Results 201 to 210 of about 29,110,946 (332)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

A Clinical Data-Based Nomogram Prediction Model for ARDS in Patients With Acute Pancreatitis. [PDF]

Int J Gen Med
Liu X, Gu Q, He H, Zhang Y.
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Development of a risk prediction model for left ventricular thrombosis in STEMI patients. [PDF]

Front Cardiovasc Med
Wang J, Ma P, Xu Q, Hai L, Zhang S.
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Mamba6mA: a Mamba-based DNA N6-methyladenine site prediction model. [PDF]

Bioinformatics
Zhao Q, Zhang Z, Chen T, Mao Q, Shi H, Chen J, Zhao Z, Fan X.   +7 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model.

JAMA Netw Open
Wong A, Currey D, Schwinne M, Park-Egan B, Meyer S, Gutting A, Cao J, Khan S, Dantes R, Pan T, Buchman T, Singh K, Bhavani SV, Lyons PG, Sjoding MW, Tarabichi Y.   +15 more
europepmc   +1 more source

Construction and Evaluation of a Prediction Model for Neonatal Hyperbilirubinemia. [PDF]

Int J Gen Med
Xu S, Guo X, Li C, Chen J, Zhang C.
europepmc   +1 more source

Prediction model

The metabolic alterations from the four anticipated subtypes of metastases in the FOLFOX treatment that relate best to organoid survival will be selected D13 as the scan protocol Threshold levels will be based on cluster analyses incorporating in vivo baselines D43This report will give a description of the prediction model and a guideline on how the ...
openaire   +1 more source