Results 31 to 40 of about 50,528 (188)

Aberrant synaptophysin expression in classic Hodgkin lymphoma

Diagnostic Pathology, 2022
Background Synaptophysin is an immunohistochemical marker for neuroendocrine differentiation and is widely used in pathologic diagnosis. Its expression in malignant lymphoma has not yet been described.
Soyoung Im, Jeong-A. Kim, Gyeongsin Park, Uiju Cho   +3 more
doaj   +1 more source

Outcome of T‐cell acute lymphoblastic leukemia/lymphoma: Focus on near‐ETP phenotype and differential impact of nelarabine

American journal of hematology/oncology, 2021
Early T‐cell precursor acute lymphoblastic leukemia/lymphoma (ETP‐ALL/LBL) is characterized by a distinct immunophenotype (CD1a‐negative, CD8‐negative, CD5‐negative or weak‐positive
Kiyomi Morita, N. Jain, H. Kantarjian, Koichi Takahashi, Hong Fang, M. Konopleva, S. El Hussein, Feng Wang, N. Short, A. Maiti, K. Sasaki, G. Garcia-Manero, S. Konoplev, F. Ravandi, J. Khoury, E. Jabbour   +15 more
semanticscholar   +1 more source

Aberrant positivity for CD79a in erythroid lineage cells – a finding observed in a subset of re-staging bone marrow trephine biopsies after treatment

Haematologica, 2007
Aberrant expression of CD79a has been reported in neoplastic cells in peripheral T cell lymphoma, T-cell acute lymphoblastic leukemia and acute myeloid leukemia (especially those with t(8;21)).
Rashpal Singh Flora, Finella Brito-Babapulle, Kikkeri N. Naresh   +2 more
doaj   +1 more source

Nelarabine (NEL), Pegylated Asparginase (PEG) and Venetoclax (VEN) Incorporated to HCVAD Chemotherapy in the Frontline Treatment of Adult Patients with T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma (T-ALL/T-LBL)

Blood, 2023
Background: The incorporation of novel agents such as NEL and PEG to frontline therapy has been associated with improved outcomes in pediatric patients (pts) with T-ALL/LBL, but has not been extensively studied in the adult pts. BCL-2 upregulation has
J. Senapati, H. Kantarjian, E. Jabbour, R. Babakhanlou, T. Kadia, G. Borthakur, M. Konopleva, W. Wierda, J. Burger, G. Issa, A. Maiti, Hayley S. Balkin, M. Kelly, Rebecca E. Garris, A. Ferrajoli, G. Garcia-Manero, Yesid Alvarado Valero, P. Kebriaei, N. Short, N. Jain, F. Ravandi   +20 more
semanticscholar   +1 more source

Raoultella ornithinolytica urinary tract infection in a pediatric patient with T-cell precursor acute lymphoblastic leukemia

Boletín Médico del Hospital Infantil de México, 2021
Background: Currently, Raoultella ornithinolytica is considered an emerging pathogen of community- and hospital-acquired infection, particularly in patients with immunodeficiencies, malignancies, anatomical abnormalities, or after invasive procedures ...
Ma. Camila Prada-Avella, Miguel A. Luengas-Monroy, Amaranto Suárez, Liliana M. Mora-Ramírez, Álvaro A. Faccini-Martínez   +4 more
doaj   +1 more source

Primary and secondary anti-viral response captured by the dynamics and phenotype of individual T cell clones [PDF]

eLife 2020;9:e53704 (2020), 2019
The diverse repertoire of T-cell receptors (TCR) plays a key role in the adaptive immune response to infections. Previous studies show that secondary responses to the yellow fever vaccine - the model for acute infection in humans - are weaker than primary ones, but only quantitative measurements can describe the concentration changes and lineage fates ...
arxiv   +1 more source

Clinical and molecular characteristics of MEF2D fusion-positive B-cell precursor acute lymphoblastic leukemia in childhood, including a novel translocation resulting in MEF2D-HNRNPH1 gene fusion

Haematologica, 2019
Fusion genes involving MEF2D have recently been identified in precursor B-cell acute lymphoblastic leukemia, mutually exclusive of the common risk stratifying genetic abnormalities, although their true incidence and associated clinical characteristics ...
Kentaro Ohki, Nobutaka Kiyokawa, Yuya Saito, Shinsuke Hirabayashi, Kazuhiko Nakabayashi, Hitoshi Ichikawa, Yukihide Momozawa, Kohji Okamura, Ai Yoshimi, Hiroko Ogata-Kawata, Hiromi Sakamoto, Motohiro Kato, Keitaro Fukushima, Daisuke Hasegawa, Hiroko Fukushima, Masako Imai, Ryosuke Kajiwara, Takashi Koike, Isao Komori, Atsushi Matsui, Makiko Mori, Koichi Moriwaki, Yasushi Noguchi, Myoung-ja Park, Takahiro Ueda, Shohei Yamamoto, Koichi Matsuda, Teruhiko Yoshida, Kenji Matsumoto, Kenichiro Hata, Michiaki Kubo, Yoichi Matsubara, Hiroyuki Takahashi, Takashi Fukushima, Yasuhide Hayashi, Katsuyoshi Koh, Atsushi Manabe, Akira Ohara, for the Tokyo Children’s Cancer Study Group (TCCSG)   +38 more
doaj   +1 more source

Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]

npj Systems Biology and Applications, 10(1), 105 (2024), 2023
As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv   +1 more source

Inotuzumab ozogamicin in clinical development for acute lymphoblastic leukemia and non-Hodgkin lymphoma

Biomarker Research, 2019
B cell acute lymphoblastic leukemia (ALL) and non-Hodgkin lymphoma (NHL) frequently express CD19, CD20 and CD22 on the cell surfaces. Immunotherapeutic agents including antibodies and chimeric antigen receptor T cells are widely studied in clinical ...
Amandeep Aujla, Ravijot Aujla, Delong Liu   +2 more
doaj   +1 more source

A Challenging Case of Gamma Delta T-Cell Lymphoma with Precursor T-Cells and Marked Eosinophilia: A Case Report

Case Reports in Oncology, 2020
Gamma-delta (γδ) T-cell lymphomas are very rare and aggressive neoplasms. We describe here a challenging case of γδ T-cell neoplasm composed of γδ mature T-cells and γδ precursor T-cells with marked eosinophilia that is inapplicable to the current 2016 ...
Samah Kohla, Feryal Ibrahim, Ilham Bilal, Einas Al Kuwari, Ahmad Al-Sabbagh   +4 more
doaj   +1 more source