Results 81 to 90 of about 808,538 (334)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Meta-analysis of preclinical studies of mesenchymal stromal cells to treat rheumatoid arthritis. [PDF]

, 2019
BackgroundThis study aims to evaluate the quality of preclinical data, determine the effect sizes, and identify experimental measures that inform efficacy using mesenchymal stromal (or stem) cells (MSC) therapy in animal models of rheumatoid arthritis ...
Farhoodi, Henry P, Han, Menglu, Liao, Wenbin, Liu, Guangyang, Liu, Linan, Liu, Yongjun, Wong, Chi W, Zhao, Weian   +7 more
core  

Neuroinflammatory targets and treatments for epilepsy validated in experimental models [PDF]

, 2017
A large body of evidence that has accumulated over the past decade strongly supports the role of inflammation in the pathophysiology of human epilepsy.
Aronica, Eleonora, Bauer, Sebastian, Bozzi, Yuri, Caleo, Matteo, Dingledine, Raymond, Gorter, Jan A., Henshall, David C., Kaminski, Rafal M., Kaufer, Daniela, Koh, Sookyong, Lã¶scher, Wolfgang, Louboutin, Jean-pierre, Mishto, Michele, Norwood, Braxton A., Palma, Eleonora, Poulter, Michael O., Terrone, Gaetano, Vezzani, Annamaria   +17 more
core   +5 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Vaccines with adjuvants. Preclinical studies

Биопрепараты: Профилактика, диагностика, лечение, 2018
The paper presents the data on safety and efficacy assessment of adjuvants and vaccines with adjuvants at the stages of development and preclinical studies based on international recommendations.
Zh. I. Avdeeva, N. A. Alpatova, V. P. Bondarev, R. A. Volkova, N. I. Lonskaya, E. V. Lebedinskaya, N. V. Medunitsyn, A. N. Mironov, N. A. Ozeretskovsky, A. A. Soldatov, V. A. Shevtsov   +10 more
doaj  

Methionine restriction for cancer therapy: From preclinical studies to clinical trials

Cancer Pathogenesis and Therapy
Methionine restriction (MR) has shown significant promise in cancer therapy because it targets the unique methionine dependency of many tumors. However, despite extensive research on MR, a clear synthesis of preclinical findings and their translation ...
Nagaraju Bandaru, Shaik Mohammad Noor, Maha Lakshmi Kammili, Mohan Gandhi Bonthu, Alluri Pavani Gayatri, Perli Kranti Kumar   +5 more
doaj   +1 more source

Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors. [PDF]

, 2019
Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies.
Abrams, Gary, Chesney, Margaret, Conley, Yvette P, Kober, Kord M, Levine, Jon D, Melisko, Michelle, Miaskowski, Christine, Paul, Steven M, Schumacher, Mark, Topp, Kimberly   +9 more
core  

Predicting Alzheimer's risk: why and how? [PDF]

, 2011
Because the pathologic processes that underlie Alzheimer's disease (AD) appear to start 10 to 20 years before symptoms develop, there is currently intense interest in developing techniques to accurately predict which individuals are most likely to become
Barnes, Deborah E, Lee, Sei J
core   +2 more sources

Preclinical Studies with Digitalis Lanata: A Bibliographic Review [PDF]

, 2022
Garcia Metz Soraya Katine
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source