Results 81 to 90 of about 1,580,663 (249)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Changes in a Giant Iceberg Created from the Collapse of the Larsen C Ice Shelf, Antarctic Peninsula, Derived from Sentinel-1 and CryoSat-2 Data

Remote Sensing, 2019
The giant tabular iceberg A68 broke away from the Larsen C Ice Shelf, Antarctic Peninsula, in July 2017. The evolution of A68 would have been affected by both the Larsen C Ice Shelf, the surrounding sea ice, and the nearby shallow seafloor. In this study,
Hyangsun Han, Sungjae Lee, Jae-In Kim, Seung Hee Kim, Hyun-cheol Kim   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Porphyra Polysaccharides Alleviated High-Carbohydrate Diet-Induced Growth Retardation, Lipid Deposition, Impairment of Immune and Antioxidant Functions, and Intestinal Morphology in Rabbitfish (Siganus canaliculatus)

Aquaculture Nutrition
Porphyra polysaccharide (PPS), derived from marine red seaweeds of the Porphyra genus, has been reported to improve growth performance, lipid metabolism, and antioxidant capability in animals.
Ruixin Li, Wenkai Li, Jiaying Xie, Zhixiao Liu, Yi Xiao, Douglas R. Tocher, Cuiying Chen, Fan Lin, Xiaojuan Liu, Dizhi Xie, Yucong Hong, Shuqi Wang   +11 more
doaj   +1 more source

Impact of Cloud Microphysics Initialization Using Satellite and Radar Data on CMA-MESO Forecasts

Remote Sensing
High-resolution numerical weather prediction requires accurate cloud microphysical initial conditions to enhance forecasting capabilities for high-impact severe weather events such as convective storms.
Lijuan Zhu, Yuan Jiang, Jiandong Gong, Dan Wang   +3 more
doaj   +1 more source

A review of the seismotectonics of the Makran Subduction Zone as a baseline for Tsunami Hazard Assessments

Geoscience Letters, 2019
The Makran Accretionary Wedge (900 km across) is a consequence of northward subduction of the oceanic part of the Arabian Plate beneath the Lut and Afghan blocks in the northwestern Indian Ocean.
Mohammad Mokhtari, Ahmad Ala Amjadi, Leila Mahshadnia, Mandana Rafizadeh   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Review of Pre-processing Techniques for Meteorological Satellite Data Assimilation in Numerical Prediction

应用气象学报
Satellite data assimilation pre-processing plays a crucial role in bridging satellite data pre-processing and numerical weather prediction model assimilation.
Ma Gang, Huang Jing, Gong Xinya, Xi Shuang, Xue Lei, Li Juan, Zhang Peng, Gong Jiandong   +7 more
doaj   +1 more source