Results 101 to 110 of about 29,110,946 (332)

A Churn Prediction Model Using Random Forest: Analysis of Machine Learning Techniques for Churn Prediction and Factor Identification in Telecom Sector

IEEE Access, 2019
In the telecom sector, a huge volume of data is being generated on a daily basis due to a vast client base. Decision makers and business analysts emphasized that attaining new customers is costlier than retaining the existing ones.
I. Ullah, B. Raza, Ahmad Kamran Malik, Muhammad Imran, Saif ul Islam, S. Kim   +5 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Predictive Modeling

, 2023
Abstract This chapter progresses from explanatory to predictive models. Topics include cross-validation, model performance metrics, prediction intervals, bias–variance tradeoff, tree-based algorithms, and various types of models with utility in classification and forecasting applications.
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

In-depth mining of clinical data: the construction of clinical prediction model with R.

Annals of Translational Medicine, 2019
This article is the series of methodology of clinical prediction model construction (total 16 sections of this methodology series). The first section mainly introduces the concept, current application status, construction methods and processes ...
Zhi-rui Zhou, Wei-Wei Wang, Yan Li, Kairui Jin, Xuan Wang, Zi-Wei Wang, Yishan Chen, Shaoqian Wang, Jing Hu, Huina Zhang, Po Huang, Guozhen Zhao, Xing-Xing Chen, Bo Li, Tian-Song Zhang   +14 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Estimation of Final Size of COVID-19 Epidemic in Balochistan Province, Pakistan

The International Journal of Frontier Sciences
COVID-19 is a new disease that is spreading very fast in Pakistan. Cases have been reported from all of the provinces including Balochistan. The first two confirmed cases in Pakistan had travel history by road from Iran to Balochistan, hence SIR model ...
Muhammad Arif, Aftab Kakar, Ehsan Larik
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Neural–genetic–environmental evidence for a disease factor in mental and physical health multimorbidity

Nature Communications
Increasing evidence reveals the presence of multimorbidity across physical and mental disorders. A general disease factor (d factor) has been recently identified to capture the shared liability across these conditions, yet its biological basis remains ...
Jin Chen, Yuning Zhang, Shu Liu, Miguel Garcia-Argibay, Tianye Jia, Jujiao Kang, Wei Li, Marco Solmi, Hongyi Sun, Wenqi Liu, Congying Chu, Samuele Cortese, Jiaojian Wang   +12 more
doaj   +1 more source