Predicting Angiogenesis by Endothelial Progenitor Cells Relying on In-Vitro Function Assays and VEGFR-2 Expression Levels [PDF]
Biomolecules, 2019 Clinical trials have demonstrated the safety and efficacy of autologous endothelial progenitor cell (EPC) therapy in various diseases. Since EPCs’ functions are influenced by genetic, systemic and environmental factors, the therapeutic potential of each individual EPCs is unknown and may affect treatment outcome.
Sabbah, Nadin +5 more
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Optimized conditions for radioligand binding and functional assays.
, 2019 Optimized conditions for radioligand binding and functional assays.
Daniel Womer (6807767) +4 more
core +1 more source
Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3,4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays [PDF]
, 2000 1-Keto-1,2,3,4-tetrahydrophenanthrene (THP-1) was reported by Cook et al in 1933 as the first synthetic estrogen. Estrogenic activity was assessed by the induction of vaginal cornification in ovariectomised rats.
Sumpter, JP +5 more
core +1 more source
Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens
Vaccines, 2019 The preferred product characteristics (for chemistry, control, and manufacture), in addition to safety and efficacy, are quintessential requirements for any successful therapeutic.
Cristina Poveda +3 more
doaj +1 more source
Meta‐analysis of massively parallel reporter assays enables prediction of regulatory function across cell types [PDF]
Human Mutation, 2019 Deciphering the potential of noncoding loci to influence gene regulation has been the subject of intense research, with important implications in understanding genetic underpinnings of human diseases. Massively parallel reporter assays (MPRAs) can measure regulatory activity of thousands of DNA sequences and their variants in a single experiment.
Anat Kreimer +3 more
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Functional assays in marine biotoxin detection
, 2005 The contamination of seafood by algal toxins regularly affects animals living in several areas of the world, and the number of toxic phycotoxins which are being characterized is steadily increasing.
ROSSINI, Gian Paolo
core +1 more source
Predictive Coding or Evidence Accumulation? False Inference and Neuronal Fluctuations [PDF]
, 2010 Perceptual decisions can be made when sensory input affords an inference about what generated that input. Here, we report findings from two independent perceptual experiments conducted during functional magnetic resonance imaging (fMRI) with a sparse ...
Andreas Kleinschmidt +11 more
core +2 more sources
, 2021 International audienceWithin the past few years, poly (ADP-ribose) polymerase inhibitors (PARPi) have been added to the standard of care for cancer patients, mainly for those exhibiting specific genomic alterations in the homologous recombination (HR ...
Poulain, Laurent +5 more
core +1 more source