Results 111 to 120 of about 4,798,414 (293)

Downregulation of ferroptosis-related Genes can regulate the invasion and migration of osteosarcoma cells

Scientific Reports
Osteosarcoma (OS) is a prevalent form of bone cancer among younger people, particularly children and adolescents. Ferroptosis is a non-apoptotic cell death identified by increased levels of iron-dependent lipid peroxidation.
Rui Ding, Le Liao, Jiahui Chen, Jian Zhang, Shenghao Cai, Xinxin Miao, Tao Li, Jiangminghao Zhao, Qi Chen, Xigao Cheng, Jianjian Deng   +10 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The current predictive assays and score systems, the factors included in score systems and the methods used; the target prediction and final results.

, 2017
The current predictive assays and score systems, the factors included in score systems and the methods used; the target prediction and final results.
Naeem Chaudhri (3612446), Tamara Leclercq (3612452), Damith Ranasinghe (3612455), Fred Brown (3612458), Haneen Banjar (3612464), Trent Kroger (3612449), David Adelson (3612461), Deborah White (3523247), Timothy Hughes (56285)   +8 more
core   +1 more source

Evaluation of non-canonical p53 functions in DNA replication and recombination for variant classification

Cell Death and Disease
Pathogenic germline TP53 variants predispose to diverse Li-Fraumeni syndrome (LFS) phenotypes and a broad cancer spectrum, whereby carriers of hypomorphic variants cluster in a cohort with attenuated disease onset and an overrepresentation of breast ...
Rebecca Jansche, Benedikt Heitmeir, Ulrike Faust, Helmut Pospiech, Christian Sutter, Christian Albig, Finja Hennig, Wolfgang Janni, Rita Schmutzler, Jan Hauke, Andreas C. Joerger, Lisa Wiesmüller   +11 more
doaj   +1 more source

LncRNA NR2F1-AS1 serves as a diagnostic biomarker for diabetic peripheral neuropathy and promotes disease progression by regulating miR-150-5p

Molecular and Cellular Probes
Background: Diabetic peripheral neuropathy (DPN) is a common intractable complication of type 2 diabetes mellitus (T2DM), lacking specific diagnostic markers and therapeutic targets.
Yazhi Zhao, Shiling Rong, Xiaoya Ren, Gengliang Zhang, Xiaoxiao Li   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Patient-derived cell lines unveil COL1A2 as a predictor of docetaxel resistance in breast cancer

Frontiers in Oncology
IntroductionBreast cancer is the most common malignant tumor among women worldwide and a major cause of cancer-related mortality. Chemoresistance presents a significant challenge in breast cancer therapy and is a primary driver of tumor recurrence and ...
Yuwei Gao, Rong Wang, Xiaowei Dou, Xiaowei Dou, Song Chen, Wenhao Chen, Jinting Liu, Suo Zhu, Jianjun Huang, Jianjun Huang, Qingjun Gao, Qingjun Gao   +11 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source