Results 61 to 70 of about 50,528 (188)

Statistical inference of the generation probability of T-cell receptors from sequence repertoires [PDF]

PNAS October 2, 2012 vol. 109 no. 40 16161-16166, 2012
Stochastic rearrangement of germline DNA by VDJ recombination is at the origin of immune system diversity. This process is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and deletions from, genes.
arxiv   +1 more source

High-mobility group box (TOX) antibody a useful tool for the identification of B and T cell subpopulations.

PLoS ONE, 2020
Thymocyte selection-associated high-mobility group box (TOX) is a DNA-binding factor that is able to regulate transcription by modifying local chromatin structure and modulating the formation of multi-protein complexes.
Lorena Maestre, Juan Fernando García-García, Scherezade Jiménez, Ana Isabel Reyes-García, Álvaro García-González, Santiago Montes-Moreno, Alberto J Arribas, Patricia González-García, Eduardo Caleiras, Alison H Banham, Miguel Ángel Piris, Giovanna Roncador   +11 more
doaj   +1 more source

Genomic signatures and prognosis of advanced stage Chinese pediatric T cell lymphoblastic lymphoma by whole exome sequencing

Frontiers in Pediatrics, 2023
ObjectiveTo investigate the genomic signatures and prognosis of advanced-stage T cell lymphoblastic lymphoma (T-LBL) and to examine the relationship between T-LBL and T cell acute lymphoblastic leukemia (T-ALL).Methods35 Chinese T-LBL children with stage
Qinglin Liu, Xiang Yu, Xiang Yu, Xiang Yu, Jinquan Wen, Nange Yin, Nange Yin, Nange Yin, Xin Liao, Xin Liao, Pinli Zou, Pinli Zou, Yuxia Guo, Yuxia Guo, Yuxia Guo, Lin Song, Lin Song, Jianwen Xiao, Jianwen Xiao, Jianwen Xiao   +19 more
doaj   +1 more source

A Systematic Review of Synthetic and Anticancer and Antimicrobial Activity of Quinazoline/Quinazolin‐4‐one Analogues

ChemistryOpen, EarlyView.
Quinazoline represents an important class of heterocycles with diverse medicinal and pharmacological significance. This review systematically examines scholarly efforts toward understanding different synthetic pathways emphasizing the role of metal and non‐metal catalysts including some miscellaneous reagents employed in the synthesis of quinazoline ...
Neha Manhas, Gobind Kumar, Sanjeev Dhawan, Talent Makhanya, Parvesh Singh   +4 more
wiley   +1 more source

Gum hypertrophy - an unusual presenting feature in a case of precursor T-cell acute lymphoblastic leukemia

Turkish Journal of Hematology, 2008
Acute lymphoblastic leukemia/lymphoma, the malignant transformation of T-cell or B-cell precursors, is the most common diagnosis in pediatric oncology. Precursor T-cell acute lymphoblastic leukemia/lymphoma commonly affects adolescents, and is associated
Lingappa Appaji, Rudramurthy Pradeep, Vishweshwariah Lakshmidevi, Davanam Satyanarayana Madhumati, Chennagiri Srinivasamurthy Premalata, Geetashree Mukherjee   +5 more
doaj  

Blinatumomab for the Treatment of Adult B-Cell Acute Lymphoblastic Leukemia: Toward a New Era of Targeted Immunotherapy

Biologics: Targets & Therapy, 2020
Miguel J Franquiz,1,2 Nicholas J Short2 1Baylor College of Medicine, Houston, TX, USA; 2Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USACorrespondence: Nicholas J ShortDepartment of Leukemia, The University of ...
Franquiz MJ, Short NJ
doaj  

Treatment outcomes for acute T-lymphoblastic leukemias/lymphomas: data from the ALL-2016 multicenter prospective randomized trial

Онкогематология, 2023
Background. The effectiveness of therapy for acute T-lymphoblastic leukemia (T-ALL) and T-lymphoblastic lymphoma (T-LBL) has significantly improved over the past decades, including through the implementation of hematopoietic stem cell transplantation ...
O. A. Aleshina, I. V. Galtseva, E. S. Kotova, G. I. Isinova, T. N. Obukhova, V. N. Dvirnik, A. B. Sudarikov, M. E. Grishunina, O. S. Samoilova, K. D. Kaplanov, V. A. Lapin, S. N. Bondarenko, E. S. Fokina, N. V. Minaeva, T. S. Konstantinova, Yu. V. Sveshnikova, E. E. Zinina, A. S. Antipova, O. Yu. Baranova, E. A. Borisenkova, Yu. O. Davydova, N. M. Kapranov, S. M. Kulikov, Yu. A. Chabaeva, V. V. Troitskaya, E. N. Parovichnikova   +25 more
doaj   +1 more source

Prediction of B/T Subtype and ETV6–RUNX1 Translocation in Pediatric Acute Lymphoblastic Leukemia by Deep Learning Analysis of Giemsa‐Stained Whole Slide Images of Bone Marrow Aspirates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Accurate determination of B/T‐cell lineage and the presence of the ETV6–RUNX1 translocation is critical for diagnosing acute lymphoblastic leukemia (ALL), as these factors influence treatment decisions and outcomes. However, these diagnostic processes often rely on advanced tools unavailable in low‐resource settings, creating a need
Arkadi Piven, Gil Shamai, Sarah Elitzur, Galit Pinto Berger, Yoav Binenbaum, Ron Kimmel, Ronit Elhasid   +6 more
wiley   +1 more source

Precursor T-Cell Lymphoblastic Lymphoma Presenting as Cardiac Tamponade in a 25-Year-Old Male: A Case Report and Review of Literature

World Journal of Oncology, 2014
Precursor T-cell lymphoblastic lymphoma (LBL) and T-cell acute lymphoblastic leukemia (ALL) are considered same disease with different clinical presentations.
Sakshi Kapur, M. Levin
semanticscholar   +1 more source

CD34-Negative B-Lymphoblastic Leukemia/Lymphoma Presenting as Cutenous Lesions at Infancy: A Case Report

The Journal of Bioscience and Medicine, 2022
Acute lymphoblastic leukemia/lymphoma is a highly aggressive neoplasm of precursor lymphoid (blast) cells. There are 2 main subtypes based on lymphoid lineage; B lymphoblastic leukemia/lymphoma (B-ALL/LBL) and T lymphoblastic leukemia/lymphoma (T-ALL/LBL)
T. Lotodo, F. Njuguna, S. Kiprono, G. Olbara, Nicholas Kigen   +4 more
semanticscholar   +1 more source