Results 61 to 70 of about 4,798,414 (293)

MiR-340-5p regulates PD-L1 and predicts pembrolizumab response in extranodal NK/T-cell lymphoma

Scientific Reports
Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive, chemoresistant non-Hodgkin lymphoma subtype with poor patient outcomes linked to elevated PD-L1 expression. This study investigates miRNA-mediated regulation of PD-L1, focusing on miR-340-5p and miR-
Kyung Ju Ryu, Haein Ji, Bon Park, Sang Eun Yoon, Junhun Cho, Won Seog Kim, Hyeon Ho Kim, Seok Jin Kim   +7 more
doaj   +1 more source

Predictive value of platelet function assays in traumatic brain injury patients on antiplatelet therapy

Journal of Trauma and Acute Care Surgery
INTRODUCTION Traumatic brain injury (TBI) patients on antiplatelet therapy face higher mortality because of impaired platelet function, which may be treated by platelet transfusion. The value of testing platelet function in this cohort remains controversial. We aimed to evaluate the relationship between platelet function assays
Nijmeh Alsaadi, Reem Younes, Jack R. Killinger, Lara Hoteit, Ava M. Puccio, Peyton McIntyre, Olivia Raymond, Amanda Filicky, Thomas Hahner, Allison G. Agnone, Laura E. Vincent, Amudan Srinivasan, Mohammadreza Zarisfi, Devin M. Dishong, Abiha Abdullah, Aishwarrya Arivudainambi, Ronit Kar, Emily P. Mihalko, Patricia Loughran, Stephen R. Wisniewski, James F. Luther, Philip C. Spinella, David Okonkwo, Francis X. Guyette, Jason L. Sperry, Susan M. Shea, Matthew D. Neal   +26 more
openaire   +2 more sources

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients [PDF]

Clinical Cancer Research, 2018
Abstract Purpose: Homologous recombination deficiency (HRD) correlates with platinum sensitivity in patients with ovarian cancer, which clinically is the most useful predictor of sensitivity to PARPi. To date, there are no reliable diagnostic tools to anticipate response to platinum-based chemotherapy, thus we aimed to develop an ex vivo
Tumiati, Manuela, Hietanen, Sakari, Hynninen, Johanna, Pietilä, Elina, Färkkilä, Anniina, Kaipio, Katja, Roering, Pia, Huhtinen, Kaisa, Alkodsi, Amjad, Li, Yilin, Lehtonen, Rainer, Erkan, Erdogan Pekcan, Tuominen, Minna M., Lehti, Kaisa, Hautaniemi, Sampsa K., Vähärautio, Anna, Grénman, Seija, Carpén, Olli, Kauppi, Liisa   +18 more
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Functional Assays for Individual Radiosensitivity A Critical Review

, 2017
International audienceA complete understanding of the mechanisms of the response to radiation would help in a better evaluation of the radiation-induced risks.
Mélanie L. Ferlazzo, Nicolas Foray, Ferlazzo, M.L., Foray, N., Bourguignon, M., Michel Bourguignon   +5 more
core   +1 more source

The Prognostic Significance of TRs in Hepatocellular Carcinoma: Insights from TCGA and GEO Databases

Biomarker Insights
Background: Reduced expression of thyroid hormone receptors (TRs) has been observed in various human malignancies, though its predictive value in hepatocellular carcinoma (HCC) remains uncertain.
Hao Zhou, Weijie Wang, Ruopeng Liang, Rongtao Zhu, Jiahui Cao, Chenguang Sun, Yuling Sun   +6 more
doaj   +1 more source

Motion based ex vivo (MOTEX) culture of breast tumor slices sustains microenvironment composition

Neoplasia: An International Journal for Oncology Research
Personalized medicine for breast cancer (BrC) requires predictive biomarkers to select the optimal therapeutic option for each individual patient. Personalization of chemotherapy or immunotherapy responses is particularly challenging, as molecular ...
Zofia M. Komar, Mieke Bavelaar, Ellen Kageler, Nicole S. Verkaik, Mandy M. van Rosmalen, Carolien H.M. van Deurzen, Michael A. den Bakker, Roland Kanaar, Adriaan B Houtsmuller, Thierry P.P. van den Bosch, Agnes Jager, Dik C. van Gent   +11 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Predictive factors of functional improvement^*.

, 2018
Predictive factors of functional improvement*.
Mitja Jevnikar (5434952), Xavier Jaïs (5220773), Francis Couturaud (821892), Sacha Mussot (647274), Cécile Tromeur (821891), Elie Fadel (471021), Jason Weatherald (5220770), Olivier Sitbon (777335), David Montani (467016), Florence Parent (5434946), Marc Humbert (23466), Dominique Fabre (5434949), Laurent Savale (777333), Gérald Simonneau (4722351), Philippe Dartevelle (471020), Olaf Mercier (471015)   +15 more
core   +1 more source

Sensitizing and protective substances in radiation therapy and predictive assays

, 2002
In an investigation by the Swedish Cancer Society, an expert group described the present status, critical issues and future aspects and potentials for each of nine major areas of radiation therapy research.
Carlsson, J, Kjellén, Elisabeth,, Zackrisson, B, Glimelius, B, Littbrand, B, Lund University., Turesson, Ingemar,   +6 more
core   +2 more sources