Results 31 to 40 of about 31,911 (153)

Aberrant positivity for CD79a in erythroid lineage cells – a finding observed in a subset of re-staging bone marrow trephine biopsies after treatment

Haematologica, 2007
Aberrant expression of CD79a has been reported in neoplastic cells in peripheral T cell lymphoma, T-cell acute lymphoblastic leukemia and acute myeloid leukemia (especially those with t(8;21)).
Rashpal Singh Flora, Finella Brito-Babapulle, Kikkeri N. Naresh   +2 more
doaj   +1 more source

Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report

Case Reports in Pathology, 2013
Acute lymphoblastic leukemia is predominantly found in children. It is a neoplasm of precursor cells or lymphoblasts committed to either a B- or T-cell lineage.
Alicia C. Hirzel, Aaron Cotrell, Robert Gasparini, Vathany Sriganeshan   +3 more
doaj   +1 more source

Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion

Haematologica, 2019
Fusion genes involving MEF2D have recently been identified in precursor B-cell acute lymphoblastic leukemia, mutually exclusive of the common risk stratifying genetic abnormalities, although their true incidence and associated clinical characteristics ...
Kentaro Ohki, Nobutaka Kiyokawa, Yuya Saito, Shinsuke Hirabayashi, Kazuhiko Nakabayashi, Hitoshi Ichikawa, Yukihide Momozawa, Kohji Okamura, Ai Yoshimi, Hiroko Ogata-Kawata, Hiromi Sakamoto, Motohiro Kato, Keitaro Fukushima, Daisuke Hasegawa, Hiroko Fukushima, Masako Imai, Ryosuke Kajiwara, Takashi Koike, Isao Komori, Atsushi Matsui, Makiko Mori, Koichi Moriwaki, Yasushi Noguchi, Myoung-ja Park, Takahiro Ueda, Shohei Yamamoto, Koichi Matsuda, Teruhiko Yoshida, Kenji Matsumoto, Kenichiro Hata, Michiaki Kubo, Yoichi Matsubara, Hiroyuki Takahashi, Takashi Fukushima, Yasuhide Hayashi, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara, for the Tokyo Children’s Cancer Study Group (TCCSG)   +38 more
doaj   +1 more source

Raoultella ornithinolytica urinary tract infection in a pediatric patient with T-cell precursor acute lymphoblastic leukemia

Boletín Médico del Hospital Infantil de México, 2021
Background: Currently, Raoultella ornithinolytica is considered an emerging pathogen of community- and hospital-acquired infection, particularly in patients with immunodeficiencies, malignancies, anatomical abnormalities, or after invasive procedures ...
Ma. Camila Prada-Avella, Miguel A. Luengas-Monroy, Amaranto Suárez, Liliana M. Mora-Ramírez, Álvaro A. Faccini-Martínez   +4 more
doaj   +1 more source

A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

Blood, 2010
Abstract The serine/threonine Pim kinases are up-regulated in specific hematologic neoplasms, and play an important role in key signal transduction pathways, including those regulated by MYC, MYCN, FLT3-ITD, BCR-ABL, HOXA9, and EWS fusions.
Lin, Ying-Wei, Beharry, Zanna M, Hill, Elizabeth G, Song, Jin H, Wang, Wenxue, Xia, Zuping, Zhang, Zhenhua, Aplan, Peter D, Aster, Jon C, Smith, Charles D, Kraft, Andrew S   +10 more
openaire   +4 more sources

ABL oncogene amplification with p16^INK4a gene deletion in precursor T‐cell acute lymphoblastic leukemia/lymphoma: Report of the first case [PDF]

American Journal of Hematology, 2004
AbstractGene amplification is a relatively rare event in hematologic malignancies. The ABL gene on chromosome band 9q34 is a proto‐oncogene and is the well‐known translocation partner of the BCR gene on 22q11 giving rise to t(9;22)(q34;q11), which is the hallmark of chronic myeloid leukemia and is the most common chromosomal abnormality in adult acute ...
Hee-Jin, Kim, Hee-Yeon, Woo, Hong-Hoe, Koo, Eun-Young, Tak, Sun-Hee, Kim   +4 more
openaire   +2 more sources

Inotuzumab ozogamicin in clinical development for acute lymphoblastic leukemia and non-Hodgkin lymphoma

Biomarker Research, 2019
B cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) frequently express CD19, CD20 and CD22 on the cell surfaces. Immunotherapeutic agents including antibodies and chimeric antigen receptor T cells are widely studied in clinical ...
Amandeep Aujla, Ravijot Aujla, Delong Liu   +2 more
doaj   +1 more source

Phosphoproteomic Analysis Reveals a Different Proteomic Profile in Pediatric Patients With T-Cell Lymphoblastic Lymphoma or T-Cell Acute Lymphoblastic Leukemia

Frontiers in Oncology, 2022
T-cell lymphoblastic lymphoma (T-LBL) and lymphoblastic leukemia (T-ALL) arise from the transformation of precursor T-cells sharing common morphological and immunophenotypic features.
Giulia Veltri, Giulia Veltri, Federica Lovisa, Giuliana Cortese, Marta Pillon, Elisa Carraro, Simone Cesaro, Massimo Provenzi, Salvatore Buffardi, Samuela Francescato, Alessandra Biffi, Alessandra Biffi, Barbara Buldini, Barbara Buldini, Valentino Conter, Valentina Serafin, Valentina Serafin, Lara Mussolin, Lara Mussolin   +18 more
doaj   +1 more source

Additional file 1 of Haploidentical CD7 CAR T-cells induced remission in a patient with TP53 mutated relapsed and refractory early T-cell precursor lymphoblastic leukemia/lymphoma

, 2022
Additional file 1 : Supplementary Figure 1. Flow cytometry analysis on the anti-CD7 CAR T-cells. Supplementary Figure 2. Cytotoxicity analysis of the anti-CD7 CAR T-cells. Supplementary Figure 3. Timeline of treatments and responses. Supplementary Figure 4. T-cell fractions in the PB post CAR T-cells infusion. Supplementary Table 1.
Dai, Hai-ping, Cui, Wei, Cui, Qing-ya, Zhu, Wen-juan, Meng, Hui-min, Zhu, Min-qing, Zhu, Xia-ming, Yang, Lin, Wu, De-pei, Tang, Xiao-wen   +9 more
openaire   +1 more source

A Challenging Case of Gamma Delta T-Cell Lymphoma with Precursor T-Cells and Marked Eosinophilia: A Case Report

Case Reports in Oncology, 2020
Gamma-delta (γδ) T-cell lymphomas are very rare and aggressive neoplasms. We describe here a challenging case of γδ T-cell neoplasm composed of γδ mature T-cells and γδ precursor T-cells with marked eosinophilia that is inapplicable to the current 2016 ...
Samah Kohla, Feryal Ibrahim, Ilham Bilal, Einas Al Kuwari, Ahmad Al-Sabbagh   +4 more
doaj   +1 more source