Results 71 to 80 of about 4,798,414 (293)

Targeting PERP promotes anti-tumor immunity in HNSCC by regulating tumor immune microenvironment and metabolic homeostasis

Molecular Cancer
Background PERP may have the potential to function as an oncogene. However, the precise function, prognostic value, and predictive significance remain shrouded in ambiguity.
Xueying Wang, Yuxi Tian, Xiaohong Wu, Yewen Zhu, Huihong Chen, Zeyao Wang, Zihan Liu, Jiaqi Tan, Zhaoyu Pan, Jiaoyan Cao, Zhenjiang Li, Xin Zhang, Zhongjie Shi, Juncheng Wang, Tong Liu   +14 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Predictive Ability of the M30, M65, and M65ED Assays by Fibrosis Stage.

, 2015
Cutoff values were determined using receiver operating characteristic (ROC) curves.Predictive Ability of the M30, M65, and M65ED Assays by Fibrosis Stage.
Takeji Umemura (272474), Soichiro Shibata (496452), Michiharu Komatsu (496454), Yuki Ichikawa (760692), Akihiro Matsumoto (496455), Tomohiro Sekiguchi (760690), Takefumi Kimura (496453), Eiji Tanaka (111967), Naoyuki Fujimori (760691), Satoru Joshita (496451), Masao Ota (157102)   +10 more
core   +1 more source

The OVAREX study: Establishment of ex vivo ovarian cancer models to validate innovative therapies and to identify predictive biomarkers

BMC Cancer
Background Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development of chemoresistance. Despite the emergence of PARP inhibitors, which have revolutionized the therapeutic management of some of these ovarian ...
Lucie Thorel, Jordane Divoux, Justine Lequesne, Guillaume Babin, Pierre-Marie Morice, Romane Florent, Guillaume Desmartin, Lucie Lecouflet, Chloé Marde Alagama, Alexandra Leconte, Bénédicte Clarisse, Mélanie Briand, Roman Rouzier, Léopold Gaichies, Sandrine Martin-Françoise, Jean-François Le Brun, Christophe Denoyelle, Nicolas Vigneron, Corinne Jeanne, Cécile Blanc-Fournier, Raphaël Leman, Dominique Vaur, Martin Figeac, Matthieu Meryet-Figuiere, Florence Joly, Louis-Bastien Weiswald, Laurent Poulain, Enora Dolivet   +27 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Results of sensitivity, specificity, positive and negative predictive value, and accuracy of the ELISA assays assessed using human sera.

, 2019
Results of sensitivity, specificity, positive and negative predictive value, and accuracy of the ELISA assays assessed using human sera.
João Luis Reis Cunha (6282017), Guilherme Rafael Gomide Pinheiro (6282023), Williane Fernanda Siqueira (6282026), Daniella Castanheira Bartholomeu (144315), Ricardo Toshio Fujiwara (144314), Lilian Lacerda Bueno (199085), Lucas Dhom-Lemos (6282011), Tiago Antônio Oliveira Mendes (6282020), Leandro Freitas Teles (6282029), Silvio Fernando Guimarães-Carvalho (6282032), Francisco Pereira Lobo (144303), Mariana Santos Cardoso (834562), Agostinho Gonçalves Viana (6282014)   +12 more
core   +1 more source

Malignant epithelial cell marker–driven risk signature enables precise stratification in esophageal cancer

Frontiers in Immunology
BackgroundEsophageal squamous cell carcinoma (ESCC) is a highly heterogeneous malignancy. Traditional clinical staging systems have limited value in prognostic evaluation and treatment guidance, often failing to capture the profound impact of ...
Hao Zhang, Hao Zhang, Shizhao Cheng, Shizhao Cheng, Yijun Xu, Yijun Xu   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

PREDICTIVE FUNCTIONAL CONTROLLER – SIMPLE PREDICTIVE CONTROLLER APPLICATION

, 2008
Článek pojednává o regulaci reálného zařízení jednoduchým a výpočetně nenáročným prediktivním regulátorem PFC (Predictive Functional Controller). Reálnou soustavu v našem případě představuje laboratorní model Hydraulickopneumatická soustava.
Mareš, Jan, Honc, Daniel
core   +1 more source