Results 221 to 230 of about 2,534,918 (292)

Network biology to artificial intelligence: building the next generation of predictive drug discovery. [PDF]

Front Immunol
Selvarajoo K.
europepmc   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Predicting Psychological Flourishing Among Psychologists: Integrating Self-Compassion, Traditional Regression, and Machine Learning Approaches. [PDF]

Healthcare (Basel)
Alhalawany RM, AlNufaie RF, Khatatbeh YM.   +2 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Distinct predictive factors for acute severe ulcerative colitis in East Asian and Western populations. [PDF]

Inflamm Bowel Dis
Kim ES, Kim DH, Kim SJ, Park SH, Lee HS, Kim SK, Kim HS, Lee J, Kim KO, Jang BI, Lee YJ, Song EM, Kim DS, Lin CC, Mak JWY, Liu J, Cao Q, Wei SC, Lin WC, Hsu WH, Sagami S, Kobayashi T, Fernandes RG, Gilmore R, An YK, Begun J, Rice K, Ruddick-Collins L, Vasudevan A, Zhang J, Brownson A, Ngoi B, Lynch K, Haifer C, Bracken LML, Swe E, Wright E, Clark N, Schildkraut T, Mahy G, Moore G, Gazelakis K, Garg M, Schultz M, Australia New Zealand IBD Consortium (ANZIBDC) and the Asian Organization for Crohn’s and Colitis (AOCC).   +44 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Comparative Analysis of Kinematic and Identified MIMO Models in Model Predictive Control for Mobile Robot Trajectory Tracking. [PDF]

Sensors (Basel)
Guffanti D, Pavon W, Zapata A.
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source