reducing Aβ plaque load in Alzheimer’s disease (AD) is currently making rapid progress. The diagnostic imaging of Aβ plaque load in AD has been underway and is now used in clinical studies.
Christopher Liang, Cayz G. Paclibar, Noresa L. Gonzaga, Stephanie A. Sison, Harman S. Bath, Agnes P. Biju, Jogeshwar Mukherjee   +6 more
doaj   +1 more source

Striatal and prefrontal D2R and SERT distributions contrastingly correlate with default-mode connectivity

NeuroImage, 2021
Although brain research has taken important strides in recent decades, the interaction and coupling of its different physiological levels is still not elucidated.
Tudor M. Ionescu, Mario Amend, Rakibul Hafiz, Bharat B. Biswal, Andreas Maurer, Bernd J. Pichler, Hans F. Wehrl, Kristina Herfert   +7 more
doaj  

Hyperoxic BOLD-MRI-Based Characterization of Breast Cancer Molecular Subtypes Is Independent of the Supplied Amount of Oxygen: A Preclinical Study

Diagnostics, 2023
Hyperoxic BOLD-MRI targeting tumor hypoxia may provide imaging biomarkers that represent breast cancer molecular subtypes without the use of injected contrast agents.
Silvester J. Bartsch, Viktoria Ehret, Joachim Friske, Vanessa Fröhlich, Daniela Laimer-Gruber, Thomas H. Helbich, Katja Pinker   +6 more
doaj   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Acidic ascites inhibits ovarian cancer cell proliferation and correlates with the metabolomic, lipidomic and inflammatory phenotype of human patients

Journal of Translational Medicine, 2022
Background The poor prognosis of ovarian cancer patients is strongly related to peritoneal metastasis with the production of malignant ascites. However, it remains largely unclear how ascites in the peritoneal cavity influences tumor metabolism and ...
Qianlu Yang, Gyuntae Bae, Giorgi Nadiradze, Arianna Castagna, Georgy Berezhnoy, Laimdota Zizmare, Aditi Kulkarni, Yogesh Singh, Frank J. Weinreich, Stefan Kommoss, Marc A. Reymond, Christoph Trautwein   +11 more
doaj   +1 more source

Preclinical Imaging: an Essential Ally in Modern Biosciences [PDF]

Molecular Diagnosis & Therapy, 2013
Translational research is changing the practice of modern medicine and the way in which health problems are approached and solved. The use of small-animal models in basic and preclinical sciences is a major keystone for these kinds of research and development strategies, representing a bridge between discoveries at the molecular level and clinical ...
Sara Ferreira, Pedro Costa, Luís F. Metello, Domokos Máthé, Domingos Vieira, Lídia Cunha, Lídia Cunha, Ildiko Horvath, Dániel S. Veres, Joana Lemos, Teresa Summavielle, Krisztián Szigeti   +11 more
openaire   +5 more sources

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β

Molecules, 2023
A technique to image α-synuclein (αSYN) fibrils in vivo is an unmet scientific and clinical need that would represent a transformative tool in the understanding, diagnosis, and treatment of various neurodegenerative diseases. Several classes of compounds
Adriana Di Nanni, Ran Sing Saw, Gregory D. Bowden, Natasha S. R. Bidesi, Kaare Bjerregaard-Andersen, Špela Korat, Matthias M. Herth, Bernd J. Pichler, Kristina Herfert, Andreas Maurer   +9 more
doaj   +1 more source