Results 131 to 140 of about 4,798,414 (293)

Failure of prediction of liver function test abnormalities with the urine urobilinogen and urine bilirubin assays.

Archives of pathology & laboratory medicine, 1989
A prospective observational study of 229 cases was conducted in a busy ambulatory care setting to evaluate the sensitivity, specificity, predictive values, and accuracy of spot urine urobilinogen and urine bilirubin assays as screening tests for serum liver function test (LFT) abnormalities. Both urine tests exhibited remarkably similar characteristics
L, Binder, D, Smith, T, Kupka, B, Nelson, B, Glass, M, Wainscott, J, Haynes   +6 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Engineering Human 3D Cardiac Tissues for Predictive Functional Drug Screening

Pharmaceutics
Background/Objectives: Cardiotoxicity remains a leading cause of drug withdrawal. Conventional preclinical models, such as two-dimensional (2D) cell cultures and animal studies, often fail to accurately predict human cardiac responses.
Ester Sapir Baruch, Daniel Rosner, Elisabeth Riska, Moran Yadid, Assaf Shapira, Tal Dvir   +5 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Biophysical Sensing Tools in Drug Discovery: Integrating Kinetics, Thermodynamics, Cellular Target Engagement and Structure

Sensors
Biophysical sensing technologies have become central to modern drug discovery because they enable direct, quantitative characterization of ligand–target interactions.
Esra Balıkçı, Caner Akıl
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

In vitro characterization of three GPR39 agonists and Zn²⁺ in functional and binding assays.

, 2018
In vitro characterization of three GPR39 agonists and Zn2+ in functional and binding assays.
Daniel Hovdal (840615), Richard J. Isaacs (840621), Stefan Geschwindner (840623), Niklas Larsson (840609), Andrew Turnbull (343913), Charlotte Wennberg-Huldt (840614), Anders Johansson (18368), Takuma Tsuchida (840611), Daniel Brown (840622), Claire Priest (840625), Hajime Fukuda (840616), Anna Marley (840613), Johan Brengdahl (840620), Sara Lundqvist (840619), Ola Fjellström (687218), Lambertus Benthem (840624), Takahiro Oguma (840612), Yukimi Yoneyama (840617), Shin-ichiro Yasuda (840610), Kazuyo Sasaki (840618)   +19 more
core   +1 more source

A novel long non-coding RNA SLNCR1 promotes proliferation, migration, and invasion of melanoma via transcriptionally regulating SOX5

Cell Death Discovery
Steroid receptor RNA activator (SRA)-like non-coding RNA (SLNCR1) has been implicated in various tumorigenic processes, but the precise regulatory role in melanoma progression remains uncertain.
Lele Cong, Qing Zhao, Hongyan Sun, Zilong Zhou, Yue Hu, Chunyi Li, Miao Hao, Xianling Cong   +7 more
doaj   +1 more source

Multi-omics characterization of RNA modification enzymes identifies NAT10 as a functionally validated prognostic biomarker in hepatocellular carcinoma

Frontiers in Immunology
BackgroundRNA modification enzymes (RMEs) are key post-transcriptional regulators that impact RNA stability, translation, and splicing. Dysregulation of RMEs is closely associated with tumor initiation and progression.
Qianqian Zhan, Qianqian Zhan, Qianqian Zhan, Huihui Sun, Huihui Sun, Xiangting Wang, Xiangting Wang, Xiaolin Liang, Xiaolin Liang   +8 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source