Results 11 to 20 of about 50,528 (188)

Haplo-Identical Non-Gene Editing CD7 CAR T-Cells Induced Bone Marrow and Extramedullary Remission in a Pediatric Patient with TP53 Mutated Relapsed and Refractory Early T-Cell Precursor Lymphoblastic Leukemia/Lymphoma after Haploidentical Hematopoietic Stem Cell Transplantation

Blood, 2021
Abstract Patients with relapsed/refractory early T-cell precursor lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) respond poorly to traditional therapy and have dismal prognosis. CD7 expresses in almost all blasts of T-cell lymphoma/leukemia and represents one of the most promising therapeutic targets for T-ALL/LBL by CD7 targeted chimeric
Huimin Meng, Yang Lin, Wei Cui, Qingya Cui, Depei Wu, Xiaowen Tang, Haiping Dai, Wenjuan Zhu   +7 more
semanticscholar   +4 more sources

Synchronous childhood T-lymphoblastic lymphoma and B-cell precursor acute lymphoblastic leukemia associated with constitutional MMR deficiency syndrome –a case report

Frontiers in Oncology
We present a four-year-old girl with synchronous T-cell lymphoblastic lymphoma (T-LBL) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL).Development of two lymphoid malignancies arising from completely different cell lineages was confirmed by ...
Joanna Bulsa, Agata Karolina Pastorczak, Joanna Taha, Wojciech Mlynarski, Łukasz Sędek, Tomasz Szczepanski   +5 more
doaj   +3 more sources

Frequency and clinical relevance of DNA microsatellite alterations of the CDKN2A/B, ATM and p53 gene loci: a comparison between pediatric precursor T-cell lymphoblastic lymphoma and T-cell lymphoblastic leukemia

Haematologica, 2010
Although deletions of cell cycle regulatory gene loci have long been reported in various malignancies, little is known regarding their relevance in pediatric T-cell lymphoblastic lymphoma (T-LBL) and T-cell lymphoblastic leukemia (TALL).
David Krieger, Anja Moericke, Ilske Oschlies, Martin Zimmermann, Martin Schrappe, Alfred Reiter, Birgit Burkhardt   +6 more
doaj   +4 more sources

ABL oncogene amplification with p16^INK4a gene deletion in precursor T‐cell acute lymphoblastic leukemia/lymphoma: Report of the first case [PDF]

American Journal of Hematology, 2004
AbstractGene amplification is a relatively rare event in hematologic malignancies. The ABL gene on chromosome band 9q34 is a proto‐oncogene and is the well‐known translocation partner of the BCR gene on 22q11 giving rise to t(9;22)(q34;q11), which is the hallmark of chronic myeloid leukemia and is the most common chromosomal abnormality in adult acute ...
Koo Hh, Hee Jin Kim, Sun-Hee Kim, Eun-Young Tak, Hee-Yeon Woo   +4 more
semanticscholar   +4 more sources

Outcome of Patients with T-Cell Acute Lymphoblastic Leukemia/Lymphoma with Early T-Cell Precursor-like Immunophenotype with Strong CD5 Expression

Blood, 2020
Introduction: T-cell acute lymphoblastic leukemia (T-ALL) originating from early T-cell precursors (ETP-ALL) has distinct immunophenotype (CD1a-CD8-CD5-/weak and positive for myeloid or stem-cell markers [My-HSC+]) and is associated with poor outcome with 5-year (yr) survival <25%. Some T-ALL cases are transcriptionally similar to
Nicholas J. Short, Feng Wang, Courtney D. DiNardo, Kiyomi Morita, Hong Fang, Naval Daver, Tapan M. Kadia, Marina Konopleva, Rita Khouri, Hagop M. Kantarjian, Farhad Ravandi, El Hussein Siba, Joseph D. Khoury, Koichi Takahashi, Koji Sasaki, Sergej Konoplev, Guillermo Montalban Bravo, Nitin Jain, Elias Jabbour, Guillermo Garcia-Manero   +19 more
semanticscholar   +4 more sources

Multi-Institution Review of Adult Early T-Cell Precursor Acute Lymphoblastic Leukemia/Lymphoma (ETP-ALL)

Blood, 2015
Abstract Background: The Early T-cell precursor (ETP) variant of acute lymphoblastic lymphoma/leukemia (ALL) is a recognized high risk variant, recognized by the absence of CD1a, with aberrant myeloid antigen expression (CD13, CD33, CD117, and CD34), and frequent absence of CD4 or CD8. Treatment intensification may improve
Deniz Peker, Bijal D. Shah, Julio C. Chavez, Vamsi Kota, Amanda Redden Hathaway, Uma Borate, Ling Zhang   +6 more
semanticscholar   +4 more sources

Flow cytometry in the differential diagnosis of lymphocyte-rich thymoma from precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma. [PDF]

American Journal of Clinical Pathology, 2004
We compared the antigen expression profile of thymocytes in lymphocyte-rich thymoma with that of precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-cell ALL/LBL) cells using 4-colorflow cytometry.
Shiyong Li, J. Juco, K. Mann, J. Holden
semanticscholar   +3 more sources

Phosphoproteomic Analysis Reveals a Different Proteomic Profile in Pediatric Patients With T-Cell Lymphoblastic Lymphoma or T-Cell Acute Lymphoblastic Leukemia

Frontiers in Oncology, 2022
T-cell lymphoblastic lymphoma (T-LBL) and lymphoblastic leukemia (T-ALL) arise from the transformation of precursor T-cells sharing common morphological and immunophenotypic features.
Giulia Veltri, Giulia Veltri, Federica Lovisa, Giuliana Cortese, Marta Pillon, Elisa Carraro, Simone Cesaro, Massimo Provenzi, Salvatore Buffardi, Samuela Francescato, Alessandra Biffi, Alessandra Biffi, Barbara Buldini, Barbara Buldini, Valentino Conter, Valentina Serafin, Valentina Serafin, Lara Mussolin, Lara Mussolin   +18 more
doaj   +2 more sources

Secondary Precursor T-Cell Lymphoblastic Lymphoma Following Precursor B-cell Acute Lymphoblastic Leukemia: A Case Report and Review of the Literature

, 2014
Although relapse of lymphoma/leukemia is not uncommon, sequential development of a second lymphoma/leukemia of a different cell lineage is rare. We report the case of a 3-year-old girl who initially presented with precursor B-cell acute lymphoblastic ...
Jenny L. Smith, A. Kheradpour, C. Zuppan, Jun Wang, R. Ketterling, E. Rowsell   +5 more
semanticscholar   +3 more sources

Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. [PDF]

American Journal of Clinical Pathology, 2007
Session 4 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop focused on case presentations of precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (pre-T ALL/LBL) and acute biphenotypic leukemia. Pre-
Xin Han, C. Bueso-Ramos
semanticscholar   +3 more sources