Results 261 to 270 of about 4,798,414 (293)

Predictive Performance Study of Two Digoxin Assays in Subjects With Various Degrees of Renal Function

Therapeutic Drug Monitoring, 2000
This prospective study was conducted to compare the predictive performance of fluorescence polarization immunoassay (FPIA, Abbott TDx Digoxin II) and radioimmunoassay (RIA, Kallestad Labs) with combined low-pressure liquid chromatography/RIA (LPLC/RIA) digoxin assay in measuring 15-17 serum digoxin concentrations (SDC) obtained after a single 10 microg/
S A, Spinler, A S, Al-Jazairi, J W, Cheng, S, Kapoor, S, Kobrin, L, Shaw   +5 more
openaire   +2 more sources

Predicting in vitro assays related to liver function using probabilistic machine learning

Toxicology
While machine learning has gained traction in toxicological assessments, the limited data availability requires the quantification of uncertainty of in silico predictions for reliable decision-making. This study addresses the challenge of predicting the outcome of in vitro assays associated with liver function by systematically comparing various ...
Flavio M. Morelli, Marian Raschke, Natalia Jungmann, Michaela Bairlein, Marina García de Lomana   +4 more
openaire   +2 more sources

Novel paraoxonase (PON1) nonsense and missense mutations predicted by functional genomic assay of PON1 status

Pharmacogenetics, 2003
Paraoxonase (PON1) has been termed an environmental response enzyme for its function in the detoxification of organophosphate pesticides, nerve agents and pharmaceuticals such as glucocorticoids and statins, as well as its cardioprotective role in breaking down oxidized LDL.
Gail P, Jarvik, Rachel, Jampsa, Rebecca J, Richter, Chris S, Carlson, Mark J, Rieder, Deborah A, Nickerson, Clement E, Furlong   +6 more
openaire   +2 more sources

A Functional Assay for Peripheral Blood T Cells to Predict Acute Graft-Versus-Host Disease.

Blood, 2009
Abstract Abstract 4497 Patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) are at high risk to develop acute graft-versus-host disease (aGVHD) which is caused by alloreactive donor T cells. Early diagnosis of aGVHD remains difficult: there are no efficient methods to identify patients at risk of ...
Carina A Baeuerlein, Christian Brede, Simone S Riedel, Ana-Laura Jordán-Garrote, Carolin Kiesel, Miriam Ritz, Stephan Schulz, Marina Grether, Georg F Beilhack, Tor B Stuge, Robert S Negrin, Hermann Einsele, Andreas Beilhack   +12 more
openaire   +1 more source

Peripheral blood T-cell functional assay as a predictive biomarker of immune-therapy of metastatic melanoma.

Journal of Clinical Oncology, 2018
e21593Background: Activating effector T cell by inhibitory checkpoint blockade improves survival in metastatic melanoma (MM).
Harsh V Parmar, Nitya Chakraborty, Upendra P. Hegde   +2 more
openaire   +1 more source

[Significance of functional assay of multidrug resistance for prediction of chemotherapy outcomes in acute leukemia].

Ai zheng = Aizheng = Chinese journal of cancer, 2004
It is well known that the multidrug resistance (MDR) efflux protein, P-glycoprotein (P-gp), plays an important role in mediating MDR in acute leukemia. Several studies have shown that the expression level of P-gp and its encoding gene MDR1 mRNA level are associated with the response of chemotherapy.
Xu, Ye, Huo, Tan, Ying, Feng, Hang, Su, Yi-Yan, Lai, Ying, Pang   +5 more
openaire   +1 more source

Predictive Value of Immune Cell Functional Assay for Non-Cytomegalovirus Infection in Lung Transplant Recipients: A Multicenter Prospective Observational Study

Archivos De Bronconeumologia, 2021
Pedro Marcos, Cristina Berastegui, Amparo Solé   +2 more
exaly   +2 more sources

DO FUNCTIONAL ASSAYS HAVE PREDICTIVE VALUE IN SIBLING BONE MARROW TRANSPLANTATION?

Transplantation, 2000
Brookes, P, Lechler, R I
openaire   +3 more sources

Improving valvulopathy prediction by qualifying 5-HT2B functional assay technologies

Journal of Pharmacological and Toxicological Methods, 2020
Annie Otto-Bruc, Alexandre Baron, Frederique Redoules, Benoit Fouchaq, Steve Davies   +4 more
openaire   +1 more source

SP-0521 Functional assays to predict individual patient responses to radiotherapy

Radiotherapy and Oncology, 2023
openaire   +1 more source