Results 81 to 90 of about 4,798,414 (293)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Model Predictive Traction and Steering Control of Planetary Rovers [PDF]

, 2013
Results of the ESA project RobMPC (Robust Model Predictive Control for Space Constraint Systems) could successfully demonstrate that model predictive control (MPC) is definitively applicable for space systems with high dynamics like wheeled vehicles ...
Krenn, R., Bemporad, Alberto, Krenn, Rainer, Gibbesch, A., Gibbesch, Andreas, Bemporad, A, Binet, Giovanni, Bemporad, A., Binet, G.   +8 more
core  

Unraveling the role of histone acetylation in sepsis biomarker discovery

Frontiers in Molecular Biosciences
IntroductionSepsis is a life-threatening condition caused by a dysregulated immune response to infection. Despite advances in clinical care, effective biomarkers for early diagnosis and prognosis remain lacking.
Feng Cheng, Juxin Deng, Zhaoyang Du, Lei Li, Zhaolei Qiu, Min Zhu, Hongchang Zhao, Hongchang Zhao, Zhenjie Wang, Zhenjie Wang   +9 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Predictive pole-placement control with linear models [PDF]

, 2002
The predictive pole-placement control method introduced in this paper embeds the classical pole-placement state feedback design into a quadratic optimisation-based model-predictive formulation. This provides an alternative to model-predictive controllers
Ronco, E., Gawthrop, P.J.
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

FOXM1-associated melanoma stratification: integrated multi-omics and experimental validation reveal prognostic significance and therapeutic potential

BMC Cancer
Background Cutaneous melanoma is a highly aggressive malignancy characterized by marked biological heterogeneity and variable clinical outcomes. Reliable biomarkers for prognostic stratification and biological characterization remain limited.
Zhichen Li, Zhenpeng Zhu, Ruixue Zhao, Luying Wang, Ran Huo   +4 more
doaj   +1 more source

Functional Antibody-Dependent Enhancement as an Immune Assessment Platform: Development, Standardization, and Translational Interpretation in Flavivirus Research

Pathogens
Functional antibody-dependent enhancement (ADE) represents a fundamental and context-dependent characteristic of antiviral antibody responses, reflecting the dual capacity of antibodies to mediate both the neutralization and Fc receptor-dependent ...
Meng Ling Moi
doaj   +1 more source