Results 91 to 100 of about 10,121,442 (237)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Enhanced Model Predictive Control Using State Variable Feedback for Steady-State Error Cancellation

Sensors
The rapid dynamic responses of predictive control algorithms are widely acknowledged. However, achieving accurate steady-state reference tracking hinges not just on a precise mathematical model of the system but also on its parameters.
Marcos Andreu, Jaime Rohten, José Espinoza, José Silva, Esteban Pulido, Lesyani Leon   +5 more
doaj   +1 more source

Estimation and control using sampling-based Bayesian reinforcement learning

IET Cyber-Physical Systems, 2019
Real-world autonomous systems operate under uncertainty about both their pose and dynamics. Autonomous control systems must simultaneously perform estimation and control tasks to maintain robustness to changing dynamics or modelling errors.
Patrick Slade, Zachary N. Sunberg, Zachary N. Sunberg, Mykel J. Kochenderfer   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Extreme learning-based non-linear model predictive controller for an autonomous underwater vehicle: simulation and experimental results

IET Cyber-systems and Robotics, 2019
In this study, an extreme learning-based non-linear model predictive controller (NMPC) is proposed for path following planning of an autonomous underwater vehicle (AUV) using horizontal way-points. The proposed controller comprises a kinematic controller
Biranchi Narayan Rath, Bidyadhar Subudhi
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Voltage space vector‘s computation for current control in three phase converters

Revista Facultad de Ingeniería Universidad de Antioquia, 2012
This work presents two current loop techniques, for three phase voltage source converters (VSC) used as controlled rectifiers (CR) operating at unity power factor.
Alberto Berzoy, Julio Viola, José Restrepo   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Model predictive control architecture for rotorcraft inverse simulation [PDF]

, 2013
A novel inverse simulation scheme is proposed for applications to rotorcraft dynamic models. The algorithm adopts an architecture that closely resembles that of a model predictive control scheme, where the controlled plant is represented by a high-order ...
AVANZINI, Giulio, Torasso A., Avanzini, G., Thomson, D., Torasso, A., Thomson D   +5 more
core   +1 more source