Results 101 to 110 of about 472,321 (294)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The impact of different body surface area prediction equations on ventricular dilatation prevalence in youth soccer players

Frontiers in Cardiovascular Medicine
BackgroundThe normalization of echocardiographic variables for body surface area (BSA) enables to obtain relative indexes of ventricular size that are useful for diagnosis and monitoring of non-ischaemic cardiomyopathies.
Marco Alessandro Minetto, Elisabetta Toso, Federico Della Vecchia, Andrea Ferraris, Massimo Magistrali, Gianluca Alunni, Chiara Busso, Angelo Pietrobelli, Angelo Pietrobelli, John A. Shepherd, Steven B. Heymsfield   +10 more
doaj   +1 more source

Does Money Matter? An Empirical Investigation [PDF]

This paper uses a simultaneous-equations model of the new consensus macroeconomic model to examine whether the inclusion of the money stock in the aggregate demand function improves the statistical fit of the model.
Barry Huston, Farrokh Nourzad, James M. McGibany   +2 more
core  

A predictive equation for drug-induced lupus

Medical Hypotheses, 2003
Objective was to quantify the chemical mechanisms of drug-induced lupus (DIL), and to make the data of different authors comparable between them. I have used seven assumptions as a starting point, based on empirical evidence; then an equation is drawn, describing the relationship between the quantity of the drug taken by the patient(s) and the ...
University of Florida, Gainesville, FL, USA ( host institution ), Adhami, E   +1 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

New Predictive Equations for Resting Energy Expenditure in Normal to Overweight and Obese Population

International Journal of Endocrinology, 2019
Background and Aims. The unique demographic and dietary characteristics of modern Arabic population require development of a new predictive equation for the estimation of resting energy expenditure (REE). This study presented new equations characteristic
Ali M. Almajwal, Mahmoud M. A. Abulmeaty
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

CRITICAL CONSIDERATIONS ON THE SINGLE VERTICAL JUMP TEST AS AN INDICATOR OF LOWER-LIMB POWER: PRELIMINARY FINDINGS

Studia Universitatis Babeş-Bolyai: Educatio Artis Gymnasticae
Introduction: The vertical jump test (VJT) is widely used to estimate lower-limb power through predictive equations, but the theoretical validity of these models remains uncertain.
Vlad Adrian GEANTĂ, Pierre Joseph DE HILLERIN   +1 more
doaj   +1 more source

A near-wall turbulence model and its application to fully developed turbulent channel and pipe flows [PDF]

A near wall turbulence model and its incorporation into a multiple-time-scale turbulence model are presented. In the method, the conservation of mass, momentum, and the turbulent kinetic energy equations are integrated up to the wall; and the energy ...
Kim, S.-W.
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source