Results 111 to 120 of about 54,023 (335)

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

open access: yesAdvanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård   +19 more
wiley   +1 more source

18β‐Glycyrrhetinic Acid and a Nano‐Liposomal Formulation Alleviate Depression‐Like Behaviors via the Microglial mTOR‐Autophagy‐NLRP3 Axis

open access: yesAdvanced Science, EarlyView.
Using a novel zebrafish‐based inflammatory screening strategy, we screened and identified 18β‐glycyrrhetinic acid (18β‐GA) as a promising anti‐inflammatory candidate. We uncover a microglial mTOR–autophagy–NLRP3 axis that constitutes the mechanistic core of 18β‐GA–mediated neuroprotection.
Hua Gan   +11 more
wiley   +1 more source

Parallel RFSAI-BFGS Preconditioners for Large Symmetric Eigenproblems

open access: yesJournal of Applied Mathematics, 2013
We propose a parallel preconditioner for the Newton method in the computation of the leftmost eigenpairs of large and sparse symmetric positive definite matrices.
L. Bergamaschi, A. Martínez
doaj   +1 more source

Biolipid Film‐Fused Electrochemiluminescence for Multipurpose In Situ Bioassays

open access: yesAdvanced Science, EarlyView.
An ECL‐emissive, membrane‐interactive scaffold was fabricated, and facilely fused with natural and non‐native phospholipids into multifactorial mimicries of cytomembranes and vesicles for in vitro representative membrane‐process probing. Such a biointerface‐based, state‐sensitive ECL paradigm not only pinpointed proximal phenomena, including channeling
Jialiang Chen   +9 more
wiley   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

open access: yesAdvanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong   +8 more
wiley   +1 more source

Overlapping Schwarz Preconditioners for Isogeometric Collocation Methods Based on Generalized B-Splines

open access: yesAxioms
We study overlapping additive Schwarz (OAS) preconditioners for the solution of elliptic boundary value problems discretized using isogeometric collocation methods based on generalized B-splines (GB-splines). Through a series of numerical experiments, we
Durkbin Cho
doaj   +1 more source

A Rapid Numerical Algorithm to Compute Matrix Inversion

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2012
The aim of the present work is to suggest and establish a numerical algorithm based on matrix multiplications for computing approximate inverses. It is shown theoretically that the scheme possesses seventh-order convergence, and thus it rapidly converges.
F. Soleymani
doaj   +1 more source

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