Results 81 to 90 of about 12,114 (185)

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, Volume 45, Issue 6, Page 1547-1563, November 2025.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Acute Lymphoblastic Leukemia Presenting as Acute Vogt-Koyanagi-Harada Syndrome

Case Reports in Ophthalmology, 2020
We aimed to describe a case of acute lymphoblastic leukemia (ALL) that initially presented and was managed as Vogt-Koyanagi-Harada syndrome (VKH). A 62-year-old man was referred for vision loss starting 1 week ago.
Narges Hassanpoor, Mohamad Reza Niyousha   +1 more
doaj   +1 more source

Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34+ progenitor cells during differentiation into antigen presenting cells [PDF]

, 2001
The inducible costimulator receptor (ICOS) is a third member of the CD28 receptor family that regulates T cell activation and function. ICOS binds to a newly identified ligand on antigen presenting cells different from the CD152 ligands CD80 and CD86. We
Aicher, A, Clark, EA, Daemen, K, Hayden-Ledbetter, M, Irgang, M, Korner, I, Ledbetter, JA, Pezzutto, A, Richter, G, Westermann, J   +9 more
core  

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia [PDF]

, 2015
Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent ...
ALLEGRETTI, MATTEO, Bergamo, P, FOA, Roberto, Iacovelli, S, LICCHETTA, ROBERTO, Martelli, Am, Mccubrey, Ja, Milella, M, MIRABILII, SIMONE, RICCIARDI, Maria Rosaria, Rinaldo, C, TAFURI, Agostino, Zeuner, A   +12 more
core   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

Synergism between the mTOR inhibitor rapamycin and FAK down-regulation in the treatment of acute lymphoblastic leukemia

Journal of Hematology & Oncology, 2016
Background Acute lymphoblastic leukemia (ALL) is an aggressive malignant disorder of lymphoid progenitor cells in both children and adults. Although improvements in contemporary therapy and development of new treatment strategies have led to dramatic ...
Pei-Jie Shi, Lu-Hong Xu, Kang-Yu Lin, Wen-jun Weng, Jian-Pei Fang   +4 more
doaj   +1 more source

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia [PDF]

, 2016
Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical ...
Abonour, Rafat, Anderson, Kenneth C., Ansell, Stephen M., Avigan, David, Barbarotta, Lisa, Barrett, Austin John, Bergsagel, Leif, Bishop, Michael R., Borrello, Ivan, Boyiadzis, Michael, Brody, Joshua, Brufsky, Jill, Cairo, Mitchell, Chari, Ajai, Cohen, Adam, Cortes, Jorge, de Lima, Marcos, Dhodapkar, Madhav V., Forman, Stephen J., Friedberg, Jonathan W., Fuchs, Ephraim J., Gore, Steven D., Jagannath, Sundar, Kahl, Brad S, Kline, Justin, Kochenderfer, James N., Kwak, Larry W., Levy, Ronald, Litzow, Mark R., Mahindra, Anuj, Miller, Jeffrey, Munshi, Nikhil C., Orlowski, Robert Z., Pagel, John M., Porter, David L., Russell, Stephen J., Schwartz, Karl, Shipp, Margaret A., Siegel, David, Stone, Richard M., Tallman, Martin S., Timmerman, John M., Van Besien, Koen, Van Rhee, Frits, Waller, Edmund K., Welsh, Ann, Werner, Michael, Wiernik, Peter H.   +47 more
core   +2 more sources

The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes

International Journal of Cancer, Volume 157, Issue 8, Page 1600-1612, 15 October 2025.
What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville, Lisa J. Russell, Kay Padget, Akram Ghantous, Jessica Nordlund, Jill A. McKay   +5 more
wiley   +1 more source

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]

, 2016
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe, Barzilai, Shlomit, Escherich, Gabriele, Frandsen, Thomas Leth, Halsey, Christina, Hough, Rachael, Jeha, Sima, Kato, Motohiro, Liang, Der-Cherng, Mikkelsen, Torben Stamm, Moricke, Anja, Niinimaki, Riitta, Piette, Caroline, Putti, Maria Caterina, Raetz, Elizabeth, Schmiegelow, Kjeld, Silverman, Lewis B., Skinner, Roderick, Tuckuviene, Ruta, van der Sluis, Inge, Zapotocka, Ester   +20 more
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, Volume 599, Issue 20, Page 2911-2931, October 2025.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source