Results 41 to 50 of about 12,114 (185)

Secondary acute lymphoblastic leukemia is a distinct clinical entity with prognostic significance. [PDF]

, 2017
The effect of prior malignancy on the risk of developing, and prognosis of, acute lymphoblastic leukemia (ALL) is unknown. This observational study utilized the California Cancer Registry to estimate the risk of developing ALL after a prior malignancy ...
Brunson, A, Jonas, BA, Keegan, THM, Paulus, JK, Rosenberg, AS, Tuscano, J, Wun, T   +6 more
core   +2 more sources

Role of enhancer of zeste homolog 2 polycomb protein and its significance in tumor progression and cell differentiation [PDF]

, 2013
Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2].
Bagella, Luigi Marco, Marchesi, Irene
core   +2 more sources

Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case

Oral Oncology Reports
B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a type of malignancy involving uncontrolled proliferation of B-precursor lymphoid cells. This case report delineates B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) manifesting in the mandible and ...
Paulo Victor Mendes Penafort, Lady Paola Aristizabal Arboleda, Sérgio Takashi Kussaba, Izilda Aparecida Cardinalli, Regina Maria Holanda de Mendonça, Márcio Ajudarte Lopes, Pablo Agustin Vargas, Alan Roger Santos-Silva   +7 more
doaj   +1 more source

Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review

Case Reports in Hematology, 2019
Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement.
Sharad Khurana, Manuel Beltran, Liuyan Jiang, Ernesto Ayala, Vivek Roy   +4 more
doaj   +1 more source

Candida on oral cavity of pediatric individuals with ALL and its susceptibility to nystatin and amphotericin B

RGO: Revista Gaúcha de Odontologia, 2019
Objective: The aim of this study was to evaluate the prevalence of Candida colonizationon oral cavity of pediatric individuals with acute lymphocytic leukemia (ALL) and its susceptibility/resistance to nystatin and amphotericin B.
Larissa Cavalcanti MONTEIRO, Isabella Lima Arrais RIBEIRO, Roberta Ferreti Bonan Dantas BATISTA, Panmella Pereira MACIEL, Ana Maria Gondim VALENÇA, Ana Carolina Bernardes DULGHEROFF4 , Joelma Rodrigues SOUZA, Yuri Wanderley CAVALCANTI1 , Lucio Roberto Cançado CASTELLANO, Paulo Rogério Ferreti BONAN   +9 more
doaj   +1 more source

Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms. [PDF]

, 2018
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of ...
Aliberti S, Bareja R, Bonvini E, Bruna R, Brusa D, Chiaretti S, Chichili GR, Cignetti A, Circosta P, Deaglio S, Elemento O, Elia AR, Foà R, Giacomo FD, Gottardi D, Guarini AR, Inghirami G., Johnson S, Kyriakides PW, Landra I, Machiorlatti R, Massaia M, Monteleone E, Moore PA, Todaro M   +24 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia [PDF]

, 2017
BACKGROUND Blinatumomab, a bispecific monoclonal antibody construct that enables CD3-positive T cells to recognize and eliminate CD19-positive acute lymphoblastic leukemia (ALL) blasts, was approved for use in patients with relapsed or refractory B ...
Arslan, O, Bassan, R, Bergeron, J, Brueggemann, M, Demirkan, F, Dombret, H, Fielding, AK, Fleishman, A, Foa, R, Goekbuget, N, Holland, C, Horst, H-A, Kantarjian, H, Klapper, W, Lech-Maranda, E, Nagorsen, D, Rambaldi, A, Ribera, J-M, Sanz, MA, Schuh, AC, Stein, A, Thomas, X, Topp, MS, Wei, A, Wood, BL, Zimmerman, Z   +25 more
core   +3 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV)

Онкогематология, 2018
Introduction. Surface immunoglobulin expression is a main immunophenotypic criteria of mature subtype of B-lineage acute lymphoblastic leukemia. Although the majority of such cases represents Burkitt leukemia/lymphoma, it was shown for several times that
I. A. Demina, Т. Yu. Verzhbitskaya, S. A. Kashpor, L. V. Baidun, T. V. Koniuhova, S. A. Plyasunova, G. А. Tsaur, E. B. Rusanova, M. V. Gorchakova, E. E. Zueva, A. N. Kazakova, E. A. Zerkalenkova, Yu. V. Olshanskaya, Yu. G. Abugova, L. G. Fechina, N. V. Miakova, E. V. Samochatova, А. А. Maschan, А. M. Popov   +18 more
doaj   +1 more source