Results 51 to 60 of about 50,528 (188)

Genomic landscape of T-cell lymphoblastic lymphoma

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2022
Objective T-cell lymphoblastic lymphoma (T-LBL) is an aggressive neoplasm of precursor T cells, however, detailed genome-wide sequencing of large T-LBL cohorts has not been performed due to its rarity.
Zhaoming Li, Yue Song, Mingzhi Zhang, Yiming Wei, Hang Ruan   +4 more
semanticscholar   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

T-cell lymphoblastic lymphoma and leukemia: different diseases from a common premalignant progenitor?

Blood Advances, 2020
T-cell lymphoblastic lymphoma (T-LBL) and lymphoblastic leukemia (T-ALL) represent malignancies that arise from the transformation of immature precursor T cells.
E. Kroeze, J. Loeffen, V. M. Poort, J. Meijerink   +3 more
semanticscholar   +1 more source

Genomic and clinical characterization of early T-cell precursor lymphoblastic lymphoma.

Blood Advances, 2021
Early T-cell precursor phenotype acute lymphoblastic leukemia (ETP-ALL) is a subtype of T-ALL with a unique immunophenotype and genetic abnormalities distinct from conventional T-ALL.
Xinjie Xu, C. Paxton, R. Hayashi, K. Dunsmore, S. Winter, S. Hunger, N. Winick, W. Carroll, M. Loh, M. Devidas, T. Gross, C. Bollard, S. Perkins, R. Miles   +13 more
semanticscholar   +1 more source

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings [PDF]

arXiv, 2022
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated. For glioma brain tumors, various CAR T-cell targets include IL13Ra2, EGFRvIII, HER2, EphA2, GD2, B7-H3, and chlorotoxin.
arxiv  

DETECTION OF HEMATOPOIETIC NEOPLASMS IN CEREBROSPINAL FLUID BY IMMUNOPHENOTYPING: SINGLE-CENTER DATA ANALYSIS

Hematology, Transfusion and Cell Therapy, 2021
Introduction: Cerebrospinal fluid (CSF) infiltration can be identified at diagnosis and during the course of many hematopoietic malignancies, mainly acute leukemia and aggressive non-Hodgking lymphomas (NHL).
GF Bevilacqua, CM Bertolucci, AR Severino, RL Teotonio, M Penitenti, JE Conti-Spilari, MRV Ikoma-Colturato   +6 more
doaj  

CAR T Cells Beyond Cancer: Hope for Immunomodulatory Therapy of Infectious Diseases

Frontiers in Immunology, 2019
Infectious diseases are still a significant cause of morbidity and mortality worldwide. Despite the progress in drug development, the occurrence of microbial resistance is still a significant concern.
Michelle Seif, Hermann Einsele, Jürgen Löffler   +2 more
doaj   +1 more source

Flow Sorting, Whole Genome Amplification and Next-Generation Sequencing as Combined Tools to Study Heterogeneous Acute Lymphoblastic Leukemia

Diagnostics, 2023
Next-generation sequencing (NGS) methods have been introduced for immunoglobulin (IG)/T-cell receptor (TR) gene rearrangement analysis in acute lymphoblastic leukemia (ALL) and lymphoma (LBL).
Rabiah Fardoos, Claus Christensen, Nina Friesgaard Øbro, Ulrik Malthe Overgaard, Bodil Als-Nielsen, Hans Ole Madsen, Hanne Vibeke Marquart   +6 more
doaj   +1 more source

The potential role of environmentally associated DNA methylation in childhood acute lymphoblastic leukaemia subtypes

International Journal of Cancer, EarlyView.
What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville, Lisa J. Russell, Kay Padget, Akram Ghantous, Jessica Nordlund, Jill A. McKay   +5 more
wiley   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source