Results 1 to 10 of about 79,595 (220)

Precursor NK cell lymphoblastic leukemia/lymphoma - report of a case with literature review [PDF]

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Precursor Natural Killer cell lymphoblastic leukemia/lymphoma is a rare entity defined clearly by WHO (2008 WHO classification). However, the pathobiology of this subset of neoplasms is not clearly defined.
Sonal Jain, Rajeev Kumar, Abhishek Purohit, Hara Prasad Pati   +3 more
doaj   +6 more sources

Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report [PDF]

Case Reports in Pathology, 2013
Acute lymphoblastic leukemia is predominantly found in children. It is a neoplasm of precursor cells or lymphoblasts committed to either a B- or T-cell lineage.
Alicia C. Hirzel, Aaron Cotrell, Robert Gasparini, Vathany Sriganeshan   +3 more
doaj   +7 more sources

Haploidentical CD7 CAR T-cells induced remission in a patient with TP53 mutated relapsed and refractory early T-cell precursor lymphoblastic leukemia/lymphoma [PDF]

Biomarker Research, 2022
AbstractPatients with relapsed/refractory early T-cell precursor lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) respond poorly to traditional therapy and have dismal prognosis. CD7 is a promising therapeutic targets for chimeric antigen receptor modified T cell therapy (CART) due to its widely expression in almost all T-cell malignancies.
Haiping Dai, Wei Cui, Qingya Cui, Wenjuan Zhu, Huimin Meng, Min-qing Zhu, Xiaming Zhu, Lin Yang, Depei Wu, Xiaowen Tang   +9 more
semanticscholar   +5 more sources

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma [PDF]

Blood, 2009
Abstract The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions.
Ying-Wei Lin, Zanna Beharry, Elizabeth G. Hill, Jin H. Song, Wenxue Wang, Zuping Xia, Zhenhua Zhang, Peter D. Aplan, Jon C. Aster, Charles D. Smith, Andrew S. Kraft   +10 more
semanticscholar   +7 more sources

Emerging Necessity of Myeloid Mutational Analysis in Early T-cell Precursor Acute Lymphoblastic Leukemia/Lymphoma (ETP-ALL)

Turkish Journal of Hematology, 2023
Early T-cell precursor (ETP) acute lymphoblastic leukemia/ lymphoma (ETP-ALL) is a unique subtype of T-lymphoblastic leukemia (T-ALL) characterized by its distinct immunophenotypic profile and genetic signature. First described in 2009 as a type of T-ALL
Hamza Tariq, Sindhu Shetty
semanticscholar   +5 more sources

Gene expression profiling of precursor T-cell lymphoblastic leukemia/lymphoma identifies oncogenic pathways that are potential therapeutic targets [PDF]

Leukemia, 2007
We compared the gene expression pattern of thymic tumors from precursor T-cell lymphoblastic lymphoma/leukemia (pre-T LBL) that arose in transgenic mice that overexpressed SCL, LMO1 or NUP98-HOXD13 (NHD13) with that of thymocytes from normal littermates.
Y-W Lin, PD Aplan
semanticscholar   +6 more sources

An unusual presentation of precursor T cell lymphoblastic leukemia/lymphoma with cholestatic jaundice: case report [PDF]

Journal of Hematology & Oncology, 2009
Cholestatic jaundice as a presenting symptom of Precursor T-lymphoblastic leukemia (T-ALL)/lymphoma (T-LBL) has never been reported in literature. Similarly, precursor T-ALL/T-LBL is characteristically negative for synaptophysin. We report the first case of a patient with precursor T-ALL/T-LBL who presented with cholestatic jaundice and aberrant tumor ...
Kevin Patel, Sahibzada U. Latif, Wanderley M de Calaca   +2 more
semanticscholar   +7 more sources

Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) in adolescents and adults: a high-risk subtype [PDF]

Blood, 2016
Key Points Adult patients with ETP-ALL/LBL have poor long-term outcomes. Novel therapies are urgently needed for adult patients with ETP-ALL/LBL.
Nitin Jain, Audrey Lamb, Susan O’Brien, Farhad Ravandi, Marina Konopleva, Elias Jabbour, Zhuang Zuo, Jeffrey L. Jorgensen, Pei Lin, Sherry Pierce, Deborah Thomas, Michael Rytting, Gautam Borthakur, Tapan M. Kadia, Jorge E. Cortés, Hagop M. Kantarjian, Joseph D. Khoury   +16 more
semanticscholar   +5 more sources

PB1754: HOMOZYGOUS DELETION OF ETV6: EARLY T-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA OR PRECURSOR T-LYMPHOBLASTIC LYMPHOMA

HemaSphere, 2023
Precursor T-lymphoblastic lymphoma (T-LBL), which is biologically similar to precursor T-acute lymphoblastic leukemia (T-ALL), is derived from immature lymphoid cells of T-cell lineage.
Miguel Ángel Perera Álvarez, Juan Francisco Rodríguez López, Jorge Rodríguez-Afonso, Paula Reyes-González-Casanova, Dolly Viviana Fiallo Suarez, Maria Angelina Lemes Castellano, Maria Violeta Vidal Ballester, Ruth Stuckey, Carlos Rodriguez Medina, Cristina Bilbao, Maria Teresa Gomez Casares   +10 more
doaj   +3 more sources

Haplo-Identical Non-Gene Editing CD7 CAR T-Cells Induced Bone Marrow and Extramedullary Remission in a Pediatric Patient with TP53 Mutated Relapsed and Refractory Early T-Cell Precursor Lymphoblastic Leukemia/Lymphoma after Haploidentical Hematopoietic Stem Cell Transplantation

Blood, 2021
Abstract Patients with relapsed/refractory early T-cell precursor lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) respond poorly to traditional therapy and have dismal prognosis. CD7 expresses in almost all blasts of T-cell lymphoma/leukemia and represents one of the most promising therapeutic targets for T-ALL/LBL by CD7 targeted chimeric
Haiping Dai, Yang Lin, Huimin Meng, Qingya Cui, Wenjuan Zhu, Xiaowen Tang, Wei Cui, Depei Wu   +7 more
semanticscholar   +4 more sources