Results 41 to 50 of about 4,798,414 (293)

Comparative analysis of three functional predictive assays in lymphocytes of patients with breast and gynaecological cancer treated by radiotherapy

, 2012
Purpose: There is a need to develop predictive tests that would allow identifying cancer patients with a high risk of developing side effects to radiotherapy. We compared the predictive value of three functional assays: the G(0) aberration assay, the G(2)
Kuszewski, Tomasz, Lankoff, Anna, Florek, Agnieszka, Lisowska, Halina, Padjas, Anna, Wojcik, Andrzej,, Gozdz, Stanislaw, Kedzierawski, Piotr, Kukolowicz, Pawel   +8 more
core   +1 more source

The PENDOR study: establishment of a panel of patient-derived tumor organoids from endometrial cancer to assess efficacy of PARP inhibitors

BMC Cancer
Background Combination of chemotherapy and immunotherapy is the current standard of care for advanced endometrial cancer. However, survival outcome remains poor, highlighting the urgent need for new treatments and reliable tools to identify patients who ...
Gwenn Le Gall, François Cherifi, Jordane Divoux, Romane Florent, François Christy, Alexandra Leconte, Chankannira San, Amélie Devillers, Guillaume Desmartin, Lucie Lecouflet, Bénédicte Clarisse, Samantha Ballesta, Lucie Thorel, Brice Dubois, Valentin Harter, Nathalie Rousseau, Léopold Gaichies, Sandrine Martin-Françoise, Jean-François Le Brun, Enora Dolivet, Roman Rouzier, Corinne Jeanne, Cécile Blanc-Fournier, Martin Figeac, Raphaël Leman, Laurent Castera, Laurent Poulain, Louis-Bastien Weiswald, Florence Joly   +28 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessing concordance among human, in silico predictions and functional assays on genetic variant classification

Bioinformatics, 2019
Abstract Motivation A variety of in silico tools have been developed and frequently used to aid high-throughput rapid variant classification, but their performances vary, and their ability to classify variants of uncertain significance were not systemically assessed previously due to lack of ...
Jiaqi Luo, Tianliangwen Zhou, Xiaobin You, Yi Zi, Xiaoting Li, Yangming Wu, Zhaoji Lan, Qihuan Zhi, Dandan Yi, Lei Xu, Ang Li, Zaixuan Zhong, Mei Zhu, Gang Sun, Tao Zhu, Jianmei Rao, Luhua Lin, Jianfeng Sang, Yujian Shi   +18 more
openaire   +5 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Sensitivity, specificity, positive and negative predictive value, and accuracy of ELISA assays in diagnosing canine sera.

, 2019
Sensitivity, specificity, positive and negative predictive value, and accuracy of ELISA assays in diagnosing canine sera.
João Luis Reis Cunha (6282017), Guilherme Rafael Gomide Pinheiro (6282023), Williane Fernanda Siqueira (6282026), Daniella Castanheira Bartholomeu (144315), Ricardo Toshio Fujiwara (144314), Lilian Lacerda Bueno (199085), Lucas Dhom-Lemos (6282011), Tiago Antônio Oliveira Mendes (6282020), Leandro Freitas Teles (6282029), Silvio Fernando Guimarães-Carvalho (6282032), Francisco Pereira Lobo (144303), Mariana Santos Cardoso (834562), Agostinho Gonçalves Viana (6282014)   +12 more
core   +1 more source

A microfluidic platform for functional assays on tumour biopsy-derived spheroids for precision medicine [PDF]

, 2020
Precision medicine aims to determine the ideal treatment for each cancer patient through the use of genomic and molecular diagnostics, as well as functional chemo-sensitivity screening assays.
Mulholland, Theresa Elisabeth
core   +2 more sources

Comprehensive evaluation of diverse massively parallel reporter assays to functionally characterize human enhancers genome-wide

Genome Biology
Background Massively parallel reporter assays (MPRAs) and self-transcribing active regulatory region sequencing (STARR-seq) have revolutionized enhancer characterization by enabling high-throughput functional assessment of regulatory sequences.
Junke Zhang, Alden King-Yung Leung, Yutong Zhu, Li Yao, Avery Willis, Xiuqi Pan, Abdullah Ozer, Zhou Zhou, Keith Siklenka, Alejandro Barrera, Jin Liang, Nathaniel D. Tippens, Timothy E. Reddy, John T. Lis, Haiyuan Yu   +14 more
doaj   +1 more source

Meta-analysis of massive parallel reporter assays enables functional regulatory elements prediction [PDF]

, 2017
ABSTRACT Deciphering the potential of non-coding loci to influence gene regulation has been the subject of intense research, with important implications in understanding genetic underpinnings of human diseases. Massively parallel reporter assays (MPRAs) can measure regulatory activity of thousands of DNA-sequences and their variants in ...
Kreimer, Anat, Yan, Zhongxia, Ahituv, Nadav, Yosef, Nir   +3 more
openaire   +1 more source