A treat‐to‐target approach for obesity management: A post hoc analysis of the SURMOUNT‐5 trial
Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3355-3366, April 2026.Abstract Introduction With new advancements in obesity medicine, clarity on goals and expectations for successful disease management is limited. This post hoc analysis assessed application of proposed treat‐to‐target (TtT) thresholds for obesity to the outcome measures of SURMOUNT‐5, which randomised participants with obesity to tirzepatide or ...
Carel W. le Roux +10 more
wiley +1 more source
Opposite kinetics of L-leucine and L-phenylalanine induced insulin release studies with the perfused rat pancreas [PDF]
, 1972 Landgraf, R. +3 more
core
Journal of Internal Medicine, Volume 299, Issue 4, Page 481-501, April 2026.Abstract Background and Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disease globally, but its prevalence and severity remain poorly characterized in the general population. Our aim was to estimate the prevalence of MASLD and the risk of advanced fibrosis in a large Swedish general population ...
Oumarou Nabi +10 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Here, Systemic Sonic Hedgehog (Shh) emerges as a sex‐specific metabolic signal and potential biomarker. Across two large cohorts, Shh rose selectively in females with type 2 diabetes, with a sharp pre‐diagnostic increase in about one‐quarter of cases, indicating value for early risk stratification.
Johannes Alfredsson +11 more
wiley +1 more source
Understanding barriers and facilitators of adherence to lifestyle changes in prediabetes: a qualitative study. [PDF]
Int J Qual Stud Health Well-beingCarvalho-Azevedo AS +7 more
europepmc +1 more source
Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome.
Canadian Journal of Diabetes, 2018 Z. Punthakee +2 more
semanticscholar +1 more source
Heartfelt intervention: A role for PVN oxytocin neurons in the prediabetic heart
The Journal of Physiology, EarlyView.
Grace K. Nielsen +2 more
wiley +1 more source
Advancing Precision Nutrition Through Multimodal Data and Artificial Intelligence
Advanced Science, Volume 13, Issue 17, 23 March 2026.Individual responses to food vary dramatically, challenging traditional dietary advice. This review explores how the unique genetic makeup, gut microbiome, and brain activity shape host metabolic health. We examine how artificial intelligence integrates these multimodal data to predict individualized dietary needs, moving beyond one‐size‐fits‐all ...
Yuanqing Fu +5 more
wiley +1 more source
Does menopause influence the association between atherogenic index of plasma and prediabetes? A cross-sectional study in middle-aged Chinese women. [PDF]
PLoS OneOuyang B +5 more
europepmc +1 more source
Resistance training and subcortical vascular cognitive impairment: A 12‐month randomized trial
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). METHODS We conducted a 12‐month randomized trial comparing PRT versus balance and tone exercises (BAT) on the ...
Teresa Liu‐Ambrose +13 more
wiley +1 more source