Results 21 to 30 of about 4,798,414 (293)

Sperm function assays and their predictive value for fertilization outcome in IVF therapy: a meta-analysis [PDF]

Human Reproduction Update, 2000
The prevalence of male infertility and the availability of new, highly successful therapeutic options make the testing of sperm functional competence mandatory. An objective, outcome-based examination of the validity of the currently available assays was performed based upon the results obtained from 2906 subjects evaluated in 34 prospectively designed,
Oehninger SC, Franken DR, Sayed E, Barroso G, Kolm P   +4 more
openaire   +2 more sources

Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis. [PDF]

PLoS Genetics, 2007
A novel candidate metastasis modifier, ribosomal RNA processing 1 homolog B (Rrp1b), was identified through two independent approaches. First, yeast two-hybrid, immunoprecipitation, and functional assays demonstrated a physical and functional interaction
Nigel P S Crawford, Xiaolan Qian, Argyrios Ziogas, Alex G Papageorge, Brenda J Boersma, Renard C Walker, Luanne Lukes, William L Rowe, Jinghui Zhang, Stefan Ambs, Douglas R Lowy, Hoda Anton-Culver, Kent W Hunter   +12 more
doaj   +1 more source

A personalized functional assay that predicts clinical outcomes in embryo transfer

North American Proceedings in Gynecology and Obstetrics - Supplemental
Objective: We aimed to develop a personalized assay based on patient-derived endometrial organoids to predict frozen embryo transfer (FET) outcomes after in vitro fertilization (IVF). Design: We collected endometrial biopsies from over 100 patients preparing for FET.
Elissa Tjahjono, Madeline Kaye, George Grunert, Scott Novich, Yael Katz, Aryeh Warmflash   +5 more
openaire   +2 more sources

OPD (Online Plasmodium Diagnosis): An ALA-PpIX based functional assay to predict active malaria

Photodiagnosis and Photodynamic Therapy, 2021
Malaria kills one child every 30 seconds reaching up to 3000 children a day. The mosquito borne malarial parasite invades the blood stream and hijacks red blood cells (RBCs). One of the medical successes of the 20th century was development of malaria diagnostic tests. However, poor specificity and sensitivity along with the inability of these assays to
Shoaib, Ashraf, Jeffrey, Agyapong, Petra, Rohrbach, Tayyaba, Hasan   +3 more
openaire   +2 more sources

Early changes in rpS6 phosphorylation and BH3 profiling predict response to chemotherapy in AML cells. [PDF]

PLoS ONE, 2018
Blasts from different patients with acute myeloid leukemia (AML) vary in the agent(s) to which they are most responsive. With a myriad of novel agents to evaluate, there is a lack of predictive biomarkers to precisely assign targeted therapies to ...
Martin Grundy, Thomas Jones, Liban Elmi, Michael Hall, Adam Graham, Nigel Russell, Monica Pallis   +6 more
doaj   +1 more source

Development of an Anoikis-Related Gene Signature for Lung Squamous Cell Carcinomato Predict Prognosis, Immune Landscape, and Immunotherapy Response

Journal of Immunology Research, 2023
Background. Anoikis, a form of programed cell death, plays a pivotal role in the invasion and metastasis of various tumors, including lung squamous cell carcinoma (LUSC).
Jian Liu, Hui Zheng, Li Wei
doaj   +1 more source

Perinatal derivatives: How to best validate their immunomodulatory functions

Frontiers in Bioengineering and Biotechnology, 2022
Perinatal tissues, mainly the placenta and umbilical cord, contain a variety of different somatic stem and progenitor cell types, including those of the hematopoietic system, multipotent mesenchymal stromal cells (MSCs), epithelial cells and amnion ...
Andrea Papait, Andrea Papait, Antonietta Rosa Silini, Maria Gazouli, Ricardo Malvicini, Ricardo Malvicini, Maurizio Muraca, Lorraine O’Driscoll, Lorraine O’Driscoll, Lorraine O’Driscoll, Natalia Pacienza, Wei Seong Toh, Gustavo Yannarelli, Peter Ponsaerts, Ornella Parolini, Ornella Parolini, Günther Eissner, Michela Pozzobon, Sai Kiang Lim, Bernd Giebel   +19 more
doaj   +1 more source

AlphaMissense is better correlated with functional assays of missense impact than earlier prediction algorithms

, 2023
Abstract Missense variants that alter a single amino acid in the encoded protein contribute to many human disorders but pose a substantial challenge in interpretation. Though these variants can be reliably identified through sequencing, distinguishing the clinically significant ones remains difficult, such that ...
Alicia Ljungdahl, Sayeh Kohani, Nicholas F. Page, Eloise S. Wells, Emilie M. Wigdor, Shan Dong, Stephan J. Sanders   +6 more
openaire   +2 more sources

Theory and practice of predictive assays in radiation therapy

, 1997
Purpose: An overview of the field of predictive assays is presented. It has been written with the many clinicians and scientists in mind who would like to become better acquainted with the general scope, principles and themes in the field.Results ...
Crompton, N.E.A. (author), Larsson, B. (author), Luetolf, U.M. (author), Ozsahin, M. (author), Schweizer, P. (author), Crompton NE, Larsson B, Ozsahin M, Schweizer P, Luetolf UM   +9 more
core   +3 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source