Results 101 to 110 of about 66,456,090 (253)

The Chicken Embryo: An Old but Promising Model for In Vivo Preclinical Research. [PDF]

Biomedicines
The chicken embryo has emerged as a valuable model for preclinical studies due to its unique combination of accessibility, affordability, and relevance to human biology.
Sarnella A, Ferrara Y, Terlizzi C, Albanese S, Monti S, Licenziato L, Mancini M.   +6 more
europepmc   +2 more sources

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Characterization of a Long-Acting Anti-Human MASP-2 Antibody for the Treatment of Complement-Related Diseases

Journal of Inflammation Research
Xiangli Han,1,2,* Changyong Yang,1,2,* Zhijun Wang,1,2,* Ke Fan,1,2 Kaili Liu,1,2 Hao Ye,1,2 Wei Zhang,1,2 Jiawei Zhang,1,2 Xiaotong Hu,1,2 Hongda Lin,1,2 Cheng Liao1,2 1Shanghai Shengdi Pharmaceutical Co., Ltd, Shanghai, 200100 ...
Han X, Yang C, Wang Z, Fan K, Liu K, Ye H, Zhang W, Zhang J, Hu X, Lin H, Liao C   +10 more
doaj  

Editorial: New trends in natural product research for inflammatory and infectious diseases

Frontiers in Pharmacology, 2022
Jaime Ribeiro-Filho, Yanna Carolina Ferreira Teles, John Ogbaji Igoli, Raffaele Capasso   +3 more
doaj   +1 more source

Value of preclinical systematic reviews and meta-analyses in pediatric research

Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current knowledge, possible gaps, and potential methodological flaws of study design, conduct, and report. One of the main
Malhotra, Atul,, Bruschettini, Matteo,, Lund University., Bank, Matthias,, Menon, Julia M L,, Romantsik, Olga,, Romantsik, Olga, Malhotra, Atul, Menon, Julia M L, Menon, Julia M. L., Bruschettini, Matteo, Bank, Matthias   +11 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Modified AAV5 capsid for improved brain biodistribution following direct injection in preclinical models

Molecular Therapy: Methods & Clinical Development
Gene therapies based on adeno-associated virus vectors hold strong potential for the treatment of central nervous system disorders. However, systemic delivery is limited by the blood-brain barrier, off-target effects, immune responses, and vector loss ...
Sebastian N. Kieper, Elisabeth A. Spronck, Meriem Bourajjaj, Roberto D.V.S. Morais, M. Leontien van der Bent, Seyda Acar Broekmans, Charlot van Rooijen, Rhodé van Westen, Giorgia Squeri, Giso Brasser, Morgane Wartel, Stijn J.H. Waaijer, C. Warner Hoornenborg, Tycho M. Hoogland, Richard Porter, Anggakusuma   +15 more
doaj   +1 more source

ACUTE STROKE MODELS USED IN PRECLINICAL RESEARCH [PDF]

, 2019
The success of developing new drugs largely depends on the methodology of preclinical research. For developing cerebroprotective drugs, there are many experimental models with different complexity. In this review the most used stroke models are described
A. A. Litvinov, E. V. Volotova, E. I. Morkovin, I. N. Tyurenkov, D. V. Kurkin, D. A. Bakulin, E. A. Logvinova   +6 more
core  

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source