Results 251 to 260 of about 4,798,414 (293)

Can Immune Function Assay Predict Infection or Recovery?

Transplantation Proceedings, 2012
Recently, the ImmuKnow assay (Cylex Inc., Columbia, Md) has been reported to be a global immune monitoring tool for organ transplants recipients. We assessed whether immunKnow ATP values predicted infectious syndromes.We prospectively enrolled 71 kidney transplant patients between September 2008 and May 2011.
H H, Moon, T-S, Kim, Y-N, Roh, S, Lee, S, Song, M, Shin, J M, Kim, C, Hyuck, D, Kwon, S-J, Kim, J-W, Joh, S-K, Lee   +11 more
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Functional assays are mandatory for a correct prediction of immunotoxic properties of compounds in vitro

Food and Chemical Toxicology, 2009
An increasing aim in safety assessment of chemicals and drugs is to reduce, refine and replace animal testing, especially in the context of the new system for the registration, evaluation and authorisation of chemicals (REACH). Regarding immunosuppression, most methods are based on mitogen stimulation assays.
L-M, Koeper, H-W, Vohr
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Utility of in vivo zebrafish cardiac assay to predict the functional impact of KCNQ1 variants

European Heart Journal, 2022
Abstract Background Genetic testing for inherited arrhythmias and discriminating pathogenic from benign variants are integral for the gene-based medicine. However, the high throughput in vivo functional analysis for the rare variants of the KCNQ1 potassium channel is scarce.
S Cui, K Hayashi, K Usuda, S Usui, K Sakata, M Kawashiri, T Kusayama, T Tsuda, N Fujino, T Kato, M Takamura   +10 more
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Mutation prediction by PolyPhen or functional assay, a detailed comparison of CYP27B1 missense mutations

Endocrine, 2011
Vitamin D-dependent rickets type 1 (VDDR-I) is caused by mutation in CYP27B1. The glycine residue at codon 102 is not conserved between human (G(102)) and rodent (S(102)). G102E mutation results in 80% reduction in its enzymatic activity but PolyPhen predicts benign change.
Minjing, Zou, Essa Y, Baitei, Ali S, Alzahrani, Ranjit S, Parhar, Futwan A, Al-Mohanna, Brian F, Meyer, Yufei, Shi   +6 more
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Accuracy of urine urobilinogen and bilirubin assays in predicting liver function test abnormalities

Annals of Emergency Medicine, 1987
Components of the dipstick urinalysis (urine urobilinogen and urine bilirubin) are often used by emergency physicians to screen for the need to obtain liver function tests in many clinical situations. A prospective observational study was conducted to evaluate the sensitivity, specificity, and predictive properties of spot urine bilirubin and ...
T, Kupka, L S, Binder, D A, Smith, B K, Nelson, M P, Wainscott, B A, Glass   +5 more
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An immune function assay predicts post-transplant recurrence in patients with hepatocellular carcinoma

Journal of Cancer Research and Clinical Oncology, 2011
An immune function assay has been proposed as a new strategy to monitor immunosuppression after organ transplantation. However, there are limited data regarding its role in liver transplant recipients with hepatocellular carcinoma (HCC). In this study, we sought to determine the utility of this functional assay in assessing the risk of infection ...
Jian-Wen, Cheng, Ying-Hong, Shi, Jia, Fan, Xiao-Wu, Huang, Shuang-Jian, Qiu, Yong-Sheng, Xiao, Zheng, Wang, Zhi, Dai, Zhao-You, Tang, Jian, Zhou   +9 more
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Abstract 1782: Functional potency assay predicts CAR-T effectiveness in tumor microenvironment

Cancer Research, 2023
Abstract Chimeric antigen receptor (CAR) T cell therapy holds great promise for the treatment of various cancers, including solid tumors. However, attempts to model the behavior and effectiveness of CAR-T cell therapies for blood cancers and solid tumors have been challenging due to the unique tumor microenvironments in which these ...
Yelena Bronevetsky, Evan Massi, Candy Garcia, Ningchun Liu, Yewei Xing, Natalie Czeryba, Scott Wise, James Lim   +7 more
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Prediction strategy for screening functional Haloarchaea strains with qPCR assays

Journal of Microbiological Methods
As an extremophile resource, functional Haloarchaea strains are extremely time-consuming to screen. Here, taking the screening of low-salt-tolerant strains as an example, based on the qPCR assays that shortened time by 4-7 times and achieved 100 % accuracy, a universal strategy for rapid and accurate screening of functional Haloarchaea strains was ...
Xinyu, Hu, Wenxiang, Sun, Meng, Zhang, Wenjun, Guo, Shujing, Yang, Lin, Zhu, Xiang, Xiao, Xiangru, Xu, Wei, Wei   +8 more
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MEndR: An In Vitro Functional Assay to Predict In Vivo Muscle Stem Cell‐Mediated Repair

Advanced Functional Materials, 2021
AbstractFunctional assessment of stem cell‐mediated endogenous repair relies on animal studies. Here an in vitro assay is described that recapitulates important early steps of the in vivo skeletal muscle endogenous repair (MEndR) process. The assay is integrated with a custom semi‐automated image analysis pipeline to enable high‐content data analysis ...
Sadegh Davoudi, Bin Xu, Erik Jacques, Jose L. Cadavid, Matthew McFee, Chih‐Ying Chin, Amir Meysami, Majid Ebrahimi, Mohsen A. Bakooshli, Kayee Tung, Henry Ahn, Howard J. Ginsberg, Alison P. McGuigan, Penney M. Gilbert   +13 more
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The value of semen analysis and sperm function assays in predicting pregnancy among infertile couples

Fertility and Sterility, 1990
Over a 2-year period, 227 couples were evaluated by an extended assessment of the male partner's ejaculate. This extended assessment comprised sperm penetration of denuded hamster oocytes, ability of sperm to penetrate synthetic mucus, and the adenosine triphosphate (ATP) content of whole semen.
R B, Gwatkin, J A, Collins, J F, Jarrell, J, Kohut, R A, Milner   +4 more
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