Results 121 to 130 of about 4,798,414 (293)

Identification and validation of DPP4 in predicting the prognosis of clear cell RCC

Discover Oncology
Dipeptidyl peptidase-4 (DPP4) has been implicated in tumor progression, yet its role in clear cell renal cell carcinoma (KIRC) remains poorly understood. This study aimed to comprehensively investigate the expression profile, prognostic significance, and
Min Luo, Peifeng Li
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Tumor-suppressive role of miR-216b impacts cell cycle regulation in high-grade glioma

Acta Neuropathologica Communications
High-grade gliomas (HGGs) are the most aggressive adult brain tumors, with a dismal median survival of approximately 15 months, highlighting the need for novel therapeutic strategies.
Alexandra Lang, Sabine Buerger, Leah Mager, Lea Erjavc, Barbara Kiesel, Sibylle Madlener, Carola Nadine Jaunecker, Linda Pacher, Finn Christopher Robert, Leonie Krausgruber, Andrezza Nascimento, Sarah Machreich, Gerda Ricken, Lisa Gabler-Pamer, Anna Laemmerer, Sabine Spiegl-Kreinecker, Matthias Hackl, Marianne Pultar, Johannes Reisecker, Katharina Bruckner, Barbara Neudert, Leonhard Muellauer, Dominik Kirchhofer, Mario Mischkulnig, Anna Sophie Berghoff, Adelheid Woehrer, Daniel Senfter, Karl Roessler, Thomas Roetzer-Pejrimovsky, Walter Berger, Johannes Andreas Hainfellner, Romana Hoeftberger, Georg Widhalm, Friedrich Erhart, Daniela Lötsch-Gojo   +34 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Strategies for GH functional annotation: toward harmonized and predictive CAZymology.

The functional annotation and biochemical characterization of glycoside hydrolases (GHs) for polysaccharides and oligosaccharides deconstruction are a major challenge.
Hughes, A E, Griffin, N G, Munoz-Munoz, J, Berlemont, R, Erdody, D S   +4 more
core   +1 more source

PO087 | BEYOND POSITIVITY: THE HIERARCHICAL ROLE OF IMMUNOASSAYS IN HEPARIN INDUCED THROMBOCYTOPENIA

Bleeding, Thrombosis and Vascular Biology
Background and aims. Heparin induced thrombocytopenia (HIT) is an immune mediated disorder induced by the exposure to heparin with subsequent production of antibodies against heparin-platelet factor 4 (H-PF4) complexes. The diagnosis of HIT is based on a
Giovanni Murante
doaj  

Development of an Ex Vivo Functional Assay for Prediction of Irradiation Related Toxicity in Healthy Oral Mucosa Tissue

International Journal of Molecular Sciences
Background: Radiotherapy in the head-and-neck area is one of the main curative treatment options. However, this comes at the cost of varying levels of normal tissue toxicity, affecting up to 80% of patients. Mucositis can cause pain, weight loss and treatment delay leading to worse outcomes and decreased quality of life.
Katrin S. Pachler, Iris Lauwers, Nicole S. Verkaik, Marta Rovituso, Ernst van der Wal, Hetty Mast, Brend P. Jonker, Aniel Sewnaik, Jose A. Hardillo, Stijn Keereweer, Dominiek Monserez, Bernd Kremer, Sjors Koppes, Thierry P. P. van den Bosch, Gerda M. Verduijn, Steven Petit, Brita S. Sørensen, Dik C. van Gent, Marta E. Capala   +18 more
openaire   +2 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Unraveling the complex genetic landscape of OTOF-related hearing loss: a deep dive into cryptic variants and haplotype phasing

Molecular Medicine
Background Pathogenic variants in OTOF are a major cause of auditory synaptopathy. However, challenges remain in interpreting OTOF variants, including difficulties in confirming haplotype phasing using traditional short-read sequencing (SRS) due to the ...
Pei-Hsuan Lin, Cheng-Yu Tsai, Yu-Ting Chiang, Chang-Han Ho, Yue-Sheng Lu, Jacob Shu-Jui Hsu, Yen-Fu Cheng, Shih-Feng Tsai, Chuan-Jen Hsu, Pei-Lung Chen, Chen-Chi Wu   +10 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source