Results 81 to 90 of about 59,825 (253)

HETEROGENEITY OF CHILDHOOD B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (EGIL SUBTYPE BIV)

Онкогематология, 2018
Introduction. Surface immunoglobulin expression is a main immunophenotypic criteria of mature subtype of B-lineage acute lymphoblastic leukemia. Although the majority of such cases represents Burkitt leukemia/lymphoma, it was shown for several times that
I. A. Demina, Т. Yu. Verzhbitskaya, S. A. Kashpor, L. V. Baidun, T. V. Koniuhova, S. A. Plyasunova, G. А. Tsaur, E. B. Rusanova, M. V. Gorchakova, E. E. Zueva, A. N. Kazakova, E. A. Zerkalenkova, Yu. V. Olshanskaya, Yu. G. Abugova, L. G. Fechina, N. V. Miakova, E. V. Samochatova, А. А. Maschan, А. M. Popov   +18 more
doaj   +1 more source

Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia [PDF]

, 2017
BACKGROUND Blinatumomab, a bispecific monoclonal antibody construct that enables CD3-positive T cells to recognize and eliminate CD19-positive acute lymphoblastic leukemia (ALL) blasts, was approved for use in patients with relapsed or refractory B ...
Arslan, O, Bassan, R, Bergeron, J, Brueggemann, M, Demirkan, F, Dombret, H, Fielding, AK, Fleishman, A, Foa, R, Goekbuget, N, Holland, C, Horst, H-A, Kantarjian, H, Klapper, W, Lech-Maranda, E, Nagorsen, D, Rambaldi, A, Ribera, J-M, Sanz, MA, Schuh, AC, Stein, A, Thomas, X, Topp, MS, Wei, A, Wood, BL, Zimmerman, Z   +25 more
core   +3 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms [PDF]

, 2019
ZEB1 and ZEB2 are structurally related E-box binding homeobox transcription factors that induce epithelial to mesenchymal transitions during development and disease.
Berx, Geert, Curtis, David J, De Medts, Jelle, Goossens, Steven, Haigh, Jody J, Haigh, Katharina, Nguyen, Thao, Saw, Jesslyn, T'Sas, Sara, Taghon, Tom, Tremblay, Cedric, Van Vlierberghe, Pieter, Wang, Jueqiong   +12 more
core   +15 more sources

Diagnostic challenges in a case of B cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma [PDF]

, 2013
postprin
Chu, ML, So, JCC, Wan, TSK, Yung, KH
core   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Gum hypertrophy - an unusual presenting feature in a case of precursor T-cell acute lymphoblastic leukemia

Turkish Journal of Hematology, 2008
Acute lymphoblastic leukemia/lymphoma, the malignant transformation of T-cell or B-cell precursors, is the most common diagnosis in pediatric oncology. Precursor T-cell acute lymphoblastic leukemia/lymphoma commonly affects adolescents, and is associated
Lingappa Appaji, Rudramurthy Pradeep, Vishweshwariah Lakshmidevi, Davanam Satyanarayana Madhumati, Chennagiri Srinivasamurthy Premalata, Geetashree Mukherjee   +5 more
doaj  

Beyond CD19: Opportunities for Future Development of Targeted Immunotherapy in Pediatric Relapsed-Refractory Acute Leukemia [PDF]

, 2015
Chimeric antigen receptor (CAR) T cell therapy has been used as a targeted approach in cancer therapy. Relapsed and refractory acute leukemia in pediatrics has been difficult to treat with conventional therapy due to dose limiting toxicities.
Anne Angiolillo, Haneen Shalabi, Terry J. Fry   +2 more
core   +3 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

MicroRNAs in B cell development and malignancy [PDF]

, 2012
MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and ...
Fernando, Thilini R., Rao, Dinesh S., Rodriguez-Malave, Norma I.   +2 more
core   +4 more sources