Cytometry Part B: Clinical Cytometry, EarlyView.Abstract Measurable residual disease (MRD) monitoring by multiparameter flow cytometry (MFC) is well established in bone marrow (BM) samples for acute myeloid leukemia (AML), but its use in peripheral blood (PB) remains less developed. We adapted a semi‐automated and well validated MFC‐MRD assay, originally developed for BM, to PB aiming to evaluate ...
Jonas Schadt +8 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Diagnostic challenges in a case of B cell lymphoma unclassifiable with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma [PDF]
, 2013 postprin
Chu, ML, So, JCC, Wan, TSK, Yung, KH
core +1 more source
Genetic analysis of primary lung interdigitating dendritic cell sarcomas
The Journal of Pathology, EarlyView.Abstract Interdigitating dendritic cell sarcomas (IDCSs) are rare tumors that commonly arise in the hematopoietic system and rarely outside. The genetic drivers of IDCS carcinogenesis are unknown; therefore, therapeutic options are limited. We investigated somatic gene mutations and copy‐number alterations (CNAs) in nine IDCSs arising in the lung by ...
Mikhail S Ermakov +6 more
wiley +1 more source
Secondary acute lymphoblastic leukemia is a distinct clinical entity with prognostic significance. [PDF]
, 2017 The effect of prior malignancy on the risk of developing, and prognosis of, acute lymphoblastic leukemia (ALL) is unknown. This observational study utilized the California Cancer Registry to estimate the risk of developing ALL after a prior malignancy ...
Brunson, A +6 more
core +2 more sources
Oral Mucositis in Oncopediatric Patients: MTX and MMP‐1, MMP‐8, MMP‐13 Gene Polymorphisms
Oral Diseases, EarlyView.ABSTRACT Background This study investigates the association between single‐nucleotide polymorphisms (SNPs) in the MMP‐1, MMP‐8, and MMP‐13 genes and the risk of oral mucositis development in paediatric patients with leukaemia and lymphoma who are undergoing methotrexate (MTX) treatment.
Nicole Januário Ribeiro +6 more
wiley +1 more source
Metabolic gatekeeper function of B-lymphoid transcription factors. [PDF]
, 2017 B-lymphoid transcription factors, such as PAX5 and IKZF1, are critical for early B-cell development, yet lesions of the genes encoding these transcription factors occur in over 80% of cases of pre-B-cell acute lymphoblastic leukaemia (ALL).
Borkhardt, Arndt +26 more
core
Beyond CD19: Opportunities for Future Development of Targeted Immunotherapy in Pediatric Relapsed-Refractory Acute Leukemia [PDF]
, 2015 Chimeric antigen receptor (CAR) T cell therapy has been used as a targeted approach in cancer therapy. Relapsed and refractory acute leukemia in pediatrics has been difficult to treat with conventional therapy due to dose limiting toxicities.
Anne Angiolillo +2 more
core +3 more sources
Impaired hematopoiesis affects apheresis and CAR T‐cell product composition and treatment response
Transfusion, EarlyView.Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of hematologic malignancies, but its success depends on obtaining sufficient CD3+ T‐cell yields during leukapheresis. This can be difficult in heavily pretreated patients, who often show leukopenia and reduced T‐cell fitness.
Hanna Kuhn +14 more
wiley +1 more source
Detecção de doença residual mínima em crianças com leucemia linfoblástica aguda por citometria de fluxo [PDF]
, 2008 The detection of minimal residual disease (MRD) is an important prognostic factor in childhood acute lymphoblastic leukemia (ALL) providing crucial information on the response to treatment and risk of relapse.
BRAGA, Josefina A. P. +6 more
core +2 more sources