Results 111 to 120 of about 777,237 (284)

An Overview of Investigational and Experimental Drug Treatment Strategies for Marfan Syndrome

Journal of Experimental Pharmacology, 2021
Violette Deleeuw, 1 Adelbert De Clercq, 1 Julie De Backer, 1, 2 Patrick Sips 1 1Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, 9000, Belgium; 2Department of Internal Medicine and Pediatrics, Ghent University ...
Deleeuw V, De Clercq A, De Backer J, Sips P   +3 more
doaj  

Postnatal maturation of the glomerular filtration rate in conventional growing piglets as potential juvenile animal model for preclinical pharmaceutical research [PDF]

, 2017
Adequate animal models are required to study the preclinical pharmacokinetics (PK), pharmacodynamics (PD) and safety of drugs in the pediatric subpopulation.
Croubels, Siska, Delanghe, Joris, Devreese, Mathias, Gasthuys, Elke, Heyndrickx, Marjolein, Millecam, Joske, Sys, Stanislas, Vande Walle, Johan, Vanderperren, Katrien   +8 more
core   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Preclinical Efficacy And Safety Evaluation of AAV‐OTOF in DFNB9 Mouse Model And Nonhuman Primate

Advanced Science
OTOF mutations are the principal causes of auditory neuropathy. There are reports on Otof‐related gene therapy in mice, but there is no preclinical research on the drug evaluations.
Jieyu Qi, Liyan Zhang, Fangzhi Tan, Yang Zhang, Yinyi Zhou, Ziyu Zhang, Hongyang Wang, Chaorong Yu, Lulu Jiang, Jiancheng Liu, Tian Chen, Lianqiu Wu, Shanzhong Zhang, Sijie Sun, Shan Sun, Ling Lu, Qiuju Wang, Renjie Chai   +17 more
doaj   +1 more source

Methods for Preclinical Assessment of the Efficacy of Anticancer Medicines in vivo (Review)

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. The main risk to the clinical translatability of preclinical results for anticancer medicinal products is posed by the difficulty of simulating clinical conditions in an experimental model.
M. L. Vasyutina, K. V. Lepik, M. S. Istomina, K. A. Levchuk, A. V. Petukhov, E. V. Shchelina, A. E. Ershova, O. N. Demidov, Ya. G. Toropova   +8 more
doaj   +1 more source

Moving forward to address key unanswered questions on targeting PD-1/PD-L1 in cancer: limitations in preclinical models and the need to incorporate human modifying factors. [PDF]

, 2019
The tremendous clinical success of immune checkpoint inhibition (ICI), particularly targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1/2 (PD-L1/2) pathway, has resulted in application to multiple cancers, as a monotherapy and ...
Le, Catherine T, Murphy, William J
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Characterization of a Long-Acting Anti-Human MASP-2 Antibody for the Treatment of Complement-Related Diseases

Journal of Inflammation Research
Xiangli Han,1,2,* Changyong Yang,1,2,* Zhijun Wang,1,2,* Ke Fan,1,2 Kaili Liu,1,2 Hao Ye,1,2 Wei Zhang,1,2 Jiawei Zhang,1,2 Xiaotong Hu,1,2 Hongda Lin,1,2 Cheng Liao1,2 1Shanghai Shengdi Pharmaceutical Co., Ltd, Shanghai, 200100 ...
Han X, Yang C, Wang Z, Fan K, Liu K, Ye H, Zhang W, Zhang J, Hu X, Lin H, Liao C   +10 more
doaj  

Preclinical PET and SPECT Imaging in Small Animals: Technologies, Challenges and Translational Impact

Cells
Molecular imaging in preclinical research using PET and SPECT has become a key component of contemporary biomedicine, enabling noninvasive, quantitative, and longitudinal assessment of biological processes in vivo. Rapid technological progress, including
Magdalena Bruzgo-Grzybko, Izabela Suwda Kalita, Adam Jan Olichwier, Natalia Bielicka, Ewa Chabielska, Anna Gromotowicz-Poplawska   +5 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source