Results 31 to 40 of about 777,237 (284)
Early affective changes and increased connectivity in preclinical Alzheimer's disease. [PDF]
, 2018 IntroductionAffective changes precede cognitive decline in mild Alzheimer's disease and may relate to increased connectivity in a "salience network" attuned to emotionally significant stimuli.
Bilgel, Murat +7 more
core +1 more source
Neuroinflammation in Preclinical Alzheimer's Disease: A Review of Current Evidence [PDF]
, 2018 The pathology of sporadic Alzheimer’s disease (AD) may be present at mid-life and precede the prodromal and clinical dementia syndromes associated with the disorder by decades.
Raymont, Vanessa +2 more
core +2 more sources
Preclinical Models for Bladder Cancer Research
Hematology/Oncology Clinics of North America, 2021 At diagnosis, more than 70% of bladder cancers (BCs) are at the non-muscle-invasive bladder cancer (NMIBC) stages, which are usually treated with transurethral resection followed by intravesical instillation. For the remaining advanced cancers, systemic therapy is the standard of care, with addition of radical cystectomy in cases of locally advanced ...
Zhu, Shaoming +5 more
openaire +4 more sources
Medical Sciences, 2019 Caroli syndrome, characterized by saccular dilatation of intrahepatic ducts and congenital hepatic fibrosis, is without therapy in part due to its ultra-rare prevalence and the apparent lack of availability of a suitable experimental model. While the PCK
Bharvi M. Chavre +8 more
doaj +1 more source
Frontiers in Immunology, 2022 Sustained complement activation is an underlying pathologic driver in many inflammatory and autoimmune diseases. Currently approved anti-complement therapies are directed at the systemic blockade of complement.
Kelly C. Fahnoe +11 more
doaj +1 more source
Predicting Alzheimer's risk: why and how? [PDF]
, 2011 Because the pathologic processes that underlie Alzheimer's disease (AD) appear to start 10 to 20 years before symptoms develop, there is currently intense interest in developing techniques to accurately predict which individuals are most likely to become
Barnes, Deborah E, Lee, Sei J
core +2 more sources
Brain amyloid in preclinical Alzheimer\u27s disease is associated with increased driving risk [PDF]
, 2016 INTRODUCTION: Postmortem studies suggest that fibrillar brain amyloid places people at higher risk for hazardous driving in the preclinical stage of Alzheimer's disease (AD). METHODS: We administered driving questionnaires to 104 older drivers (19 AD, 24
Bernier, Justine N +7 more
core +2 more sources
Fluoxetine: a case history of its discovery and preclinical development [PDF]
, 2014 Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N +20 more
core +2 more sources
Quality and validity of large animal experiments in stroke : a systematic review [PDF]
, 2020 An important factor for successful translational stroke research is study quality. Low-quality studies are at risk of biased results and effect overestimation, as has been intensely discussed for small animal stroke research.
Bahor, Z. +8 more
core +4 more sources
Regular medical checkup program (in K-MEDI hub) to enhance the welfare of laboratory dogs and pigs
Laboratory Animal Research, 2023 Background The importance of animal welfare is being recognized worldwide. Recently, the increasing demand for enhanced laboratory animal welfare has led to clinically featured transformations of animal research institutes.
Gwang-Hoon Lee +6 more
doaj +1 more source