Results 41 to 50 of about 31,911 (153)

Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review

Case Reports in Hematology, 2019
Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement.
Sharad Khurana, Manuel Beltran, Liuyan Jiang, Ernesto Ayala, Vivek Roy   +4 more
doaj   +1 more source

Myeloid/lymphoid neoplasm with eosinophilia and BCR/FGFR1 rearrangement with transformation to cortical T-lymphoblastic lymphoma and erythroid precursors: a case report

Journal of Medical Case Reports, 2023
Background Myeloproliferative neoplasms are a group of diseases with diverse biological and clinical characteristics. As a provisional separate entity, myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangement have been described, which may ...
Alejandro Pineda Isaza, Santiago Castaño Quintero, Lisceth Paola Quintero González, Fabián Emiliano Ahumada Córdoba, Andrés Felipe Arbeláez Olivar, Juan Carlos Bravo Ocaña   +5 more
doaj   +1 more source

CAR T-cell therapy-transforming treatment of hematological malignancies

Asian Journal of Medical Sciences, 2023
Hematological malignancies are a significant cause of mortality and morbidity in all age groups. According to the Global Burden of Disease Cancer Collaboration, there were about one million incident cases of hematological malignancies worldwide in 2016 ...
Shah Newaz Ahmed , Arun Kumar
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Synchronous childhood T-lymphoblastic lymphoma and B-cell precursor acute lymphoblastic leukemia associated with constitutional MMR deficiency syndrome –a case report

Frontiers in Oncology
We present a four-year-old girl with synchronous T-cell lymphoblastic lymphoma (T-LBL) and B-cell precursor acute lymphoblastic leukemia (BCP-ALL).Development of two lymphoid malignancies arising from completely different cell lineages was confirmed by ...
Joanna Bulsa, Agata Karolina Pastorczak, Joanna Taha, Wojciech Mlynarski, Łukasz Sędek, Tomasz Szczepanski   +5 more
doaj   +1 more source

γδ T-Cell Acute Lymphoblastic Leukemia/Lymphoma: Discussion of Two Pediatric Cases and Its Distinction from Other Mature γδ T-Cell Malignancies

Case Reports in Hematology, 2017
Gamma delta (γδ) T-cell antigen receptor (TCR) expression and its related T-cell differentiation are not commonly reported in T-cell acute lymphoblastic leukemia/lymphoma (T-ALL).
Eric X. Wei, Vasiliki Leventaki, John K. Choi, Susana C. Raimondi, Elizabeth M. Azzato, Sheila A. Shurtleff, Menchu G. Ong, Diana M. Veillon, James D. Cotelingam, Rodney E. Shackelford   +9 more
doaj   +1 more source

Chimeric Antigen Receptor Based Cellular Therapy for Treatment Of T-Cell Malignancies

Frontiers in Oncology, 2022
T-cell malignancies can be divided into precursor (T-acute lymphoblastic leukemia/lymphoblastic lymphoma, T-ALL/LBL) and mature T-cell neoplasms, which are comprised of 28 different entities.
Kamila Polgárová, Kamila Polgárová, Pavel Otáhal, Cyril Šálek, Cyril Šálek, Robert Pytlík, Robert Pytlík   +6 more
doaj   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Rapid Progression of Mediastinal Tumor within a Few Days: A Case Report of T Cell Lymphoblastic Lymphoma

대한영상의학회지, 2016
T-cell lymphoblastic lymphoma is a highly aggressive tumor derived from lymphocyte of the thymus, which accounts for 2% of non-Hodgkin's lymphoma. The disease occurs most commonly in adolescent and young adult males.
Tae Ran Ahn, Young Kyung Lee, Hyun Jung Jun, Eun Ah Jung, Jin Sung Son   +4 more
doaj   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source